Bortezomib CAS 179324-69-7 Purity ≥99.0% (HPLC) API Factory High Purity
Supply Bortezomib Related Intermediates neHigh Purity
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Bortezomib CAS 179324-69-7
| Chemical Name | Bortezomib |
| Mashoko anoreva zvakafanana | Velcade, MG-341, PS-341 |
| Nhamba yeCAS | 179324-69-7 |
| Nhamba yeCAT | RF-API65 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram |
| Molecular Formula | C19H25BN4O4 |
| Molecular Weight | 384.24 |
| Melting Point | 122.0~124.0℃ |
| Density | 1.214 |
| Refractive Index | 1.564 |
| Solubility | Soluble muChloroform, DMSO, Ethanol uye Methanol |
| Kugadzikana | Hygroscopic uye Moisture Sensitive |
| Shipping Condition | Yakatumirwa Pasi peAmbient Temperature |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | White kana Off-White Powder |
| Kuchena / Analysis Method | ≥99.0% (HPLC) |
| Kurasika paKuomesa | ≤0.50% |
| Residue paIgnition | ≤0.20% |
| Optical Rotation | -41.0° ~ -46.0° |
| Simbi inorema | ≤20ppm |
| Acidity | 4.0~7.0 |
| Isomer | ≤0.50% |
| Kusachena Kumwechete | ≤0.50% |
| Zvose Zvisina Kuchena | ≤1.0% |
| Residual Solvents | |
| Methanol | ≤0.30% |
| Dichloromethane | ≤0.05% |
| Hexane | ≤0.02% |
| Ethyl Acetate | ≤0.50% |
| Test Standard | Enterprise Standard |
| Usage | API |
Package: Bhodhoro, Aluminium foil bag, Cardboard Drum, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri uye mutengesi weBortezomib (CAS: 179324-69-7) nemhando yepamusoro, API.
Bortezomib, inotengeswa pasi pezita rechiratidzo Velcade pakati pevamwe, mushonga unorwisa gomarara unoshandiswa kurapa akawanda myeloma uye mantle cell lymphoma.Bortezomib yakabvumirwa kushandiswa kwezvokurapa muUnited States mu2003 uye muEuropean Union mu2004. Iri paWorld Health Organization's List of Essential Medicines.Bortezomib ndiyo yekutanga proteasome inhibitor kubvumidzwa b iyo US FDA kune akawanda myeloma, kenza yeropa.A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle inowanikwa munucleus uye cytosol yemasero ese eukaryotic.Bortezomib inosarudza uye yakasimba 26S proteasome inhibitor, iyo inonzi boronic acid dipeptide derivative.Human pancreatic cancer cell studies inoratidza Bortezomib inhibit the PKR-like endoplasmic reticulum (ER) kinase uye kuwedzera ER kushushikana, zvichiita kuti apoptosis.
