Carvedilol CAS 72956-09-03 Kuchena > 99.0% (HPLC)

Tsanangudzo Pfupi

Kemikari Zita: Carvedilol

CAS: 72956-09-03

Kuchena:> 99.0% (HPLC)

Kuonekwa: White Crystalline Powder

Bata: Dr. Alvin Huang

Nharembozha/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Tumira email kwatiri

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Tsanangudzo:

Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri weCarvedilol (CAS: 72956-09-03) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Carvedilol,Please contact: alvin@ruifuchem.com

Related Intermediates:

Inoenderana Pakati peCarvedilol

N-(2-(2-Methoxyphenoxy)ethyl)benzylamine Hydrochloride	CAS: 3246-03-5
2-(2-Methoxyphenoxy) ethylamine Hydrochloride Hydrate	CAS 64464-07-9
2-(2-Methoxyphenoxy)ethylamine	CAS 1836-62-0
4-(2,3-Epoxypropoxy)carbazole	CAS 51997-51-4
4-Hydroxycarbazole	CAS 52602-39-8
1,3-Cyclohexanedione	CAS 504-02-9
Carvedilol	CAS 72956-09-03
Carvedilol Phosphate Hemihydrate	CAS 610309-89-2

Chemical Properties:

Chemical Name	Carvedilol
Mashoko anoreva zvakafanana	1-(9H-Carbazol-4-yloxy) -3-[[2-(2-Methoxyphenoxy)ethyl]amino]-2-Propanol;Artist;Cadilan;Carca;Cardivas;Carloc;Carvas;Carvedilol;Carvediol;Coreg;DQ 2466;Dilatrend;Dimitone;Eucardic;Korvasan;Kredex;Querto;Talliton;BM-14190
Stock Status	MuStock, GMP Commerce
Nhamba yeCAS	72956-09-3
Molecular Formula	C24H26N2O4
Molecular Weight	406.48 g/mol
Melting Point	115.0 kusvika 119.0 ℃
Density	1.250±0.06 g/cm3
Solubility mumvura	Insoluble muMvura
Solubility	Soluble muMethanol.Zvishoma Soluble muEthanol, Ether
Storage Temp.	Nzvimbo Inotonhorera & Yakaoma (2~8℃)
COA & MSDS	Available
Brand	Ruifu Chemical

Zvinotsanangurwa:

Items	Kuongorora Maitiro	Results
Chitarisiko	White Crystalline Powder	Zvinoenderana
Kurasika paKuomesa	≤0.50% (105℃ kwe3 h)	0.25%
Residue paIgnition	≤0.10%	0.07%
Related Substances
Zvose Zvisina Kuchena	≤0.50%	Zvinoenderana
Kusachena A	≤0.20%	Zvinoenderana
Kusachena C	≤0.02%	Zvinoenderana
Chero Kumwe Kusachena Kwemunhu	≤0.10%	Zvinoenderana
Masimbi anorema (Pb)	≤10ppm	<10ppm
Kuchena / Analysis Method	>99.0% (HPLC)	99.72%
Infrared Spectrum	Inopindirana neChimiro	Zvinoenderana
Mhedziso	Chigadzirwa chacho chakaedzwa uye chinoenderana nezvinodiwa

Pakeji/Kuchengeta/Shipping:

Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumudziyo wakavharwa zvakasimba.Chengetedza munzvimbo inotonhorera, yakaoma (2 ~ 8 ℃) uye ine mhepo yakanaka yekuchengetera kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.

Zvakanakira:

Yakakwana Capacity: Inokwana zvivakwa uye matekiniki

Professional Service: Imwe inomira kutenga sevhisi

OEM Package: Tsika pasuru uye label iripo

Fast Delivery: Kana iri mukati me stock, mazuva matatu ekutumira anovimbiswa

Yakagadzika Supply: Chengetedza zvine musoro stock

Tsigiro yehunyanzvi: Tekinoroji mhinduro iripo

Tsika Synthesis Service: Kubva pamagiramu kusvika makirogiramu

Hunhu Hwepamusoro: Yakagadzira yakakwana yemhando yekusimbisa system

FAQ:

Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.

Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.

Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.

HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.

Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.

Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.

MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.

Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.

Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.

Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.

Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.

Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.

72956-09-3 - Mashoko Ekuchengetedza:

Hazard Codes N,Xn
Njodzi Statements 51/53-36/37/38-20/21/22
Mashoko ekuchengetedza 61-36-26
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS UA8670000
HazardClass IRRITANT
PackingGroup III
Dhata Yezvinhu Zvinokuvadza 72956-09-3
Toxicity LD50 yemuromo mumbwa:> 1gm/kg

72956-09-3 -Application:

Carvedilol (CAS: 72956-09-03) inonzi vasodilating beta-blocker inobatsira pakurapa hypertension uye angina pectoris.Mukuwedzera pakuderedza kuderera kweropa, carvedilol inoderedza zvachose vascular resistance pasina reflex tachycardia inowanzoitika nevasodilators.Inonzi inobvumirwa zvakanaka nerenal sparing effects.

Carvedilol yakatanga kubudiswa muBelgium muna 1985. Ichi chigadzirwa chinogona kuvhara alpha uye beta receptors, pasina basa remukati, muhuwandu hwemafashoni ane calcium antagonism.Iyo ine simba rakasimba rekuvharira beta receptors, iyo inogona kuwedzera tsinga dzeropa, kuderedza peripheral kuramba uye kuderera kweropa, uye haina mhedzisiro yekubuda kwemoyo uye kurova kwemoyo.Clinical inogona kushandiswa kwekutanga hypertension uye angina pectoris.

72956-09-3 - USP 35 Standard:

DEFINITION

Carvedilol ine NLT 98.0% uye NMT 102.0% yeC24H26N2O4, yakaverengerwa pane yakaomeswa.

KUZIVA

• A. Infrared Absorption <197K>

• B. Nguva yekuchengeta yenhongonya huru yeSample solution inoenderana neiyo yeStandard solution, sezvakawanikwa muAssay.

ASSAY

• Maitiro

Buffer: 2.72 g/L ye monobasic potassium phosphate.Rongedza ne dilute phosphoric acid kusvika pH ye2.0.

Nharembozha chikamu: Acetonitrile uye Buffer (31:69)

Sistimu yakakodzera mhinduro: 0.05 mg/mL imwe neimwe yeUSP Carvedilol RS uye USP Carvedilol Inoenderana Compound A RS muMobile phase.

Mhinduro yakajairwa: 0.04 mg/mL yeUSP Carvedilol RS muMobile phase

Sample solution: 0.04 mg/mL yeCarvedilol muMobile phase

Chromatographic system

(Ona Chromatography <621>, System Suitability.)

Modhi: LC

Detector: UV 240 nm

Column: 4.6-mm × 15-cm;5-µm kurongedza L7

Column tembiricha: 55 ℃

Kuyerera: 1 mL / min

Nguva yekumhanya: 60 min

Jekiseni saizi: 10 µL

Kukodzera kwehurongwa

Sample: System kukodzera mhinduro

Kukodzera zvinodiwa

Resolution: NLT 4.0 pakati pecarvedilol uye carvedilol inoenderana nekomboni A

Tailing factor: NMT 1.5 ye carvedilol peak

Kutsauswa kwechiyereko: NMT 2%

Analysis

Samples: Yakajairwa mhinduro uye Sample mhinduro

Verenga chikamu che carvedilol (C24H26N2O4) muchikamu chemuenzaniso wakatorwa:

Mhedzisiro = (rU/rS) × (CS/CU) × 100

rU=	peak mhinduro ye carvedilol kubva kuSample solution
rS=	peak mhinduro ye carvedilol kubva kune Standard solution
CS=	kuwanda kwe carvedilol muiyo Standard solution (mg/mL)
CU=	kusangana kweCarvedilol muSample solution (mg/mL)

Maitiro ekugamuchira: 98.0% -102.0% pane yakaomeswa hwaro

KUSIRIRA

• Zvakasara paKubatidza <281>: NMT 0.1% kubva pa1 g

• Heavy Metals, Method II <231>: NMT 10 ppm

• Organic Impurities, Procedure 1: [Cherechedza-Pamusana petsvina iripo, ita kungave Organic Impurities, Procedure 1 kana Organic Impurities, Procedure 2. Organic Impurities, Procedure 2 inokurudzirwa kana carvedilol inoenderana necompound F inenge isina kuchena.]

Buffer uye Nharembozha chikamu: Gadzirira sekurairwa muAssay.

Kukodzera kweSystem mhinduro: 0.05 mg/mL imwe neimwe yeUSP Carvedilol RS uye USP Carvedilol Inoenderana Compound C RS muMobile phase

Sarudzo yakajairwa: 1 µg/mL imwe neimwe yeUSP Carvedilol RS, USP Carvedilol Inoenderana Necompound A RS, USP Carvedilol Inoenderana Mushonga B RS, USP Carvedilol Inoenderana Musanganiswa D RS, uye USP Carvedilol Inoenderana Compound E RS, uye 0.2 µg/mL ye USPG/mL Related Compound C RS muMobile phase

Sample solution: 1 mg/mL yeCarvedilol muMobile phase

Chromatographic system

(Ona Chromatography <621>, System Suitability.)

Modhi: LC

Detector: Dual wavelength, UV 220 uye 240 nm.Shandisa 220 nm yekuverenga carvedilol inoenderana nemubatanidzwa E, uye shandisa 240 nm yecarvedilol uye mamwe ese ane hukama makomisheni.

Column: 4.6-mm × 15-cm;5-µm kurongedza L7

Column tembiricha: 55 ℃

Kuyerera: 1 mL / min

Jekiseni saizi: 20 µL

Kukodzera kwehurongwa

Sample: System kukodzera mhinduro

Kukodzera zvinodiwa

Resolution: NLT 17 pakati pecarvedilol uye carvedilol inoenderana nekomboni C

Analysis

Samples: Yakajairwa mhinduro uye Sample mhinduro

Verenga chikamu chechikamu che carvedilol chine hukama A, carvedilol ine hukama B, carvedilol ine hukama C, carvedilol ine hukama D, carvedilol ine hukama E, uye chero humwe hutsvina hwemunhu muchikamu cheCarvedilol chakatorwa:

Mhedzisiro = (rU/rS) × (CS/CU) × 100

rU	=	peak mhinduro yemukomboni unoenderana unoenderana kana chero kumwe kusachena kubva kuSample solution
rS	=	peak mhinduro yekomboni inowirirana inoenderana kubva kuStandard solution.Kuti uverenge chikamu chechero imwe tsvina yega yega shandisa peak mhinduro ye carvedilol.
CS	=	kusanganiswa kweiyo inoenderana inobatana mukomisheni muStandard solution (mg/mL).Kuti uverenge chikamu chezvimwe zvipi zvisina kuchena zveCS, shandisa kusungirirwa kweUSP Carvedilol RS.
CU	=	kusangana kweCarvedilol muSample solution (mg/mL)

Maitiro ekugamuchira: Ona Tafura 1.

Tafura 1

Zita	Relative Retention Time	Maitiro ekugamuchira, NMT (%)
Carvedilol inoenderana nechikamu Ea	0.35	0.1
Carvedilol yakabatana musanganiswa Ab	0.52	0.1
Carvedilol bisalkylpyrocatechol derivative (kana iripo)c	0.70	0.15
Carvedilol	1.0	-
Carvedilol inoenderana nechikamu Cd	3.6	0.02
Carvedilol yakabatana musanganiswa De	5.0	0.1
Carvedilol yakabatana musanganiswa Bf	8.5	0.1
Chero kumwe kusachena kwemunhu	-	0.10
Zvose zvisina kuchena	-	0.5g
a 2-(2-Methoxyphenoxy) ethyl amine. b 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2 -ol. c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol). d 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. e 4-(Oxiran-2-ylmethoxy) -9H-carbazole. f 3,3¢-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g Rega chero kusachena kupi zvako kuri pasi pe0.01%.

• Organic Kusachena, Maitiro 2

Mhinduro A: Acetonitrile uye trifluoroacetic acid (100:0.1)

Mhinduro B: Trifluoroacetic acid nemvura (0.1:100)

Diluent: Acetonitrile, trifluoroacetic acid, uye mvura (22:0.1:78)

Nharembozha: Ona Tafura 2

Tafura 2

Nguva (min)	Solution A (%)	Mhinduro B (%)
0	22	78
20	22	78
33	38	62
45	38	62
55	55	45
65	55	45
68	22	78
80	22	78

Kukodzera kweSystem mhinduro: 1.0 mg/mL yeUSP Carvedilol System Yakakodzera Musanganiswa RS muDiluent

Sample solution: 1 mg/mL yeCarvedilol muDiluent

Chromatographic system

(Ona Chromatography <621>, System Suitability.)

Modhi: LC

Detector: UV 240 nm

Column: 4.6-mm x 15-cm;5-µm kurongedza L68

Column tembiricha: 30 ℃

Kuyerera kweyero: 1.4 mL/min

Jekiseni saizi: 20 µL

Kukodzera kwehurongwa

Sample: System kukodzera mhinduro

Kukodzera zvinodiwa

Resolution: NLT 1.8 pakati pecarvedilol uye carvedilol inoenderana nekamu F

Analysis

Muenzaniso: Sample solution

Verenga chikamu chekusachena kwega kwega muchikamu cheCarvedilol chakatorwa:

Mhedzisiro = (rU/rT) × 100

rU	=	peak mhinduro yekusachena yega yega muSample solution
rT	=	hwerengedzo yemhinduro dzese dzepamusoro mumhinduro yeSample

Maitiro ekugamuchira: Ona Tafura 3.

Tafura 3

Zita	Hama Kuchengeta Nguva	Kubvuma Maitiro, NMT (%)
Carvedilol yakabatana musanganiswa Aa	0.7	0.1
Carvedilol	1.0	-
Carvedilol inoenderana nechikamu Fb	1.2	0.1c
N-Isopropylcarvedilold	1.6	0.1
Carvedilol inoenderana nechikamu Ce	1.8	0.02
Carvedilol yakabatana musanganiswa Bf	2.1	0.1
Biscarbazoleg	3	0.1
Chero kumwe kusachena kwemunhu	-	0.1
Zvose zvisina kuchena	-	0.5
a 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9Hcarbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2-ol . b 1-(2-(2-Methoxyphenoxy)ethylamino) -3-(6,7,8,9-tetrahydro-5H-carbazol-4-yloxy)propan-2-ol. c Uku kusachena kunoyerwa uchishandisa maitiro ari pasi peOrganic Impurities, Maitiro 3: Carvedilol Inoenderana Compound F. d 1-(H-Carbazol-4-yloxy) -3-[[2-(2-methoxyphenoxy) ethyl]N-isopropylamino] -2-propanol. e 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. f 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g 1,3-Bis-(9H-carbazol-4-yloxy) -2-propanol.

• Organic Kusachena, Maitiro 3: Carvedilol Inoenderana Musanganiswa F (kana iripo)

Mhinduro A: Trifluoroacetic acid nemvura (0.5:100)

Mhinduro B: Methanol uye trifluoroacetic acid (100:0.5)

Diluent: Mvura neacetonitrile (1:1)

Nharembozha chikamu: Solution A uye Solution B (65:35)

Sistimu yekukodzera mhinduro: 1.5 mg/mL yeUSP Carvedilol System Yakakodzera Musanganiswa RS muDiluent

Sample solution: 1.5 mg/mL yeCarvedilol muDiluent yakagadzirirwa sezvinotevera.Shandisa inenge 1.9 mL yeDiluent pamg yeCarvedilol, uye sonicate muchidimbu kuti ifambise kuparara.

Chromatographic system

(Ona Chromatography <621>, System Suitability.)

Modhi: LC

Detector: UV 226 nm

Column: 4.6-mm × 30-mm;3-µm kurongedza L7

Column tembiricha: 40 ℃

Kuyerera: 2 mL / min

Jekiseni saizi: 10 µL

Kukodzera kwehurongwa

Sample: System kukodzera mhinduro

Kukodzera zvinodiwa

Resolution: NLT 2.0 pakati pecarvedilol uye carvedilol inoenderana nekamu F

Analysis

Muenzaniso: Sample solution

Verengai muzana ye carvedilol inoenderana nekamu F muchikamu chemuenzaniso wakatorwa:

Mhedzisiro = (rU/rT) × (1/F) × 100

rU	=	peak mhinduro ye carvedilol inoenderana nekamu F kubva kuSample solution
rT	=	Huwandu hwemhinduro dzepamusoro dzecarvedilol uye carvedilol inoenderana nekamu F kubva kuSample solution.
F	=	hama mhinduro chinhu, 1.1

Maitiro ekugamuchira: NMT 0.1%

ZVIYEDZO ZVAKANAKA

• Kurasikirwa paKuomesa <731>: Pukuta sampuli pa105℃ kwemaawa matatu: inorasikirwa neNMT 0.5% yehuremu hwayo.

ZVIMWE ZVINODIWA

• Kurongedza uye Kuchengeta: Chengetedza mumidziyo yakaoma, uye chengeta patembiricha yekamuri inodzorwa.

• Kuisa Mazita: Kana bvunzo yeOrganic Impurities neHPLC isiri Procedure 1 ikashandiswa, ipapo kunyora kunotaura bvunzo inoteedzerwa nechinyorwa.

• USP Reference Standards <11>

USP Carvedilol RS

USP Carvedilol Inoenderana Compound A RS
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2- ol.
C36H43N3O7 629.74

USP Carvedilol Inoenderana Necompound B RS
3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
C39H39N3O6 645.74

USP Carvedilol Inoenderana Necompound C RS
1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
C31H32N2O4 496.60

USP Carvedilol Inoenderana Musanganiswa D RS
4-(Oxiran-2-ylmethoxy) -9H-carbazole.
C15H13NO2 239.27

USP Carvedilol Inoenderana Necompound E RS
2-(2-Methoxyphenoxy)ethyl amine.
C9H13NO2 167.21

USP Carvedilol System Yakakodzera Musanganiswa RS
Musanganiswa weinenge 0.1% carvedilol inoenderana musanganiswa F (1-(2-(2-Methoxyphenoxy)ethylamino) -3-(2,3,4,9-tetrahydro-1H-carbazol-5-yloxy)propan-2-ol) mune matrix ye carvedilol drug substance.