Risperidone CAS 106266-06-2 Assay 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri weRisperidone (CAS: 106266-06-2) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Risperidone,Please contact: alvin@ruifuchem.com
| Chemical Name | Risperidone |
| Mashoko anoreva zvakafanana | 3-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl]ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1 ,2-a]pyrimidin-4-one;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 106266-06-2 |
| Molecular Formula | C23H27FN4O2 |
| Molecular Weight | 410.49 g/mol |
| Melting Point | 170.0 kusvika 174.0 ℃ |
| Density | 1.38±0.10 g/cm3 |
| Hazard Kirasi | 6.1;Chepfu |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Zvinotsanangurwa | Results |
| Chitarisiko | Ichena kusvika kuOff-White Powder | Zvinoenderana |
| Identification A | Infrared Absorption | Zvinoenderana |
| Kuzivikanwa B | Nguva Yekuchengeta: Inopindirana neReference Substance | Zvinoenderana |
| Kurasika paKuomesa | <0.50% | 0.12% |
| Residue paIgnition | <0.10% | 0.07% |
| Heavy Metals | <0.001% | <0.001% |
| Related Compounds | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Chero Kusachena Kusingazivikanwe | <0.10% | <0.10% |
| Zvose Zvisina Kuchena | <0.30% | <0.30% |
| Assay | 98.0 ~ 102.0% (Yakaverengerwa pane Yakaomeswa Basis) | 100.52% |
| Mhedziso | Chigadzirwa chakaedzwa uye chinoenderana neUSP 35 Standard | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Risperidone
C23H27FN4O2 410.48
4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-one [106266-06-2].
»Risperidone ine kwete pasi pe98.0 muzana uye kwete kupfuura 102.0 muzana yeC23H27FN4O2, yakaverengerwa pane yakaomeswa.
Kurongedza uye kuchengetedza- Chengetedza mumidziyo yakavharwa zvakanaka.Chengetedza pane tembiricha yekamuri.
USP Reference mwero <11>-
USP Risperidone RS
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-imwe 410.48 CAS-106266-06-2
USP Risperidone System Kukodzera Musanganiswa RS
Iine risperidone uye inenge 0.2% yeimwe neimwe yeinotevera:
Z-Oxime-3-[2--[4-[(Z)-(2,4-difluorophenyl))(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9- tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-imwe.
9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-imwe.
6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-imwe.
[Cherechedza-Musanganiswa uyu une risperidone, Z-oxime, 9-hydroxyrisperidone, uye 6-methylrisperidone.]
Identification-
A: Infrared Absorption <197K>.
B: Nguva yekuchengeta yepamusoro-soro muchromatogram yeAssay kugadzirira inoenderana neiyo mukromatogram yeStandard gadziriro, sezvakawanikwa muAssay.
Kurasikirwa pakuomeswa <731> - Dry in vacuum pa80 kwemaawa mana: inorasikirwa kwete kupfuura 0.5% yehuremu hwayo.
Residue pakubatidza <281>: kwete kupfuura 0.1%, 2.0-g test specimen iri kushandiswa.
Heavy metals, Nzira II <231>: 0.001%.
Related compounds-
Buffer solution, Solution A, Solution B, Mobile phase, Diluent, System suitability solution, uye Chromatographic system-Gadzirira sezvinorayirwa muAssay.
Yakajairwa mhinduro-Shandisa iyo Yakajairwa gadziriro, yakagadzirirwa sezvakarairwa muAssay.
Test solution-Shandisa gadziriro yeAssay.
Procedure-Baya mavhoriyamu akaenzana (angangoita gumi µL) eiyo Standard solution uye Test mhinduro muchromatograph, uye rekodha chromatogram.Ziva tsvina uchishandisa nguva dzekuchengetedza dzakapihwa muTebhurari yekutanga, uye meya mhinduro dzepamusoro.Verengai muzana yerisperidone yega yega ine hukama muchikamu cheRisperidone inotorwa neformula:
100(CS /CU)(rU / rS)(1/F)
umo CS uye CU ndiwo maratidziro, mumg per mL, yerisperidone muStandard solution uye Test solution zvichiteerana;rU ndiyo nzvimbo yepamusoro yekusachena yega yega inowanikwa kubva kuMuedzo mhinduro;rS ndiyo nzvimbo yepamusoro yerisperidone inowanikwa kubva kune Standard solution;uye F ndiyo inoenderana nemhinduro yechinhu chekusachena kwega kwega kune risperidone.Mukuwedzera pakusapfuura miganhu muTebhu 1, kwete kupfuura 0.10% yehupi husina kuchena husingazivikanwi (shandisa F kukosha kwe1.0) inowanikwa uye kwete kupfuura 0.30% yehutsvina hwose inowanikwa.Rega nhongonya dzekusachena dziri pasi pe0.05%.
Tafura 1
Related Compound Relative Retention Time (RRT) Relative Response Factor (F) Limit (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2--[4-[(E)-(2,4-Difluorophenyl))(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-imwe
2--[2--[4-[(Z)-) (2,4-Difluorophenyl) (hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-imwe
3 (9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-imwe
4 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidin-4-imwe
5 (6RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-imwe
Kuongorora-
Buffer solution- Dissolve 15.4 g yeammonium acetate mu1 L yemvura.Rongedza ne10% acetic acid kune pH ye6.5, uye sanganisa.
Solution A-Sanganisa 100 mL yeBuffer solution ine 150 mL yemethanol mu1000-mL volumetric flask, uye dilue nemvura kusvika kuhuwandu.
Solution B- Sanganisa 100 mL yemushonga weBuffer ne850 mL yemethanol mu1000-mL volumetric flask, wodzikinura nemvura kusvika kuhuwandu.
Nharembozha chikamu-Shandisa akasiyana musanganiswa weSolution A uye Solution B sekurairwa kweChromatographic system.Ita zvigadziriso kana zvichidikanwa (ona System Suitability pasi peChromatography 621).
Diluent-Sanganisa 100 mL yeBuffer solution ine 900 mL yemvura uye 1000 mL yemethanol.
Kukodzera kweSystem solution-Gadzirira 1 mg per mL solution yeUSP Risperidone System Suitability Mixture RS in Diluent.
Kugadzirira kwakajairwa-Dyisa huremu hwakayerwa nemazvo hweUSP Risperidone RS muDiluent, uye dilute zvine mutsindo, uye nhanho kana zvichidikanwa, neDiluent kuti uwane mhinduro ine huwandu hunozivikanwa hunosvika 1.0 mg per mL.
Kugadzirira kweAssay-Dyisa huremu hwakayerwa nemazvo eRisperidone muDiluent, uye dilute quantitatively, uye nhanho kana zvichidikanwa, neDiluent kuti uwane mhinduro ine huwandu hunosvika 1.0 mg per mL.
Chromatographic system (ona Chromatography <621>)- Iyo chromatograph yemvura ine 275-nm detector uye 4.6-mm × 10-cm column ine 3-µm packing L1.Chiyero chekuyerera chinenge 1.5 mL paminiti.Iko kupisa kwembiru inochengetwa pa 35. Chromatograph inorongwa sezvinotevera.
Nguva (maminetsi) Solution A (%) Solution B (%) Elution
0–1 70 30 isocratic
1–20 70®5 30®95 linear gradient
20–25 5 95 chisocratic
25–27 5®70 95®30 linear gradient
27–35 70 30 re-equilbrationBaya iyo Sistimu kukodzera mhinduro.Rekodha mhinduro dzepamusoro sekutaurirwa kweProcedure, uye tsvaga nhongonya dzinokonzerwa neZ-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, uye risperidone uchishandisa nguva dzekuchengetedza (RRT) kubva paTafura 1;chisarudzo, R, pakati peZ-oxime ne9-hydroxyrisperidone haisi pasi pe2.8;iyo muswe werisperidone haisi kupfuura 1.5;uye kutsauswa kwakayerwa kwemajekiseni akadzokorora hakupfuuri 2.0% yerisperidone peak.
Maitiro- Baira mavhoriyamu akaenzana (angangoita 10 µL) eChimiro chegadziriro uye gadziriro yeAssay muchromatograph, uye kuyera mhinduro dzerisperidone peak.Verenga huwandu, muchikamu cheC23H27FN4O2, muchikamu cheRisperidone chakatorwa neformula:
100(CS /CU)(rU / rS)
umo CS uye CU ndiwo maitiro, mu mg per mL, ye risperidone mu Standard kugadzirira uye kugadzirira kweAssay, maererano;uye rU nerS ndiwo mhinduro dzepamusoro dzakawanikwa kubva mukugadzirira kweAssay uye gadziriro yeStandard, zvichiteerana.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Risk Codes R25 - Chepfu kana ikamedzwa
R23/24/25 - Muchetura nekufema, kubata neganda uye kana kumedzwa.
R11 - Yakanyanya Kupisa
Tsanangudzo Yekuchengetedza S28 - Mushure mekusangana neganda, geza nekukurumidza nesipo yakawanda.
S36 - Pfeka zvipfeko zvinodzivirira zvakakodzera.
S45 - Kana pakaitika tsaona kana ukanzwa usinganzwe zvakanaka, tsvaga zano rekurapa nekukasira (ratidza chinyorwa pese pazvinogoneka.)
S36/37 - Pfeka zvipfeko zvekudzivirira zvakakodzera uye magurovhosi.
S16 - Chengetedza kure nenzvimbo dzekudzima.
UN IDs 3249
WGK Germany 3
RTECS UV1164800
HS Code 2934999099
Kirasi yeNjodzi 6.1(a)
Packing Group II
Risperidone (CAS: 106266-06-2) ine antagonism mhedzisiro pa5HT2 receptors uye D2 receptors.Risperidone inoshandiswa kune yakaoma uye isingaperi schizophrenia.Antipsychotic mishonga.Risperidone inoshandiswa kurapwa kweacute uye isingaperi schizophrenia uye zvimwe zvakasiyana-siyana zvepfungwa zviratidzo zvakajeka (zvakadai sekufungidzira, fungidziro, kusagadzikana kwepfungwa, ruvengo, kufungirana) uye zviratidzo zvisina kunaka (sekusateerera, kusava nehanya kwepfungwa uye kusava nehanya kwevanhu, vashoma. mazwi).Uyewo inogona kuderedza zviratidzo zvine chokuita neschizophrenia (zvakadai se: kuora mwoyo, mhosva, kufunganya).Kune varwere vane Risperidone inoshanda kune acute kurapwa, muchikamu chekuchengetedza chekurapa, iyo Risperidone inogona kuramba ichitamba yayo yekiriniki efficacy.Risperidone, naizvozvo, ine chiito chekurapa pane zvose zvakanaka uye zvisina kunaka zviratidzo zveschizophrenia uye inogadzira zvishoma zvishoma zvinokonzerwa nemigumisiro kunyanya extrapyramidal zviratidzo zvichienzaniswa neanowanzo shandiswa yakachena D2 antagonist antipsychotics.Iyo ine zvakare mukana wekutonga kwekubvisa doro uye kupindwa muropa necocaine.
