4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid CAS 123654-26-2 Prucalopride Succinate Intermediate Purity ≥98.0% (HPLC)

Tsanangudzo Pfupi

4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid

CAS: 123654-26-2

Kuchena: ≥98.0% (HPLC)

Chitarisiko: Off-White kusvika Chiedza-Red Solid

Pakati pePrucalopride Succinate (CAS: 179474-85-2)

Bata: Dr. Alvin Huang

Nharembozha/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Tsanangudzo:

Shanghai Ruifu Chemical ndiyo inotungamira kugadzira 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Prucalopride Succinate Intermediates,Please contact: alvin@ruifuchem.com

Prucalopride Succinate Intermediates:

Chemical Properties:

Chemical Name 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid
Mashoko anoreva zvakafanana 4-Amino-5-Chlorocoumaran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydrobenzo[b]furan-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-1-Benzofuran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydro-7-Benzofurancarboxylic Acid;Prucalopride Impurity A;Prucalopride Succinate Kusachena-2
Stock Status MuStock, Commercial Production
Nhamba yeCAS 123654-26-2
Molecular Formula C9H8ClNO3
Molecular Weight 213.62 g/mol
Melting Point 242 ℃ (Zvita.)
Boiling Point 406.5±45.0℃
Density 1.566
COA & MSDS Available
Origin Shanghai, China
Category Pakati pePrucalopride Succinate (CAS: 179474-85-2)
Brand Ruifu Chemical

Zvinotsanangurwa:

Items Kuongorora Maitiro Results
Chitarisiko Off-White kusvika Chiedza-Red Solid Chiedza-Chitsvuku Chakasimba
Mvura naKarl Fischer ≤1.00% 0.35%
Residue paIgnition <0.20% 0.08%
Masimbi anorema (Pb) ≤20ppm <10ppm
Kusachena Kumwechete ≤1.00% Zvinoenderana
Zvose Zvisina Kuchena ≤2.00% Zvinoenderana
Kuchena / Analysis Method ≥98.0% (HPLC) 99.6%
Infrared Spectrum Inopindirana neChimiro Zvinoenderana
1 H NMR Spectrum Inopindirana neChimiro Zvinoenderana
Mhedziso Chigadzirwa chacho chakaedzwa uye chinoenderana nezvakapihwa

Pakeji/Kuchengeta/Shipping:

Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.

123654-26-2 - Test Method:

Ichi chigadzirwa chinonzi 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid, zvinyorwa zveC12H12ClNO4 hazvifaniri kunge zvisingasviki 98.0%, zvakaverengwa pane anhydrous basis.
[Properties] Ichi chigadzirwa chakadzima-chena kune chakajeka-tsvuku chakasimba.
[Tarisa]
Tora chiyero chakakodzera chechigadzirwa ichi (chinenge 0.5g) chemvura, wedzera solvent (methanol: N, N-dimethylformamide = 50:50), uye uiputse maererano nekugadzirisa nzira yemvura (Appendix Ⅷ M, nzira yekutanga A).Shandisa madonhwe ebvunzo aFisher kuona kudzamara mhinduro yachinja kubva kuyero yero kuenda kune yakatsvuka-brown inoratidza kupera, uye itisa imwe bvunzo isina chinhu.Verenga maererano neinotevera fomula: iyo yemukati yemvura haifanire kudarika 1.00%.
Hunyoro hwemukati (%) = (AB) F/W×100%
Ipo, A ndiyo vhoriyamu yeFisher's fluid inopedzwa nechigadzirwa chekuyedza (ml);
B ivhoriyamu yeFisher's test fluid inopedzwa nenzvimbo isina chinhu, ml;
F uremu hweFisher's test solution yakaenzana nemvura pa1ml, ​​mg;
W ndiyo huremu hwechigadzirwa chekuedza, mg
Related substance
Zvinoenderana neiyo nzira iri pasi pe "Content kuyerwa chinhu", kana paine kusachena kwakakwira muchromatogram yemhinduro yekuyedza, nzvimbo yepamusoro yekusachena kumwe chete haifanire kunge yakakura kudarika kagumi (1.0%) yenzvimbo huru yepamusoro yekutonga. mhinduro, uye hwerengedzo yenzvimbo yepamusoro yetsvina yese haifanire kunge yakakura kudarika ka20 (2.0%) yenzvimbo huru yepamusoro-soro yekugadzirisa mhinduro.
[Kutsunga Kwemukati] Zvinoenderana nepamusoro pekuita liquid chromatography (Appendix VI D).
Octadecylsilane bonded silica gel yakashandiswa seyekuzadza chromatographic mamiriro uye system yekukodzera bvunzo.Phosphate buffer solution (1.36g potassium dihydrogen phosphate, yakanyungudutswa ultrasonic mumvura 1L, phosphoric acid yakagadziridzwa kuPH 3.0) yakashandiswa se mobile phase A. Acetonitrile is mobile phase B, uye gradient elution inoitwa maererano netafura inotevera:
Nguva (min) Nharembozha chikamu A chinotakurika chikamu B
0 80 20
15 80 20
30 50 50
45 50 50
Iyo yekuona wavelength yaive 254 nm.Chiyero chekuyerera chaive 1.0 ml / min.Nhamba yezvinyorwa zvinyorwa haisi pasi pe2000 maererano nepamusoro pe4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid.
Iyo yepamusoro yefuranoformic acid haisi pasi pe2000.
Determination method:
Tora 10mg yechigadzirwa chekuedza, uiyere nenzira kwayo, uise muA 10ml bhodhoro, inyungudise iyo ultrasonic ne mobile phase A-mobile phase B (70:30) seye solvent, dilute kusvika pachiyero, zunza zvakanaka, uye gadzirira a mhinduro ine huwandu hwe1mg/ml.20 l yechokwadi yakaiswa mu chromatograph yemvura, uye chromatogram yakanyorwa.Iyo huru yepamusoro peak kuchena yaive isiri pasi pe98.0% zvinoenderana nepamusoro penzvimbo yekujairisa nzira
Column: Dionex Acclaim C18, 4.6 * 250mm, 5um
Column tembiricha: 40 ℃
Kuyerera kweyero: 1.0ml/min
Kuonekwa wavelength: 254nm
Saizi yemuenzaniso: 10μL

Zvakanakira:

Yakakwana Capacity: Inokwana zvivakwa uye matekiniki

Professional Service: Imwe inomira kutenga sevhisi

OEM Package: Tsika pasuru uye label iripo

Fast Delivery: Kana iri mukati me stock, mazuva matatu ekutumira anovimbiswa

Yakagadzika Supply: Chengetedza zvine musoro stock

Tsigiro yehunyanzvi: Tekinoroji mhinduro iripo

Tsika Synthesis Service: Kubva pamagiramu kusvika makirogiramu

Hunhu Hwepamusoro: Yakagadzira yakakwana yemhando yekusimbisa system

FAQ:

Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.

Application:

4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2), inogona kushandiswa sepakati pekugadzirisa kwePrucalopride Succinate (CAS: 179474-85-2), yakasarudzwa 5-HT4 receptor agonist inoshandiswa inoshanda kune kusingaperi kuvimbiswa.Prucalopride Succinate, yekutanga-mu-kirasi dihydrobenzofurancarboxamide, inosarudza serotonin (5- HT4) receptor agonist.Mushonga uyu, unotengeswa pasi pezita rechiratidzo Resolor®, une enterokinetic chiitiko uye wakagadzirwa neBelgian-based pharmaceutical femu Movetis.Prucalopride inoshandura colonic motility mapatani kuburikidza ne serotonin 5-HT4 receptor kukurudzira, zvichikonzera iyo yepakati propulsive simba rekuita defecation.

Nyora meseji yako pano uye titumire kwatiri