2-Cyanophenylboronic Acid 1,3-Propanediol Ester CAS 172732-52-4 Perampanel Intermediate Purity>99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira 2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) ine mhando yepamusoro, yepakati pePerampanel (CAS: 380917-97-5).Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Perampanel yepakati, Please contact: alvin@ruifuchem.com
| Chemical Name | 2-Cyanophenylboronic Acid 1,3-Propanediol Ester |
| Mashoko anoreva zvakafanana | 2-Cyanobenzeneboronic Acid 1,3-Propanediol Ester;2-(1,3,2-Dioxaborinan-2-yl)benzonitrile |
| Nhamba yeCAS | 172732-52-4 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C10H10BNO2 |
| Molecular Weight | 187.01 |
| Melting Point | 46.0 ~ 51.0℃ (lit.) |
| Density | 1.13±0.10 g/cm3 |
| Solubility | Soluble muMethanol |
| Kugadzikana | Hygroscopic |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Ichena kusvika kuChiedza Yero Hupfu kusvika kuCrystal |
| Kuchena / Analysis Method | >99.0% (HPLC) |
| Kurasika paKuomesa | <0.50% |
| Residue paIgnition | <0.20% |
| Kusachena Kumwechete | <0.50% |
| Zvose Zvisina Kuchena | <1.00% |
| Heavy Metals (as Pb) | <20ppm |
| Test Standard | Enterprise Standard |
| Usage | Pakati Perampanel (CAS: 380917-97-5) |
Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro.
Hazard Symbols Xi - Irritant
Risk Codes
R20/21/22 - Inokuvadza nekufema, kubata neganda uye kana ikamedzwa.
R36/37/38 - Kushungurudza maziso, kufema system uye ganda.
Tsanangudzo Yekuchengetedza
S26 - Kana wasangana nemaziso, simbura nekukasira nemvura yakawanda uye tsvaga mazano ekurapwa.
S36/37/39 - Pfeka zvipfeko zvekudzivirira zvakakodzera, magurovhosi uye kudzivirira maziso/chiso.
UN IDs 3439
WGK Germany 3
TSCA Nha
Hazard Note Irritant
2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) inoshandiswa mukugadzirwa kwePerampanel (CAS: 380917-97-5), anopikisa AMPA receptor.Perampanel (ane rezenisi muna 2012) chizvarwa chechitatu cheAED chinozivikanwa nezita remhando yeFycompa® (Eisai, Hatfield) muUK neBanzel® (Eisai, Hatfield) muUSA.Muna Gumiguru 2012, iyo US FDA yakabvumidza perampanel kurapwa kwechikamu chekutanga pfari muvarwere vane pfari vangangoita makore gumi nemaviri.Perampanel ndiye wekutanga AMPA receptor antagonist kugamuchira FDA mvumo seAED.AMPA glutamate receptors anowanikwa zvakanyanya pane postsynaptic neurons muuropi.Semunhu anosarudza, asingakwikwidzi anopikisa we AMPA, parampanel inodzivirira ion chiteshi kuvhurwa uye inoderedza kupararira kwekuita.Perampanel yakatenderwa neEuropean EMA neUS FDA muna Chikunguru naGumiguru 2012 zvakateerana, inoshandiswa kurapa adjuvant yevarwere vane pfari zvishoma vanopfuura makore gumi nemaviri vane kana vasina chechipiri systemic pfari.Musi waChikumi 22, 2015, Eisai akazivisa kuti US FDA yakabvumidza kuwedzera kwechiratidzo chePirenparanide hydrate (Fycompa) semushonga weadjuvant wepakutanga wakazara tonic-clonic seizures muvarwere vane pfari vane makore gumi nemaviri zvichikwira.
