Vardenafil Yepakati CAS 224789-21-3 Kuchena > 99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd ndiyo inotungamira kugadzira 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-imwe. (CAS: 224789-21-3) nehupamhi hwepamusoro, huri pakati peVardenafil.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Vardenafil Intermediates,Please contact: alvin@ruifuchem.com
| Chemical Name | 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-imwe |
| Mashoko anoreva zvakafanana | Vardenafil Dessulfonyl Kusachena;2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazo[5,1-F][1,2,4]triazin-4-one;Vardenafil Propyl Imidazotriazinone Kusachena;Vardenafil Inoenderana Musanganiswa 1 |
| Stock Status | MuStock, Kukwanisa Kugadzira Matani maviri pamwedzi |
| Nhamba yeCAS | 224789-21-3 |
| Molecular Formula | C17H20N4O2 |
| Molecular Weight | 312.37 g/mol |
| Melting Point | 142.0~148.0℃ |
| Density | 1.26±0.10 g/cm3 |
| Kuchengetedza Kwenguva Yakareba | Nzvimbo Inotonhorera & Yakaoma (2~8℃) |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Zvinotsanangurwa | Results |
| Chitarisiko | Off-White kusvika Pale Yellow Powder | Off-White Powder |
| Melting Point | 142.0~148.0℃ | 146.0~147.0℃ |
| Kurasika paKuomesa | <1.00% (102℃, 3h) | 0.23% |
| Masimbi anorema (Pb) | ≤20ppm | <20ppm |
| Kuchena / Analysis Method | >99.0% (HPLC) | 99.79% |
| 1H NMR Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chakaedzwa uye chinoenderana nezvakapihwa | |
| Application | Pakati peVardenafil / Vardenafil Hydrochloride | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza chezuva uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
1. Chitarisiko: Isa sampu pabepa jena uye tarisa kutaridzika, kubva-kuchena kusvika kucheneruka yehupfu.
2. Ongororo:
2.1 Melting Point kutsunga maererano nemutemo (Chinese Pharmacopoeia 2010 Edition II Appendix ⅥC) Melting Point is 142.0~148.0℃.
2.2 Kurasikirwa Pakuomesa: Kutsunga maererano nemutemo (Appendix ⅧL, Chikamu II, 2010 Edition yeChinese Pharmacopoeia).Kunyatso kuyera huwandu hwakakodzera hwechigadzirwa ichi, yakaoma pa102 ℃ kwemaawa matatu, kurasikirwa nekurema hakuzopfuure 1.00%.
2.3 Heavy Metals: Kutsunga maererano nemutemo (People's Republic of China Pharmacopoeia 2010 Edition, Chikamu II Appendix ⅧH) Kutsunga nenzira yechipiri.
Precision inorema 1.0g yechigadzirwa chebvunzo, ichipisa zvishoma nezvishoma kusvika yazara carbonized, inotonhorera, wedzera 0.5-1.0ml sulfuric acid, ita kuti inyoro, kupisa pakupisa kwakadzika kusvika sulfuric acid yapera, wedzera 0.5ml nitric acid, steam yakaoma, kusvikira iyo nitrogen oxide vapor yapera, inotonhorera, inopisa pa 500-600 ℃ kusvika zvachose carbonized, inotonhorera, wedzera 2ml hydrochloric acid, Mushure mekuoma mumvura yekugezera, wedzera 15ml mvura, donhedza mhinduro yeammonia kusvikira yava kurerekera kune phenolphthalein chiratidzo. mhinduro, wedzera 2ml acetate buffer (ph3.5), uye zvishoma kupisa nyungudika, fambisa iyo Nachner colorimetric chubhu, uye dilue mu 25ml nemvura.Tora imwe reagent yekugadzirira mhinduro yebvunzo, woipisa mundiro yeporcelain, wedzera 2ml acetate buffer (PH3.5) uye 15ml mvura kusvika pakupisa zvishoma Mushure mekunyunguduka, fambisa Nath colorimetric chubhu, wedzera huwandu hweyakajairwa lead solution, wobva wadzikira nemvura kusvika pa25ml.Colorimetric kuyedza inoitwa pakati peyedzo mhinduro uye yakajairwa mhinduro yekuwana.Standard solution kugadzirira maererano (People's Republic of China Pharmacopoeia 2010 edition II Appendix Ⅷ Heavy metal test method) nzira yekutanga.Heavy metals haifanire kudarika zvikamu makumi maviri pamiriyoni.
3. Kuchena: Maererano nepamusoro pekuita liquid chromatography, yakatemwa maererano nemutemo (Chinese Pharmacopoeia 2010 edition II Appendix VD).
Chromatographic mamiriro:
Column: C18, 200mm×4.6mm, 5μm;
Nharembozha: Phosphate buffer (inorema 2.72g potassium dihydrogen phosphate, wedzera mvura kuti iparadze uye iwedzere kusvika 1000ml, gadzirisa pH = 3.5) : acetonitrile: = 35:65;
Kuonekwa wavelength: 254nm;
Kuyerera kweyero: 1.0ml/min.
Nzira yekutsunga: Tora inenge 30mg yechigadzirwa ichi, chiyera nemazvo, dilue nechikamu chenhare kuti uite concentration inosvika 0.3mg/ml, tora 20μl muchromatograph yemvura, rekodha chromatogram.Zvinoenderana nenzvimbo normalization nzira, kuchena hakusi pasi pe99.0%.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one (CAS: 224789-21-3) iri pakati pe Vardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).Vardenafil iyi PDE5 inhibitor itsva yakatangwa kuti irapwe nemuromo yevarume erectile dysfunction uye ine maitiro akafanana akafanana ne sildenafil (Viagra), iyo yaiva yekutanga PDE5 inhibitor yakaunzwa muna 1998 nokuda kwechiratidzo ichi.
Vardenafil ndiye mumiririri wechipiri kuti atengeswe uye ane mukana wekuti nguva yake yekutanga haina kuderedzwa nekutora mishonga padumbu rakazara .Iine 30 nguva yakawanda se inhibitor yePDE5 (inoreva IC50, 3.9 nM) kupfuura sildenafil uye 10 nguva yakawanda kupfuura tadalafil, ine sarudzo huru (> 1,000 times) yePDE5 yevanhu pane PDE2, PDE3, uye PDE4 uye kusarudzwa kuri pakati nepakati (>80 nguva) yePDE1.Iyo PDE inhibitory selectivity uye zvese zviri zviviri in vitro uye in vivo potency yeiyo itsva PDE5 inhibitor vardenafil.Vardenafil yakanyatsodzivisa hydrolysis ye cGMP nePDE5, ine IC50 ye 0.7 nM (sildenafil 6.6 nM).Iyo IC50 yevardenafil yePDE1 yaive 180 nM, yePDE6 11 nM, uye yePDE2, PDE3 uye PDE4 kupfuura 1,000 nM.
