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Apixaban Yepakati CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)
Ruifu Chemical ndiye anotungamira mutengesi weEthyl Chloro[(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) ine mhando yepamusoro, yepakati yeApixaban (CAS: 503612-47-3).Ruifu inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, madiki uye akawanda akawanda aripo.Tenga Apixaban pakati, E-mail: alvin@ruifuchem.com
| Chemical Name | Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate |
| Mashoko anoreva zvakafanana | Ethyl 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazono]acetate;(Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;2-Chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene];Apixaban-2;Apixaban Kusachena 3 |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 27143-07-3 |
| Molecular Formula | C11H13ClN2O3 |
| Molecular Weight | 256.69 g/mol |
| Melting Point | 94℃ |
| Density | 1.23 |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Category | Pakati peApixaban (CAS: 503612-47-3) |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Yero Yero kusvika Yero Hupfu | Zvinoenderana |
| Kurasika paKuomesa | <0.50% | 0.23% |
| Kuchena / Analysis Method | ≥99.0% (HPLC) | 99.3% |
| Infrared Spectrum | Inopindirana neChimiro | Zvinoenderana |
| 1 H NMR Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chacho chakaedzwa uye chinoenderana nezvakapihwa | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Rondedzero Yezvinonyungudutsa Zvinoshandiswa Mukugadzira
| Aihwa. | Zita | CAS Nha. | Molecular Formula |
| 1 | Ethyl Acetate | CAS: 141-78-6 | C4H8O2 |
| 2 | Dichloromethane | CAS: 75-09-2 | CH2Cl2 |
| 3 | Ethyl Doro | CAS: 64-17-5 | C2H5OH |
5.3.1 Chitarisiko: Inofanira kuva yehupfu yakatsvuka kusvika kuyero.Nepameso, isa huwandu hwakakwana hwechigadzirwa chekuyedza (pasina kuyera) mundiro yakachena yekristaro pane chena kumashure (senge bepa jena) pasi pechiedza chechisikigo.
5.3.2 Kuzivikanwa: 1H-NMR ine chimiro chakafanana nechiyero.10 ~ 15mg yemuenzaniso yakayerwa munyukireya magineti chubhu, uye 0.5mL yedeuterium DMSO yakawedzerwa kunyungudutsa zvizere sampu, uyezve yakayedzwa neyenyukireya magineti resonance chiridzwa chinodarika 400MHz.
5.3.3 Kurasika pakuomeswa : Weresa sampuli inenge 1.0g woiomesa kwemaawa matatu muovheni inoomesa pa85℃.Iyo chaiyo mashandiro ekuverenga kurasikirwa kwehuremu ichaitwa zvinoenderana nezvinopihwa zveSOP-AP-QC-002-01 yeKusarudza Kuomesa Weight Loss.
5.3.4.1 Chromatographic mamiriro:
Test reagents: 1) acetonitrile yechromatography 2) mvura yakacheneswa 3) phosphoric acid
Column: WondaCract ODS-2 4.6*250mm*5um (8520-39993)
Nharembozha chikamu: A: Kuyera nemazvo 1.0ml phosphoric acid uye 1000ml mvura, sefa ultrasonic degassing.
B: Acetonitrile.
Gradient maitiro: tafura inotevera
Nguva mbozha nhanho A (%) Nharembozha chikamu B (%)
3 90 10
10 25 75
20 0 100
25 0 100
Detector: 210nm
Column tembiricha: 35 ℃
Kuyerera kumhanya: 1.0ml/min
Saizi yemuenzaniso: 5µl
5.3.4.2 Kugadzirira kugadzirisa:
5.3.4.3 Diluent: acetonitrile
5.3.4.4 Mushonga usina chinhu: diluent ichashandiswa semushonga usina chinhu.
5.3.4.5 Test chigadzirwa mhinduro: Weresa chigadzirwa chebvunzo chinenge 12.5mg mu25ml volumetric bhodhoro woinyungudutsa ne diluent kusvika pachiyero.
5.3.4.6 Maitiro ekushanda: Mushure mokunge nheyo yechiridzwa yakagadzikana, jekiseni rimwe kusvika maviri remhinduro isina chinhu rinofambiswa mberi, uye ipapo mhinduro yechigadzirwa chekuedza inoongororwa.Iyo chromatogram inochengetwa uye inoongororwa, peak isina chinhu inobviswa, uye iyo huru yepamusoro peak kuchena uye kumwe kusachena mhedzisiro pachromatogram yechigadzirwa chebvunzo inorekodhwa nenharaunda normalization nzira.Mushure mekuongorora, chromatogram yakadhindwa.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Ethyl Chloro [(4-Methoxyphenyl) hydrazono]acetate (CAS: 27143-07-3) inoshandiswa sepakati mukugadzirwa kweApixaban (CAS: 503612-47-3).Apixaban rudzi rutsva rweoral factor Xa inhibitor yakabatanidzwa pamwe chete neBristol-Myers Squibb uye Pfizer.Zita rekutengesa ndiro Erroto.Irwo rudzi rutsva rwemuromo anticoagulant.Nekudzivisa yakakosha coagulation factor Xa, apixaban inogona kudzivirira thrombin kugadzirwa uye thrombosis.Apixaban yakagadzirwa neBristal-Myers squibb Company.Iyo ine yakanaka bioavailability uye yakakwirira kusarudza.Yakanyorwa muChina muna 2013. Apixaban yakachengeteka, mukana wekubatana kwezvinodhaka zvishoma, uye kune nzira dzakawanda dzekuzvibvisa, izvo zvinotarisirwa kushandiswa mumapoka anokosha anotambura nechirwere chechiropa kana kukanganisa kwetsvo.
![Apixaban Yepakati CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_-300x300.jpg)
