CAS 361442-04-8 Kuchena >99.0% (HPLC) API Featured Image

Purogiramu inonzi CAS 361442-04-8 Kuchena >99.0% (HPLC)

Tsanangudzo Pfupi

Synonyms: BMS-477118;Onglyza

CAS: 361442-04-8

Kuchena:> 99.0% (HPLC)

Kuonekwa: White Powder

API, High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com

Tumira email kwatiri

Product Detail

Product Tags

Tsanangudzo:

Ruifu Chemical Supply Related Intermediates
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Chemical Properties:

Mashoko anoreva zvakafanana	BMS-477118;Onglyza;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo[3.1.0]hexane-3-Carbonitrile;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxytricyclo [3.3.1.13,7]dec-1-yl)acetyl]-2-Azabicyclo[3.1.0]hexane -3-Carbonitrile
Nhamba yeCAS	361442-04-8
Nhamba yeCAT	RF-PI1991
Stock Status	MuStock, Kugadzirwa Kunokwira Kusvika Matani
Molecular Formula	C18H25N3O2
Molecular Weight	315.41
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	White Powder
Kunhuwa	Hunhu
identification	A: IR B: HPLC Kuchengeta Nguva
Kuchena / Analysis Method	>99.0% (HPLC)
Kujeka kweMvura Solution	Zviripachena, Zvisina Ruvara, Hapana Akamiswa Nyaya
Sieve Analysis	100% Kupfuura 80 Mesh
Melting Point	202.0~212.0℃
Kurasika paKuomesa	<0.50%
Sulfated Ash	<0.20%
Specific Rotation	+174.0°~+186.0°
Kusachena Kumwechete	<0.50%
Zvose Zvisina Kuchena	<1.00%
Heavy Metals	<10ppm
Arsenic (As)	<2.0ppm
Kutungamira (Pb)	<1.0ppm
Cadmium (Cd)	<1.0ppm
Residual Solvents	<100ppm
Residual Pesticide	Negative
Microbiology
Total Plate Count	<1000cfu/g
Yeast & Mold	<100cfu/g
E. Coli	Negative
S. Aureus	Negative
Salmonella	Negative
Sherufu Hupenyu	24 Mwedzi Kubva Kugadzirwa Zuva Kana Yakachengetwa Zvakanaka
Test Standard	Enterprise Standard
Usage	API;Type 2 Diabetes Mellitus

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro

Zvakanakira:

FAQ:

Application:

(BMS-477118) (CAS: 361442-04-8) ine simba, inosarudza, inodzokera shure, inokwikwidza uye inoshandiswa nemuromo dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor.BMS-477118 ine peotential yerudzi rwechipiri chirwere cheshuga mellitus research.BMS-477118Chirwere chechirwere cheshuga cherudzi rwechipiri chinogona kuita kuti pancreas ibudise insulin yakawanda mushure mekudya.Yakasvikwa nekubatana kweAstraZeneca neBristol-Myers Squibb Kambani uye ndeyeDPP-IV inhibitor.BMS-477118inotora basa kuburikidza nekudzivisa GLP-l kudzikira.GLP-I ndiwo mahomoni anogadzirwa mumatumbo mushure mekutora chikafu.Inogona kudzora secretion ye insulini uye kusimbisa kushandiswa kweglucose muzvikamu zveperipheral.Mushonga mumwe chete weBMS-477118 unogona kuvandudza kudzora shuga yeropa uye mishonga yakasanganiswa yeBMS-477118 ine Metformin, Sulfonylurea uye Thiazolidinediones inogona kuwedzera kurapa.Zvinotungamirira kungozi yakaderera ye hypoglycemia uye maitiro ayo akaipa akafanana ne placebo, kuratidza kushivirira kuri nani.Musi waChikunguru 31, 2009, BMS-477118 mapiritsi (Onglyza), mushonga mutsva wechirwere cheshuga cherudzi rwechipiri, wakatsvagirwa pamwe nekugadzira AstraZeneca neBristol-Myers Squibb wakatenderwa neUS FDA.Inogona kutorwa kamwe chete pazuva kurapa chirwere cheshuga chechipiri chakasanganiswa nekudzora Kudya uye kurovedza muviri.