Apixaban Yepakati CAS 503615-03-0 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-imwe Purity ≥99.0% (HPLC)
Ruifu Chemical ndiyo inotungamira kugadzira 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-one (CAS: 503615-03-0) nemhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Apixaban yepakati,Please contact: alvin@ruifuchem.com
| Chemical Name | 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-imwe |
| Mashoko anoreva zvakafanana | 3-(4-Morpholinyl) -1-(4-Nitrophenyl)-5,6-Dihydro-2(1H)-Pyridinone;5,6-Dihydro-3-(4-Morpholinyl) -1-(4-Nitrophenyl)-2(1H)-Pyridinone;Apixaban Pakati 3;Apixaban Kusachena 36;Apixaban Process Kusachena 1 |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 503615-03-0 |
| Molecular Formula | C15H17N3O4 |
| Molecular Weight | 303.31 g/mol |
| Melting Point | 165.0 ~ 170.0 ℃ |
| Boiling Point | 506.5±50.0℃ |
| Density | 1.357g/mL |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Category | Pakati peApixaban (CAS: 503612-47-3) |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Yellow Powder | Yellow Powder |
| Melting Point | 165.0 ~ 170.0 ℃ | 167.0~170.0℃ |
| Kurasika paKuomesa | ≤0.50% | 0.3% |
| Kusachena Kwemunhu (Max.) | ≤0.50% | 0.3% |
| Zvose Zvisina Kuchena | ≤1.00% | 0.6% |
| Kuchena / Analysis Method | ≥99.0% (HPLC) | 99.4% |
| 1 H NMR Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| LC/MS | Zvinoenderana NeChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chacho chakaedzwa uye chinoenderana nezvakapihwa | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
3-Morpholino-1- (4-Nitrophenyl) -5,6-Dihydropyridin-2 (1H)-imwe (CAS: 503615-03-0) ndiyo yepakati pekugadzirwa kweApixaban (CAS: 503612-47-3) .
Apixaban rudzi rutsva rweoral Xa factor inhibitor yakabatanidzwa pamwe chete neBristol-Myers Squibb uye Pfizer.Zita rekutengesa ndiro Eratol, inova rudzi rutsva rwemuromo anticoagulant.Nekudzivisa yakakosha coagulation factor Xa, Apixaban inogona kudzivirira thrombin kugadzirwa uye thrombosis.
Musi waKubvumbi 26, 2007, Bristol-Myers Squibb akabatana maoko naPfizer kuzivisa kubatana mukugadzirwa kweapixaban yemuromo anticoagulant yeBristol-Myers Squibb seimwe nzira yakakwidziridzwa kune warfarin.Maererano nechibvumirano chekushandira pamwe, Pfizer ichabhadhara mari yekumberi yeUS $ 0.25 bhiriyoni kuBristol-Myers Squibb kuti itakure makumi matanhatu muzana emutengo wakakwana wekuvandudza anticoagulant Apixaban (ichaitwa kubva muna Ndira 1, 2007), ukuwo Bristol-Myers. Squibb ichabereka makumi mana muzana asara, nokudaro kuwana kodzero yekugadzira pamwe chete nekutengesa mushonga.
Muna Chivabvu 2011, Apixaban ndiye akatanga kubvumidza kudzivirirwa kwevenous thrombosis muvarwere vakura vanovhiyiwa kusarudzwa kwehudyu kana kutsiva mabvi munyika dze27 EU, Iceland neNorway.
Musi waNovember 20, 2012, European Commission yakabvumira Ererto (Apixaban) yekudzivirira sitiroko uye systemic embolism muvarwere vakuru vane non-valvular atrial fibrillation (NVAF) ine imwe kana yakawanda yengozi.Zvadaro, Canadian Food and Drug Administration, Japan, uye US FDA yakabvumira Ererto (Apixaban) yekudzivirira sitiroko uye systemic embolism muvarwere vakura vane non-valvular atrial fibrillation (NVAF) ine imwe kana yakawanda yengozi.
Musi waKubvumbi 12, 2013, iyo itsva anticoagulant drug Eloto (ELIQUIS) (apixaban) yakabatanidzwa neBristol-Myers Squibb uye Pfizer yakaziviswa zviri pamutemo kuti yakanyorwa muChina.Ererto inoveli oral factor Xa inhibitor yekudzivirira venous thromboembolism (VTE) muvarwere vakuru vari kusarudzwa hudyu kana kutsiva ibvi.Rondedzero yaro inopa yakachengeteka uye inoshanda sarudzo nyowani yekiriniki anticoagulation mushure mekuvhiyiwa kwemapfupa, uye inounza nhau dzakanaka kuvarwere veChinese vari kutsiva hudyu/mabvi.Zvidzidzo zvemakiriniki zvakasimbisa kuti zvichienzaniswa ne40mg enoxaparin kamwe chete pazuva, 2 nguva pazuva remuromo weEratol (Apixaban) 2.5mg inonyanya kushanda pakudzivirira venous thromboembolism mushure mekuvhiyiwa kwehudyu kana mabvi, uye haiwedzere ngozi yekubuda ropa.
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