5-Amino-3-(Trifluoromethyl)picolinonitrile CAS 573762-62-6 Apalutamide Intermediate Purity>98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira 5-Amino-3-(Trifluoromethyl)picolinonitrile (CAS: 573762-62-6) ine mhando yepamusoro, yepakati yeApalutamide (CAS: 956104-40-8).Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Apalutamide Intermediates,Please contact: alvin@ruifuchem.com
| Chemical Name | 5-Amino-3-(Trifluoromethyl)picolinonitrile |
| Mashoko anoreva zvakafanana | 5-Amino-3-(Trifluoromethyl)pyridine-2-Carbonitrile;5-Amino-3-(Trifluoromethyl)2-Cyanopyridine;5-Amino-2-Cyano-3-(Trifluoromethyl)pyridine;Apalutamide Kusachena 10 |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 573762-62-6 |
| Molecular Formula | C7H4F3N3 |
| Molecular Weight | 187.12 g/mol |
| Density | 1.45±0.10 g/cm3 |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Hazard Kirasi | 6.1 |
| Packing Group | Ⅲ |
| Category | Pakati peApalutamide (CAS: 956104-40-8) |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Yero Yero kusvika Yero Yakasimba | Zvinoenderana |
| Mvura naKarl Fischer | <0.50% | 0.35% |
| Kuchena / Analysis Method | >98.0% (HPLC) | 99.03% |
| Infrared Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| 1H NMR Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chakaedzwa uye chinoenderana nezvakapihwa | |
| Application | Pakati peApalutamide (CAS: 956104-40-8) | |
Package:Fluorinated Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta muimba inotonhorera, yakaoma uye ine mhepo yakanaka kure nezvinhu zvisingaenderani.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
5-Amino-3- (Trifluoromethyl) picolinonitrile (CAS: 573762-62-6), inonzi pyridine heterocyclic organic compound, inogona kushandiswa semishonga yepakati.5-Amino-3- (Trifluoromethyl) picolinonitrile iri pakati peApalutamide (CAS: 956104-40-8).Apalutamide ndeyechipiri-chizvarwa antiandrogen inoshandiswa mukurapa kenza yeprostate.Iyo inopikisa ane simba ye androgen receptor ine IC50 kukosha kwe16 nM.Inosunga androgen receptors, nekudaro ichidzivirira nyukireya translocation, DNA kusunga uye transcriptional activation.Apalutamide ine kurapa kwekushandisa mune isiri-metastatic, castration-inodzivirira kenza yeprostate.
Apalutamide inoshandiswa kurapa mamwe marudzi eiyo castration-resistant cancer yeprostate kana kenza yeprostate isina kupararira kune dzimwe nhengo dzemuviri, asi isina kubatsirwa nemamwe marapirwo ekurapa.Apalutamide iri mukirasi yemishonga inonzi androgen receptor inhibitors.Inoshanda nekuvhara mhedzisiro ye androgen kumisa kukura uye kupararira kwekenza maseru.Musi waGunyana 17, 2019, iyo Chikafu neDrug Administration yakabvumidza Apalutamide (ERLEADA, Janssen Biotech, Inc) yevarwere vane metastatic castration-sensitive cancer yeprostate (mCSPC).Apalutamide yakatanga kubvumidzwa muna 2018 kune varwere vane-non-metastatic castration-resistant cancer prostate.
