TMC207 CAS 843663-66-1 Kuchena > 99.5% (HPLC)
TMC207 Inoenderana Nepakati:
TMC207 CAS 843663-66-1
3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2
3-Benzyl-6-Bromo-2-Methoxyquinoline CAS 654655-69-3
| Chemical Name | TMC207 |
| Mashoko anoreva zvakafanana | TMC-207, R207910;Sirturo;(αS,βR) -6-Bromo-α--[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1-(6-Bromo-2-methoxyquinolin-3-yl)-4-dimethylamino-1-phenyl-2-(1-naphthyl) 2-butanol |
| Nhamba yeCAS | 843663-66-1 |
| Nhamba yeCAT | RF2336 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C32H31BrN2O2 |
| Molecular Weight | 555.516 |
| Melting Point | 104℃ |
| Density | 1.322±0.06 g/cm3 |
| Sensitive | Hygroscopic.Chiedza Sensitive, Mhepo Inonzwa |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | White kana Off-White Powder |
| Kuchena / Analysis Method | >99.5% (HPLC) |
| Kurasika paKuomesa | <0.50% |
| Residue paIgnition | <0.20% |
| Chero Kusachena Kwemunhu | <0.10% |
| Isomer | <0.10% |
| Zvose Zvisina Kuchena | <0.50% |
| Heavy Metals (as Pb) | <20ppm |
| Arsenic (As) | <2.0ppm |
| Infrared Spectrum | Inopindirana neChimiro |
| Proton NMR Spectrum | Inopindirana neChimiro |
| Test Standard | Enterprise Standard |
| Usage | API |
Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro
Kutenga sei?Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Inonyanya kutumirwa kuNorth America, India, Russia, Korea, Japan, uye Europe, nezvimwe.
HunhuSimbiso?Kuvimbika kuvimbiswa kwehutano, kutonga kwakasimba.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, negungwa.
Custom Synthesis?Inogona kupa tsika synthesis masevhisi.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
(CAS: 843663-66-1), (inozivikanwa se TMC207 uye R207910), inotengeswa pasi pezita rekutengeserana rinonzi Sirturo, inoveli diarylquinoline antimycobacterial drug inobata tuberculosis nekudzivisa basa reM. tuberculosis ATP synthase proton pump.Iyo ATP synthesis ye mycobacteria inoshandisa antibacterial uye bactericidal mhedzisiro.Clinically inoshandiswa kurapa vanhu vakuru multidrug-resistant tuberculosis (MDR-PTB).TMC207 ine utachiona hwakafanana hwekurwisa M. tuberculosis twumhando uye twusingarambiki, uye inewo kunaka kwekuuraya utachiona pamabhakitiriya akarara.Muna Zvita 2012, US FDA yakabvumidza TMC207 sechikamu chemusanganiswa wekurapa kwechirwere cherurindi chisingarambiri zvinodhaka (MDRTB).TMC207 ndiwo mushonga wekutanga kubvumirwa MDR-TB uye ndiyo mvumo yekutanga kubva kuchikwata chitsva chemishonga yekurwisa tibhii mumakore makumi mana apfuura.Nekuda kwekunyanya kudiwa kwekurapa MDR-TB, FDA yakapa TMC207 mvumo yekukurumidza zvichibva pamhedzisiro yeChikamu chechipiri, ichipa varwere mukana wekuwana mushonga apo zvimwe zvidzidzo zvekiriniki zvichiitwa.TMC207 idiarylquinoline yakawanikwa kubva muchirongwa chepamusoro-soro, chekuongorora-sero-sero neMycobacterium smegmatis yakashandiswa seyakatsiva M. tuberculosis.TMC207 ndeye imwe enantiomer yekutanga yekutarisa hit.TMC207 ine simba uye inosarudza kurwisa mycobacteria, uye inoshanda kurwisa zvese zviri zviviri zvinodhaka uye zvisingaite mushonga M. tuberculosis.Nzira yekuita kweTMC207 yakasiyana pakati pemishonga inorwisa TB uye inosanganisira kuvharidzirwa kwemycobacterial ATP synthase;haisi kushanda inopesana nevanhu ATP synthase.TMC207 ine in vivo chiitiko mune akawanda preclinical modhi yehutachiona hweTB, yega uye yakabatana nemamwe anti-TB agent, uye ine hutachiona hwehutachiona mumhando dzakatangwa dzehutachiona hweTB.TMC207 inogadzirwa mumatanho mashanu kubva ku3-Phenylpropionic Acid uye para-Bromoaniline.Kutevera kuumbwa kweamide, kurapwa nePOCl3 uye DMF pasi peVilsmeier-Hack mamiriro akapa 2-Chloroquinoline chigadzirwa.Kurapa nesodium methoxide, kuchiteverwa nekugadzirisa ne3-(Dimethylamino) -1-(naphthalen-1-yl)propan-1-one, uye kupatsanurwa kwemaisomer kwakapa TMC207.
