Crizotinib Yepakati CAS 877399-00-3 Kuchena ≥98.0% (HPLC) ee ≥99.0%
Shanghai Ruifu Chemical Co., Ltd ndiyo inotungamira kugadzira (R) -5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00 -3) nehupamhi hwepamusoro, pakati peCrizotinib (CAS: 877399-52-5).Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Crizotinib Yepakati,Please contact: alvin@ruifuchem.com
| Chemical Name | (R) -5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine |
| Mashoko anoreva zvakafanana | Crizotinib Intermediate;Crizotinib Bromide Kusachena;5-Bromo-3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]-2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amine |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 877399-00-3 |
| Molecular Formula | C13H10BrCl2FN2O |
| Molecular Weight | 380.04 g/mol |
| Melting Point | 108.0 kusvika 113.0 ℃ |
| Density | 1.643 |
| COA & MSDS | Available |
| Muenzaniso | Available |
| Origin | Shanghai, China |
| Category | Pakati peCrizotinib (CAS: 877399-52-5) |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Yero Yero kune Yero Hupfu kusvika kuCrystal | Zvinoenderana |
| Melting Point | 108.0 kusvika 113.0 ℃ | Zvinoenderana |
| Purity (HPLC Area) | ≥98.0% | 99.1% |
| Enantiomeric Yakawandisa (EE) | ≥99.0% | 99.5% |
| Infrared Spectrum | Inopindirana neChimiro | Zvinoenderana |
| 1 H NMR Spectrum | Inopindirana neChimiro | Zvinoenderana |
| Mhedziso | Ichi chigadzirwa chakaedzwa uye chinoenderana nezvakatemwa | |
| Sherufu Hupenyu | 2 Makore kana Akachengetwa Zvakanaka | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
(R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl) ethoxy]pyridin-2-Amine (CAS: 877399-00-3) inoshandiswa sepakati peCrizotinib (CAS: 877399-52-5).
Crizotinib zvirokwazvo mushonga unopesana negomarara uchive alk (anaplastic lymphoma kinase) uye ros1 (c-ros oncogene 1) inhibitor, yakatenderwa kurapwa kweimwe isiri diki cell lung carcinoma (NSCLC) muUSA nedzimwe nyika, uye iri kuita zvidzidzo zvakawanda kuyedza kuchengetedzeka kwayo uye kushanda kwayo muanaplastic hombe cell lymphoma, neuroblastoma, uye mamwe mamota akasimba akasimba muvakuru nevana.
Crizotinib imishonga yakanangwa yekurapa isiri-diki yekenza yemapapu yakagadziridzwa naPfizer, USA, secorri muganho uye epoch-inogadzira mushonga mumunda wekunangwa kurapa cancer yemapapu.Yakatenderwa kushambadzira muUnited States muna Nyamavhuvhu 2011 uye yakanyorwa mumirayiridzo yekurapa kenza yemapapu epasi rese mukupera kwegore semushonga wekutanga wevarwere vane ALK-positive.Co-approved neCrizotinib ndiyo yekutanga genetic diagnosis nzira yekushandisa fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, iyi ndiyo nzira inoshandiswa parizvino mumakiriniki epasi rose kuedza kuona EML4-ALK fusion genes muNSCLC.Muedzo uyu uchabatsira kuona varwere vanogona kubatsirwa neCrizotinib kurapwa.
Crizotinib inosarudza tyrosine kinase receptor inhibitor inoshandiswa mukurapa kwezviitiko zvakasarudzwa zvekenza yemapapu isiri-diki yemapapu.Iyo iviri ATP inokwikwidza inhibitor ye tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) uye ALK (cellular IC50 = 20 nM), zvose zviri zviviri zvakakosha zvinangwa zvekenza kenza.Apo Crizotinib yakaedzwa kusarudzwa kunopesana nemamwe kinases yakawanikwa iine enzyme IC50 mukati me100-fold multiples ye c-MET ye13 ye120 kinases yakaedzwa.Mune cellular assays, Crizotinib yakawanikwa inhibit RON (recepteur d'origine nantais) kinase ine 10-fold selectivity window pamusoro peC-MET.Pamwe chete, mumiririri uyu anodzivirira tumor cell kukura.XALKORI®(Crizotinib) mushonga wemishonga unoshandiswa kurapa vanhu vasina diki-diki kenza yemapapu (NSCLC) yapararira kune dzimwe nhengo dzemuviri uye inokonzerwa nekukanganisika mune chero gene rinonzi ALK (anaplastic lymphoma kinase) kana gene rinonzi ROS1.Hazvizivikanwe kana XALKORI yakachengeteka uye inoshanda muvana.
