1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 Kuchena ≥98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira 1-Boc-4-(4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) ine mhando yepamusoro, yepakati yeCrizotinib (CAS: 877399- 52-5).Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Chemical Name | 1-Boc-4-(4-Bromopyrazol-1-yl)piperidine |
| Mashoko anoreva zvakafanana | Crizotinib-D;tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylic Acid tert-Butyl Ester;1-tert-Butoxycarbonyl-4-(4-Bromopyrazol-1-yl)piperidine;1-(4-Boc-Piperidino) -4-Bromopyrazole;1-Boc-4-(4-Bromo-1-Pyrazolyl)piperidine;4-Bromo-1-(N-Boc-Piperidin-4-yl)-1H-Pyrazole;tert-butyl 4-(4-Bromo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;1-(4-Boc-1-Piperidinyl) -4-Bromopyrazole;Crizotinib Kusachena 4 |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 877399-50-3 |
| Molecular Formula | C13H20BrN3O2 |
| Molecular Weight | 330.23 g/mol |
| Melting Point | 77.0 kusvika 81.0 ℃ |
| Density | 1.43 |
| Solubility | Soluble muMethanol |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Category | Pakati peCrizotinib (CAS: 877399-52-5) |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | White Solid | White Solid |
| Melting Point | 77.0 kusvika 81.0 ℃ | Zvinoenderana |
| Mvura naKarl Fischer | <0.50% | 0.11% |
| Kuchena / Analysis Method | ≥98.0% (HPLC) | 99.3% |
| 1H NMR Spectrum | Inopindirana neChimiro | Zvinoenderana |
| Misa | Inopindirana neChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chacho chakaedzwa uye chinoenderana nezvakapihwa | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Hazard Symbols Xn - Zvinokuvadza
Risk Codes 22 - Zvinokuvadza kana ikamedzwa
1-Boc-4- (4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) inoshandiswa sepakati peCrizotinib (CAS: 877399-52-5).Crizotinib (zita rekutengesa Xalkori,) mushonga unorwisa cancer unoshanda seALK (anaplastic lymphoma kinase) uye ROS1 (c-ros oncogene 1) inhibitor, yakatenderwa kurapwa kweimwe isiri diki cell lung carcinoma (NSCLC) muUS. uye nedzimwe nyika, uye iri kuita miedzo yekiriniki yekuyedza kuchengetedzeka uye kushanda kwayo inanaplastic hombe cell lymphoma, neuroblastoma, uye mamwe mamota akasimba akasimba muvakuru nevana.
Muna Nyamavhuvhu 2011, iyo United States FDA yakabvumidza Crizotinib (PF- 02341066) yekurapa anaplastic lymphoma kinase (ALK) yakarongazve isiri-diki-cell cancer yemapapu (NSCLC).Crizotinib ine mbiri ATP inokwikwidza inhibitor ye tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) uye ALK (cellular IC50 = 20 nM), zvose zviri zviviri zvakakosha zvinangwa zvekemotherapy kenza.Apo Crizotinib yakaedzwa kusarudzwa kunopesana nemamwe kinases yakawanikwa iine enzyme IC50 mukati me100-fold multiples ye c-MET ye13 ye120 kinases yakaedzwa.Mune cellular assays, Crizotinib yakawanikwa inhibit RON (recepteur d'origine nantais) kinase ine 10-fold selectivity window pamusoro peC-MET.
