1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole CAS 877399-73-0 Kuchena ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira 1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) ine mhando yepamusoro, yepakati yeCrizotinib (CAS: 877399-52 -5).Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Chemical Name | 1-(1-Boc-4-Piperidinyl) -4-Iodopyrazole |
| Mashoko anoreva zvakafanana | 1-Boc-4-(4-Iodo-1H-Pyrazol-1-yl)piperidine;tert-Butyl 4-(4-Iodo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;tert-Butyl 4-(4-Iodopyrazolyl)piperidinecarboxylate;Crizotinib Kusachena 16 |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 877399-73-0 |
| Molecular Formula | C13H20IN3O2 |
| Molecular Weight | 377.22 g/mol |
| Melting Point | 97℃ |
| Density | 1.60±0.10 g/cm3 |
| Sensitive | Chiedza Sensitive |
| Storage Temp. | 2 ~ 8 ℃, Dzivirira Kubva Kuchiedza |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Category | Pakati peCrizotinib (CAS: 877399-52-5) |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Ichena kusvika kuChiedza Yero Yakasimba | White Solid |
| Kuchena / Analysis Method | ≥99.0% (HPLC) | 99.58% |
| Infrared Spectrum | Inopindirana neChimiro | Zvinoenderana |
| 1 H NMR Spectrum | Inopindirana neChimiro | Zvinoenderana |
| ESI+ | Conforms | Zvinoenderana |
| Mhedziso | Chigadzirwa chacho chakaedzwa uye chinoenderana nezvakapihwa | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) nehupamhi hwepamusoro, pakati peCrizotinib (CAS: 877399-52-5).Crizotinib imishonga yakanangwa yekurapa isiri-diki yekenza yemapapu yakagadziridzwa naPfizer, USA, secorri muganho uye epoch-inogadzira mushonga mumunda wekunangwa kurapa cancer yemapapu.Yakatenderwa kushambadzira muUnited States muna Nyamavhuvhu 2011 uye yakanyorwa mumirayiridzo yekurapa kenza yemapapu epasi rese mukupera kwegore semushonga wekutanga wevarwere vane ALK-positive.Co-approved neCrizotinib ndiyo yekutanga genetic diagnosis nzira yekushandisa fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, iyi ndiyo nzira inoshandiswa parizvino mumakiriniki epasi rose kuedza kuona EML4-ALK fusion genes muNSCLC.Muedzo uyu uchabatsira kuona varwere vanogona kubatsirwa neCrizotinib kurapwa.pamakore makumi maviri nemashanu, uyu ndiwo mushonga wekutanga kushandiswa mukurapa varwere vane kenza yepamusoro kana metastatic isiri diki cell lung cancer (NSCLC) iri anaplastic lymphoma kinase (ALK) -positive sekutemerwa neSFDA-approved assay.
Crizotinib (PF-02341066) Crizotinib ine simba c-Met uye ALK inhibitor, iyo IC50 tsika mu cell assay yaive 11 nM uye 24 nM, zvichiteerana.Iyo zvakare inhibitor ine simba yeROS1 ine kukosha kweKi isingasviki 0.025 nM.Crizotinib inogona kukonzera autophagy mumhando dzakasiyana dzekenza yemapapu maseru nekuvharisa iyo STAT3 nzira.
