CAS 945667-22-1 Kuchena >99.0% (HPLC) API Featured Image

Purogiramu inonzi CAS 945667-22-1 Purity >99.0% (HPLC)

Tsanangudzo Pfupi

CAS: 945667-22-1

Kuchena:> 99.0% (HPLC)

Kuonekwa: White Powder

API, High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com

Tumira email kwatiri

Product Detail

Product Tags

Tsanangudzo:

Ruifu Chemical Supply Related Intermediates
CAS 361442-04-8
CAS 945667-22-1
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(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Chemical Properties:

Mashoko anoreva zvakafanana	BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ]hexane-3-Carbonitrile Hydrate
Nhamba yeCAS	945667-22-1
Nhamba yeCAT	RF-PI1992
Stock Status	MuStock, Kugadzirwa Kunokwira Kusvika Matani
Molecular Formula	C18H25N3O2·H2O
Molecular Weight	333.43
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	White Powder
identification	A: IR B: HPLC Kuchengeta Nguva
Kuchena / Analysis Method	> 99.0% (HPLC, On Dried Basis)
Zvemumvura (KF)	5.3% ~7.3%
Residue paIgnition	<0.20%
Kusachena Kumwechete	<0.50%
Zvose Zvisina Kuchena	<1.00%
Heavy Metals	<10ppm
Arsenic (As)	<2ppm
Microbiology
Total Plate Count	<1000cfu/g
Yeast & Mold	<100cfu/g
E. Coli	Negative
S. Aureus	Negative
Salmonella	Negative
Sherufu Hupenyu	24 Mwedzi
Test Standard	Enterprise Standard
Usage	API;Inoshandiswa Kurapa Rudzi II Chirwere cheshuga

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro

Zvakanakira:

FAQ:

Application:

API (CAS: 945667-22-1) inosarudza uye inogadziriswa dipeptidyl peptidase-4 (DPP4) inhibitor inogona kushandiswa kugadzira kurapa kwechirwere cheshuga chechipiri.Iyo inosarudza uye inodzoreredzwa DPP4 inhibitor ine IC50 ye26 nM uye Ki ye1.3 nM.IC50 kukosha: 26 nM.Target: DPP4 in vitro: Iine inhibition inogara Ki ye1.3 nM yeDPP4 inhibition, iyo ine simba rakapetwa kagumi pane Sitagliptin (imwe mbiri DPP4 inhibitors) ine Ki ye13 uye 18 nM.Uye zvakare, Iyo inoratidza hukuru hwakanyanya hweDPP4 pane chero iyo DPP8 kana DPP9 enzymes (400- uye 75- fold, zvichiteerana).Iyo inoshanda metablite yayo ine kaviri ine simba shoma pane mubereki.Zvose (CAS: 945667-22-1) uye metabolite yayo inonyanya kusarudza (> 4000-fold) yekudzivirira DPP4 kana ichienzaniswa nehuwandu hwemamwe maprotease.(CAS: 945667-22-1) inoderedza kuderedzwa kweiyo incretin hormone glucagon-like peptide-1, nokudaro ichiwedzera zviito zvayo, uye inobatanidzwa nekuvandudzwa kwe-β-cell basa uye kudzvinyirira kweglucagon secretion.in vivo: Inoshanda zvikuru. pakutsvaga yakaratidza dhigirii-inotsamira ekuwedzera muglucose clearance muyero renji 0.13-1.3 mg/kg mune ob/ob mbeva maererano nekutonga.