Celecoxib CAS 169590-42-5 Assay 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri weCelecoxib (CAS: 169590-42-5) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Celecoxib,Please contact: alvin@ruifuchem.com
| Chemical Name | Celecoxib |
| Mashoko anoreva zvakafanana | Celebrex;Celebra;Celecox;Onsenal;Solexa;SC-58635;SC 58635;YM-177;4- [5-(4-Methylphenyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-yl]benzenesulfonamide;5-(4-Methylphenyl)-1-(4-Sulfamoylphenyl)-3-(Trifluoromethyl)pyrazole |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 169590-42-5 |
| Molecular Formula | C17H14F3N3O2S |
| Molecular Weight | 381.37 g/mol |
| Melting Point | 160.0 kusvika 165.0 ℃ |
| Density | 1.43±0.10 g/cm3 |
| Mvura Solubility | Insoluble muMvura |
| Solubility | Yakanyanya Soluble muMethanol;Soluble muEthanol |
| COA & MSDS | Available |
| Muenzaniso | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Ichena kana Inenge Yakachena Crystalline Powder | Zvinoenderana |
| Assay | 98.0~102.0% | 99.8% |
| Melting Point | 160.0 kusvika 165.0 ℃ | 162.2℃ |
| Mvura naKarl Fischer | <0.50% | 0.11% |
| Residue paIgnition | <0.20% | 0.05% |
| Masimbi anorema (Pb) | ≤20ppm | <10ppm |
| Celecoxib Inoenderana Musanganiswa A | <0.40% | <0.20% |
| Celecoxib Inoenderana Musanganiswa B | <0.10% | <0.10% |
| Kusachena Kusingataurwi Kwemunhu | <0.10% | <0.10% |
| Zvose zvisina kuchena | <0.50% | 0.20% |
| Infrared Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| 1H NMR Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chakaedzwa uye chinoenderana nezvakapihwa | |
Package:Fluorinated Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Celecoxib
C17H14F3N3O2S 381.4
4- [5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide;
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide [169590-42-5]
DEFINITION
Celecoxib ine NLT 98.0% uye NMT 102.0% yeC17H14F3N3O2S, yakaverengerwa pane anhydrous basis.
KUZIVA
• A. INFRARED BSORPTION <197>: [NOTE-Nzira <197A>, <197K>, kana <197M> pasi peInfrared Absorption inogona kushandiswa.]
[Cherechedza-Kana iyo spectra yakawanikwa ichiratidza mutsauko, nyungudutsa chinhu chiongororwe uye Reference Standard zvakaparadzana mu isopropyl doro, evaporate kusvika pakuoma, uye rekodha chimiro chitsva.]
• B. Nguva yekuchengeta yenhongonya huru yeSample solution inoenderana neiyo yeStandard solution, sezvakawanikwa muAssay.
ASSAY
• MAITIRO
Buffer: 2.7 g/L ye monobasic potassium phosphate yakagadziridzwa nephosphoric acid kusvika pH ye3.0 ± 0.2
Nharembozha chikamu: Methanol, acetonitrile, uye Buffer (3:1:6)
Diluent: Methanol nemvura (3:1)
Sistimu yakakodzera mhinduro: 0.5 mg/mL yeUSP
Celecoxib RS uye 2.4 µg/mL imwe neimwe yeUSP Celecoxib Inoenderana Compound A RS uye USP Celecoxib Inoenderana Musanganiswa B RS muDiluent.
Mhinduro yakajairwa: 0.5 mg/mL yeUSP Celecoxib RS muDiluent
Sample solution: 0.5 mg/mL yeCelecoxib muDiluent
Chromatographic system
(Ona Chromatography <621>, System Suitability.)
Modhi: LC
Detector: UV 215 nm
Column: 4.6-mm × 25-cm;5-µm kurongedza L11
Column tembiricha: 60 °
Kuyerera kweyero: 1.5 mL/min
Jekiseni saizi: 25 µL
Nguva yekumhanya: Inenge 1.5 nguva iyo celecoxib peak elution
Kukodzera kwehurongwa
Samples: Kukodzera sisitimu mhinduro uye Standard mhinduro
Kukodzera zvinodiwa
Resolution: NLT 1.8 pakati pe celecoxib inoenderana nekomboni A uye Celecoxib uye NLT 1.8 pakati peCelecoxib neCelecoxib ine hukama nekomboni B, System kukodzera mhinduro
Relative mwero kutsauka: NMT 0.73%, Standard mhinduro
Analysis
Samples: Yakajairwa mhinduro uye Sample mhinduro
Verengai muzana yeC17H14F3N3O2S muchikamu cheCelecoxib chakatorwa:
Mhedzisiro = (rU/rS) × (CS/CU) × 100
rU = peak mhinduro kubva kuSample solution
rS = mhinduro yepamusoro kubva kune Standard solution
CS = kusangana kweiyo Standard solution (mg/mL)
CU = kusangana kweSample solution (mg/mL)
Maitiro ekugamuchira: 98.0% ~ 102.0% pane anhydrous basis
KUSIRIRA
Inorganic Impurities
• METARI ZVIKURU: NMT 20 ppm
Diluent: Acetone nemvura (17:3)
Mushonga wakajairwa: Dilute 1.0 mL yeStandard Lead Solution, yakagadzirwa sekurairwa pasi peHeavy Metals <231>, Special Reagents, ine Diluent kusvika 20 mL.
Sample solution: Dissolve 0.50 g yeCelecoxib mu20mL yeDiluent.
Mhinduro isina chinhu: 20 mL yeDiluent
Analysis
Samples: Standard solution, Blank solution, uye Sample solution
Kumushonga wega wega, wedzera 2 mL yepH 3.5 Acetate Buffer yakagadzirwa sezvinorayirwa pasi peMasimbi Anorema <231>, Method I. Sanganisa, uye wedzera kune imwe neimwe mhinduro 1.2 mL ye thioacetamide-glycerin base TS.Sakanidza pakarepo, uye bvumira kumira kwemaminitsi maviri.Pfuura mhinduro kuburikidza nesefa ye 0.45-µm pore saizi.Enzanisa mavara pamasefa akawanikwa kubva kune imwe neimwe yemhinduro.
Maitiro ekugamuchira: Ruvara rwebrownish-dema renzvimbo rinobva kuSample solution haina kusimba kupfuura yenzvimbo inokonzerwa neStandard solution.Muedzo haugoneki kana iyo Standard solution isingaratidze ruvara rwebrownish kana ichienzaniswa neBlank solution.
• ZVINOSARA PAZVINOGISA <281>: NMT 0.2%, vachishandisa platinamu crucible
Organic Kusachena
• PROCEDUR
Buffer, Nharembozha chikamu, Diluent, Sistimu yakakodzera mhinduro, Sample solution, uye Chromatographic system: Enderera sekurairwa muAssay.
Yakajairwa mhinduro: 0.5 µg/mL yeUSP Celecoxib RS muDiluent
Kukodzera kwehurongwa
Samples: Kukodzera sisitimu mhinduro uye Standard mhinduro
Kukodzera zvinodiwa
Resolution: NLT 1.8 pakati peCelecoxib inoenderana nekamu A uye Celecoxib uye NLT 1.8 pakati peCelecoxib neCelecoxib ine hukama B, Sistimu yakakodzera mhinduro
Chiratidzo-ku-ruzha chiyero: NLT 20, Yakajairwa mhinduro
Analysis
Samples: Yakajairwa mhinduro uye Sample mhinduro
Verengai muzana yekusachena kwega kwega muchikamu cheCelecoxib chakatorwa:
Mhedzisiro = (rU/rS) × (CS/CU) × 100
rU = peak mhinduro yekusachena yega yega muSample solution
rS = peak mhinduro yecelecoxib muiyo Standard mhinduro
CS = kuunganidzwa kwe celecoxib muiyo Standard solution (mg/mL)
CU = kusangana kweCelecoxib muSample solution (mg/mL)
Maitiro ekugamuchira
Kusachena kwemunhu: Ona Tafura 1.
[Cherechedza-Rega chero nhongonya yetsvina isingasviki 0.05%.]
Tafura 1
| Zita | Relative Retention Time | Maitiro ekugamuchira NMT (%) |
| Celecoxib inoenderana nemubatanidzwa Aa | 0.9 | 0.4 |
| Celecoxib | 1.0 | - |
| Celecoxib inoenderana nemubatanidzwa Bb | 1.1 | 0.10 |
| Kusachena kusingataurwi kwemunhu | - | 0.10 |
| Zvose zvisina kuchena | - | 0.5 |
a 4--[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
b 4- [3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
ZVIYEDZO ZVAKANAKA
• KUTARISA MVURA, Nzira I <921>: NMT 0.5%, uchishandisa muenzaniso we400-mg
ZVIMWE ZVINODIWA
• PACKAGE AND STORAGE: Chengetedza mumidziyo yakaoma, yakachengetedzwa kubva kuchiedza uye mwando.Chengetedza pane tembiricha yekamuri
• USP REFERENCE ZVINHU <11>
USP Celecoxib RS
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
C17H14F3N3O2S 381.4
USP Celecoxib Related Compound A RS
4- [5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
C17H14F3N3O2S 381.4
USP Celecoxib Inoenderana Musanganiswa B RS
4- [3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
C17H14F3N3O2S 381.4
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
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| Hazard Symbols | Xn - Zvinokuvadza |
| Risk Codes | R20/21/22 - Inokuvadza nekufema, kubata neganda uye kana ikamedzwa. |
| R52 - Inokuvadza kune zvipenyu zvemumvura | |
| R61 - Inogona kukonzera kukuvadza kumwana asati aberekwa | |
| R60 - Inogona kukanganisa kubereka | |
| Tsanangudzo Yekuchengetedza | S22 - Usafeme guruva. |
| S24/25 - Dzivisa kusangana neganda nemeso. | |
| S28 - Mushure mekusangana neganda, geza nekukasira nesipo yakawanda. | |
| S37/39 - Pfeka magirovhosi akakodzera uye dziviriro yeziso / kumeso | |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | DB2944937 |
| HS Code | 2935900090 |
| Hazard Kirasi | IRRITANT |
Celecoxib neRofecoxib maviri ari kushandiswa parizvino COX-2 inhibitors.Yakabudirira kugadzirwa neGD Searle & Pfizer Co. (US,) yakaburitswa muna 1999, zita rekutengesa: Celebrex.Celecoxib is nonsteroidal, anti-inflammatory agent ine yakakosha analgesic uye inorwisa-kuzvimba mhedzisiro, ichikonzera yakaderera chiitiko chepamusoro chemudumbu maronda emudumbu uye mamwe matambudziko.Inoshandiswa mukiriniki kurapa acute uye isingaperi osteoarthritis uye rheumatoid arthritis, ine anti-inflammatory analgesic basa, kubvisa zviratidzo uye zviratidzo zveosteoarthritis uye rheumatoid arthritis.
Celecoxib (CAS: 169590-42-5), Yekuzorora uye manejimendi yeosteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, kurwadziwa kwakanyanya, primary dysmenorrhea uye yemuromo adjunct kune yakajairika kutarisira varwere. ane mhuri adenomatous polyposis.
Celecoxib (CAS: 169590-42-5) ine anti-inflammatory uye analgesic effect yeNSAIDs.Nekuda kwechimiro chayo chemakemikari, inogona kusanganiswa neCOX-2, inosarudza inhibiting COX-2.Boka rayo re phenyl rinosunga ne hydrophobic chiteshi che COX-2, uye hydrophilic sulfonamide yayo inoumba hydrogen chain ine 513 arginine uye 90 histidine mu COX-2 "side homwe."Iyo zvakare iri pedyo nekubatana nearginine munzvimbo yeCOX-2120 uye inobata basa mukudzivisa COX-2 kubva pakushandura arachidonic acid kuita prostaglandins iyo inokuvadza kumuviri wemunhu. -2, Celecoxib haigoni kupinda muCOX-1 molecule, kana kudzivisa kushanduka kwayo kwearachidonic acid mu prostaglandins. Nokudaro, ine zvakanaka anti-inflammatory uye analgesic effects, inodzivirira gastric mucosa, inodzivirira kubuda kweropa renal, inodzora platelet aggregation, uye inogadzirisa Gastric irritation matambudziko ezvinowanzoshandiswa NSAIDs.
Celecoxib (CAS: 169590-42-5) inoratidzwa pakurapa osteoarthritis uye rheumatoid arthritis.Kushandiswa kwaro kunopesana kune vanhu vane hypersensitivity kune sulfonamides kana dzimwe NSAIDs.Inofanira kushandiswa nekuchenjerera kune vanhu vane chirwere chechiropa.Kudyidzana kunoitika nemimwe mishonga inokonzera CYP2C9 (eg rifampin rifampin) kana kukwikwidzana nemesabolism neenzyme iyi (eg fluconazole, leflunomide).Maitiro akajairika akashata kune celecoxib akapfava kusvika pakati nepakati GI mhedzisiro senge dyspepsia, manyoka, uye kurwadziwa mudumbu.Yakakomba GI uye renal mhedzisiro yakaitika kashoma.
