Chloramphenicol CAS 56-75-7 Kuchena ≥99.0% (HPLC) Kuchena Kwepamusoro
Mugadziri Wekutengesa neKuchena Kwepamusoro uye Kugadzirwa Kwekutengesa
(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 716-61-0
(1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 2964-48-9
Chloramphenicol CAS 56-75-7
| Chemical Name | Chloramphenicol |
| Mashoko anoreva zvakafanana | D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl) -1,3-propanediol;2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide |
| Nhamba yeCAS | 56-75-7 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C11H12Cl2N2O5 |
| Molecular Weight | 323.13 |
| Melting Point | 149.0 kusvika 153.0 ℃ (lit.) |
| Sensitive | Chiedza Sensitive |
| Solubility | Yakanyanya Soluble muEthanol, Methanol, Acetone.Soluble muEther, Chloroform.Insoluble muBenzene.Inoita Insoluble muMvura |
| Shipping Condition | Yakatumirwa Pasi peAmbient Temperature |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Ichena kusvika kuChiedza Yellow Powder |
| Identification A | Infrared Absorption |
| Kuzivikanwa B | Iyo nguva yekuchengeta yepamusoro peak muchromatogram yeAssay kugadzirira inoenderana neiyo muchromatogram yeiyo Standard gadziriro, sezvakawanikwa muAssay. |
| Specific Optical Rotation | +17.0°~+20.0° |
| Melting Point | 149.0~153.0℃ |
| Crystallinity | Zvinoita Zvinodiwa |
| pH | 4.5~7.5 |
| Kusachena Kumwechete | ≤0.50% |
| Zvose Zvisina Kuchena | ≤1.00% |
| Heavy Metals | ≤20ppm |
| Arsenic | ≤1ppm |
| Kurasika paKuomesa | ≤0.50% (105 ℃, maawa matatu) |
| Residue paIgnition | ≤0.10% |
| Kuchena / Analysis Method | ≥99.0% (HPLC) |
| Test Standard | Enterprise Standard;JP;USP |
Package: Bhodhoro, Aluminium foil bag, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, unyoro.
Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
Chloramphenicol ine kwete pasi pe97.0 muzana uye kwete kupfuura 103.0 muzana yeC11H12Cl2N2O5.
Kurongedza uye kuchengetedza-Chengetedza mumidziyo yakaoma.
Labeling-Iko kwainoitirwa kushandiswa mukugadzira jekiseni kana mamwe mafomu emushonga asina mbereko, iyo label inotaura kuti haina mbereko kana kuti inofanirwa kuenderera mberi nekugadziriswa panguva yekugadzirwa kwejekiseni kana mamwe mafomu ekuyeresa.
USP Reference mwero <11>-
USP Chloramphenicol RS Dzvanya kuti uone Chimiro
USP Endotoxin RS
Identification-
A: Infrared Absorption <197K>.
B: Nguva yekuchengeta yepamusoro-soro muchromatogram yeAssay kugadzirira inoenderana neiyo mukromatogram yeStandard gadziriro, sezvakawanikwa muAssay.
Melting range <741>: pakati pe149 ne153.
Kutenderera chaiko <781S>: pakati pe +17.0 uye +20.0.
Muedzo mhinduro: 50 mg, isina kuomeswa, pamL, mudoro risina mvura.
Crystallinity <695>: inosangana nezvinodiwa.
Bacterial endotoxins 85-Apo Chloramphenicol inotarisirwa kushandiswa mukugadzira mafomu ekubaya jekiseni, ine isingadariki 0.2 USP Endotoxin Unit pamg yechloramphenicol.
Sterility 71- Kana iyo label inotaura kuti Chloramphenicol haina mbereko, inosangana nezvinodiwa kana ichiongororwa sekunangwa kweMembrane Filtration pasi peMuedzo weKusabereka kweChigadzirwa kuti Chiongororwe, kunze kwekushandisa 1 g yemuenzaniso wakasimba.
pH <791>: pakati pe 4.5 ne 7.5, mune aqueous suspension ine 25 mg per mL.
Chromatographic kuchena-Dyisa huwandu hwakayerwa nemazvo hweChloramphenicol mumethanol kuti uwane mhinduro ine 10 mg pa mL.Gadzirira mushonga weUSP Chloramphenicol RS mumethanol ine 10 mg per mL (Standard solution A).Dirusai zvikamu zveStandard solution A muhuwandu nemethanol kuti uwane Standard solution B ine 100 µg per mL uye Standard solution C ine 50 µg per mL.Isa zvakaparadzana 20-µL zvikamu zveyedzo mhinduro uye Standard mhinduro B uye C kune yakakodzera yakatetepa-layer chromatographic plate (ona Chromatography 621), yakaputirwa ne0.25-mm layer yechromatographic silica gel musanganiswa.Gadzira chromatogram mune inonyungudutsa system ine musanganiswa wechloroform, methanol, uye glacial acetic acid (79:14:7) kusvika iyo inonyungudutsa kumberi kwave kufamba kunosvika zvikamu zvitatu kubva muzvina zvehurefu hwendiro.Bvisa ndiro kubva mukamuri, mhepo yakaoma, uye ongorora pasi penguva pfupi-wavelength UV mwenje: chero nzvimbo kunze kweiyo huru nzvimbo yakawanikwa kubva muyedzo mhinduro haipfuure muhukuru kana kusimba kweiyo nzvimbo huru yakawanikwa kubva kuStandard solution B (1% ), uye huwandu hwetsvina inomiririrwa nechero makwapa kunze kwenzvimbo huru, zvichibva pakuenzanisa kusimba kwenzvimbo dzakadaro nekusimba kwenzvimbo huru dzakawanikwa kubva kuStandard solutions B neC, haipfuure 2% .
Kuongorora-
Nharembozha-Gadzirira musanganiswa wakakodzera wakasefa wemvura, methanol, uye glacial acetic acid (55:45:0.1).Ita zvigadziriso kana zvichidikanwa (ona System Suitability pasi peChromatography 621).
Kugadzirira kwakajairwa- Dissolve huremu hwakayerwa nemazvo eUSP Chloramphenicol RS muMobile phase, uye dilute zvine mutsindo, uye nhanho kana zvichidikanwa, neMobile phase kuti uwane mhinduro ine inoziikanwa concentration inosvika 80 µg per mL.Sefa chikamu chemhinduro iyi kuburikidza ne 0.5-µm kana yakatsetseka porosity sefa, uye shandisa iyo yakajeka sefa seStandard gadziriro.
Kugadzirira kweAssay- Kutamisa nezve 200 mg yeChloramphenicol, yakanyatsoyerwa, kune 100-mL volumetric flask, wedzera Nharembozha kuhuwandu, uye sanganisa.Chinja 4.0 mL yemhinduro inoguma ku100-mL volumetric flask, dilue neMobile phase kusvika kuvhoriyamu, uye sanganisa.Sefa chikamu chemhinduro iyi kuburikidza ne0.5-µm kana yakatsetseka porosity sefa, uye shandisa iyo yakajeka filtrate segadziriro yeAssay.
Chromatographic system (ona Chromatography <621>)-Iyo chromatograph yemvura inogadzirwa ne 280-nm detector uye 4.6-mm × 10-cm column ine 5-µm packing L1.Chiyero chekuyerera chinenge 1 mL paminiti.Chromatograph iyo Yakajairwa gadziriro, uye rekodha mhinduro dzepamusoro sekurairwa pasi peChirongwa: iyo mbiru inoshanda yakatemerwa kubva kune analyte peak haisi pasi pe1800 theoretical mahwendefa, iyo tailing factor haina kupfuura 2.0, uye chiyero chakajairwa kutsauka kwemajekiseni anodzokorora zvinopfuura 1.0%.
Maitiro--[chinyorwa-Shandisa nzvimbo dzepamusoro apo mhinduro dzepamusoro dzinoratidzwa.] Bayirai mavhoriyamu akaenzana (anenge 10 µL) eGwaro regadziriro negadziriro yeAssay mukromatograph, rekodha makromatogiramu, uye meya mhinduro dzenhongonya huru.Verenga huwandu, mu mg, hweC11H12Cl2N2O5 muchikamu cheChloramphenicol chakatorwa neformula:
2.5C(rU / rS)
umo C ndiyo inosanganisirwa, muµg per mL, yeUSP Chloramphenicol RS muStandard gadziriro, uye rU nerS ndiwo mhinduro dzepamusoro dzakawanikwa kubva mugadziriro yeAssay uye gadziriro yeMagariro, zvichiteerana.
Chloramphenicol
C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide [56-75-7]
Chloramphenicol ine kwete isingasviki 980 MG (potency) uye kwete kupfuura 1020 MG (potency) pamg, akaverengerwa pamusoro wakaomeswa hwaro.Simba reChloramphenicol rinoratidzwa sehuwandu (potency) yechloramphenicol (C11H12Cl2N2O5).
Tsanangudzo Chloramphenicol inoitika sechena kusvika kune yero jena, makristasi kana crystalline poda.
Inonyungudika zvakasununguka mumethanol uye mu ethanol (99.5), uye inonyungudika zvishoma mumvura.
Kuzivikanwa (1) Sarudza kunyura kwemuenzaniso wemhinduro yakawanikwa muAssay sekurairwa pasi peUltraviolet-inooneka Spectrophotometry <2.24>, uye enzanisa iyo spectrum neReferensi Spectrum kana spectrum yemhinduro yeChloramphenicol RS yakagadzirirwa nenzira imwecheteyo. mhinduro yekuenzanisira: ese ari maviri anoratidza kusimba kwakafanana kwekunyura pamawavelengths akafanana.
(2) Sarudza iyo infrared absorption spectrum yeChloramphenicol sezvakarairwa mu potassium bromide disk nzira pasi peInfrared Spectrophotometry <2.25>, uye enzanisa spectrum neReferensi Spectrum kana spectrum yeChloramphenicol RS: zvose zvinoratidzira zvinoratidzira kusimba kwakafanana pakutorwa kwakafanana. wave number.
Optical rotation <2.49> [a]20D: +18.5~+21.5℃ (1.25 g, ethanol (99.5), 25 mL, 100 mm).
Melting point <2.60> 150~155℃
Kuchena (1) Heavy metals <1.07>-Ramba ne1.0 g yeChloramphenicol maererano neMethod 2, uye ita bvunzo.Gadzirira mhinduro yekutonga ne 2.5 mL yeStandard Lead Solution (kwete kupfuura 25 ppm).
(2) Arsenic <1.11> -Gadzirira mhinduro yekuedza ne 2.0 g yeChloramphenicol maererano neMethod 4, uye ita muedzo (kwete kupfuura 1 ppm).
(3) Zvinhu zvinoenderana-Dissolve 0.10 g yeChloramphenicol mu10 mL yemethanol, uye shandisa mhinduro iyi seyemuenzaniso mhinduro.Pipeti 1 mL yemhinduro yemuenzaniso, wedzera methanol kuti ugadzire 100 mL chaiyo, uye shandisa mhinduro iyi seyakajairwa mhinduro (1).Pipeti 10 mL yemushonga wakajairwa (1), wedzera methanol kugadzira 20 mL chaiyo, uye shandisa mhinduro iyi seyakajairwa mhinduro (2).Ita bvunzo nemhinduro idzi sekurairwa pasi peThin-layer Chromatography <2.03>.Spot 20 mL imwe neimwe yemhinduro yemuenzaniso uye yakajairwa mhinduro (1) uye (2) pandiro yesilica gel ine fluorescent chiratidzo chetete-layer chromatography, gadzira ndiro nemusanganiswa wechloroform, methanol uye acetic acid (100) ( 79:14:7) kusvika chinhambwe chingangoita masendimita gumi nemashanu, woomesa ndiro.Ongorora pasi pe ultraviolet mwenje (main wavelength: 254 nm): makwapa kunze kwenzvimbo huru uye nzvimbo pane yepakutanga yakawanikwa kubva mumuenzaniso mhinduro haina kusimba kupfuura nzvimbo yakawanikwa kubva kune yakajairwa mhinduro (1), uye iyo yakazara amunt. yeaya mavara kubva kumuenzaniso mhinduro haisi kupfuura 2.0%.
Kurasikirwa pakuomeswa <2.41> Kwete kupfuura 0.5% (1 g, 105℃, maawa matatu).
Zvisaririra pakubatidza <2.44> Kwete kupfuura 0.1%(1 g).
Muedzo Weresa nemazvo huwandu hweChloramphenicol neChloramphenicol RS, yakaenzana ne0.1 g (potency), nyungudusa imwe neimwe mu20 mL yemethanol, wowedzera mvura kuti iite zana chairo remL.Pombi 20 mL imwe neimwe yemhinduro idzi, wowedzera mvura kuita zana chairo remL.Pipet 10 mL imwe neimwe yemhinduro idzi, wedzera mvura kuti ugadzire 100 mL chaiyo, uye shandisa mhinduro idzi seyemuenzaniso mhinduro uye yakajairwa mhinduro.Sarudza kunyura, AT uye AS, pa 278 nm yemuenzaniso mhinduro uye yakajairwa mhinduro sezvakarairwa pasi peUltraviolet-inooneka Spectrophotometry <2.24>.
Nhamba [mg (potency)] yechloramphenicol (C11H12Cl2N2O5)
＝ MS × AT/AS × 1000
MS: Nhamba [mg (potency)] yeChloramphenicol RS
kutorwa
Midziyo uye kuchengetedza Containers-Tight midziyo.
Risk Codes R45 - Inogona kukonzera gomarara
R11 - Yakanyanya Kupisa
R39/23/24/25 -
R23/24/25 - Muchetura nekufema, kubata neganda uye kana kumedzwa.
Tsanangudzo Yekuchengetedza S53 - Dzivisa kubuda - wana mirairo yakakosha usati washandisa.
S45 - Kana pakaitika tsaona kana ukanzwa usinganzwe zvakanaka, tsvaga zano rekurapa nekukasira (ratidza chinyorwa pese pazvinogoneka.)
S16 - Chengetedza kure nenzvimbo dzekudzima.
S36/37 - Pfeka zvipfeko zvekudzivirira zvakakodzera uye magurovhosi.
UN IDs 2811
WGK Germany 3
RTECS AB6825000
FLUKA BRAND F CODES 3-10
TSCA Hongu
HS Code 2941400000
Hazard Kirasi 3
Toxicity LD50 yemuromo mugonzo: 2500mg/kg
P501: Rasa zviri mukati / mudziyo kune inotenderwa marara chirimwa.
P260: Usafeme guruva/ utsi/ gasi/ mhute/ mhute/ pfapfaidzo.
P270: Usadye, kunwa kana kuputa kana uchishandisa chigadzirwa ichi.
P202: Usabate kusvikira zvese zvekuchengetedza zvaverengwa nekunzwisiswa.
P201: Tora mirairo yakakosha usati washandisa.
P264: Geza ganda zvakakwana mushure mekubata.
P280: Pfeka magirovhosi ekudzivirira / zvipfeko zvinodzivirira / kudzivirira maziso / kudzivirira kumeso.
P308 + P313: KANA akafumurwa kana kunetseka: Wana zano rekurapa/ kutariswa.
P405: Chitoro chakakiyiwa.
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mutengesi weChloramphenicol (CAS: 56-75-7) ine mhando yepamusoro.Chloramphenicol is wide-spectrum antibacterial antibiotic, inova sarudzo yekutanga yekurapa typhoid uye paratyphoid, chechipiri, inoshandiswa pakurapa kwezvirwere zvakasiyana-siyana zvinotapukira zvinokonzerwa nehutachiona hwehutachiona.Nekuda kwekukanganisa kwakanyanya kwakashata iko zvino kushandiswa kushoma uye kushoma.Iyo antibacterial spectrum, basa uye kushandiswa kwakafanana nekloramphenicol yekurapa kweSalmonella Typhi, Shigella, Escherichia coli, furuwenza, Brucella, pneumonia zvirwere zvinokonzerwa necocci nemamwe maanti-infective zvinodhaka.Chloramphenicol inonyanya kushandiswa kurapa urinary tract infection, Pneumonia, abdominal infection uye septicemia inokonzerwa nemabhakitiriya anonzwisa tsitsi, pamwe chete nemadonhwe ekunze uye madonhwe enzeve.
UN3249 Mishonga, yakasimba, ine chepfu, nos, Chikamu cheNjodzi: 6.1;Labels: 6.1-Chepfu zvinhu.UN2811 Toxic solids, organic, nos, Hazard Class: 6.1;Labels: 6.1- Chepfu zvinhu, Technical Name Inodiwa.
