β-Cyclodextrin (β-CD) CAS 7585-39-9 Assay 98.0% ~ 102.0% Factory
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira β-Cyclodextrin (β-CD) (CAS: 7585-39-9) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga β-Cyclodextrin,Please contact: alvin@ruifuchem.com
| Chemical Name | β-Cyclodextrin |
| Mashoko anoreva zvakafanana | β-CD;BCD;beta-Cyclodextrin;Cycloheptaamylose;Schardinger β-Dextrin;Caraway;Cyclomaltoheptaose;Betadex |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 7585-39-9 |
| Molecular Formula | C42H70O35 |
| Molecular Weight | 1,134.99 |
| Melting Point | 290.0~300.0℃(Zvita.) (lit.) |
| Density | 1.44 g/cm3 pa20℃ |
| Mvura Solubility | Soluble mumvura |
| Solubility mumvura inopisa | Kuda Kujeka |
| Kugadzikana | Yakagadzikana.Haienderane ne yakasimba Oxidizing Agents. |
| COA & MSDS | Available |
| Yemahara Muenzaniso | Available |
| Brand | Ruifu Chemical |
| Items | Zvinotsanangurwa | Results |
| Chitarisiko | White Crystalline Powder, Haina hwema, Inonaka zvishoma | Conforms |
| Identification | Muedzo weIodine: Yellow-Brown Precipitate | Conforms |
| Assay | 98.0%~102.0% | 99.9% |
| Kujeka uye Rudzi rweKugadzirisa | Yakajeka uye isina Ruvara Solution | Conforms |
| pH ye1% Aqueous Solution | 5.0~8.0 | 6.1 |
| Kuderedza Shuga | ≤0.20% | <0.20% |
| Chiedza-chinobvisa tsvina | ≤0.10 (230nm-350nm)≤0.05 (230nm-350nm) | Conforms |
| Kutenderera kwakananga [a]20/D | +159.0 ° kusvika +164.0 ° | +161.5° |
| Kurasika paKuomesa | ≤14.0% | 11.5% |
| Residue paIgnition | ≤0.10% | ≤0.05% |
| Heavy Metals | ≤10ppm | <5ppm |
| Chloride | ≤0.018% | <0.018% |
| Total Aerobic Microbial Count | ≤1000cfu/g | Conforms |
| Total Molds & Yeasts Count | ≤100cfu/g | Conforms |
| Salmonella | Ndisipo/10 g | Conforms |
| E. Coli | Ndisipo/1 g | Conforms |
| Alpha Cyclodextrin | ≤0.25% | Hapana |
| Gamma Cyclodextrin | ≤0.25% | Hapana |
| Zvimwe Zvinoenderana Nezvinhu | ≤0.50% | Hapana |
| Infrared Spectrum | Inopindirana neChimiro | Conforms |
| Mhedziso | Chigadzirwa chakaedzwa uye chinoenderana neStandard USP35 | |
Package:Fluorinated Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta muimba inotonhorera, yakaoma uye ine mhepo yakanaka kure nezvinhu zvisingaenderani.Dzivirira kubva kuchiedza uye unyoro.Haienderani neoxidizing agents.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenderera chaiko
Tora chigadzirwa ichi, uiremedze chaizvo, wedzera mvura kuti inyunguduke uye quantitatively diluted mune mhinduro ine anenge 10 MG per 1 ml, uye sarudza maererano nemutemo (General mutemo 0621), chaiyo kutenderera kwaiva 159 ° kusvika 164 °.
Differential diagnosis
Tora inenge 0.2g yechigadzirwa ichi, wobva wawedzera 2ml yeIodine test solution, woipisa mubhavhu remvura kuti inyunguduse, woita kuti itonhore kuti ibudise mvura yero-brown.
Mune chromatogram yakanyorwa pasi pechinhu chekutsunga chemukati, nguva yekuchengeta yepamusoro-soro yemhinduro yebvunzo inofanirwa kuenderana nenguva yekuchengeta iyo yepamusoro peak yekutonga mhinduro.6
Iyo infrared absorption spectrum yechigadzirwa ichi inofanirwa kuenderana neiyo yereferensi chigadzirwa (General mutemo 0402).
Kubviswa kwetsvina
Tora chigadzirwa ichi chinenge 1 g, kunyatsoyera kuyera, wedzera mvura 100ml kuti inyunguduke, maererano neUV-inooneka spectrophotometry (General mutemo 0401) kutsunga, kunyura muwavelength renji ye230 ~ 350nm haifanire kudarika 0.10, kunyura muwavelength renji. ye350 ~ 750nm haifanirwe kudarika 0.05.
pH
tora 0.20g yechigadzirwa ichi, wedzera 20ml yemvura kuti inyunguduke, wedzera 0.2ml ye saturated potassium chloride solution, uye sarudza maererano nemutemo (General rule 0631), pH kukosha kunofanira kuva 5.0 ~ 8.0.
Kujeka uye ruvara rwemhinduro
Tora chigadzirwa ichi 0. 50g, wedzera 50ml yemvura kuti iparadze, chengetedza maererano nemutemo (General mutemo 0901 uye mutemo mukuru 0902), mhinduro inofanira kuva yakajeka uye isina ruvara;Muchiitiko che turbidity, enzanisa neNo.
Chloride
Tora chigadzirwa ichi 0.39G, yakatariswa maererano nemutemo (General mutemo 0801), uye yakajairwa sodium chloride mhinduro 7.0ml haifanirwe kuve yakanyanya kuomeswa kupfuura iyo control solution (0.018%).
Kuderedza shuga
Tora chigadzirwa ichi 1.0 g, huremu chaihwo, wedzera mvura 25ml kuti inyunguduke, Wedzera alkaline copper tartrate test solution 40tnl, zvishoma nezvishoma bika kwemaminetsi matatu, isa pamhepo tembiricha husiku hwese, sefa ine 4 # yakatwasuka yakanyunguduka funnel, iyo mvura yakashambidzwa nemvura inodziya. kusvikira mushonga wekugeza usina kwazvakarerekera.Iyo filtrate uye yekuwachira mhinduro yakaraswa, ichipisa ne potassium permanganate titration solution (0 .0M ol/L) titration.Maererano nechigadzirwa chakaoma, kushandiswa kwe potassium permanganate titrant (0.02 Mol / l) paL g haifaniri kudarika 3.2ml (1.0%).
Cyclohexane
Tora inenge 0.2g yechigadzirwa ichi, kunyatsoyera kuyera, mubhodhoro repamusoro risina chinhu, wedzera mhinduro yemukati (tora chiyero chakanaka che dichlorethylene, wedzera 20% dimethyl sulfoxide solution kuti uite mhinduro ine inenge 0.04 mune imwe neimwe lm l, ( Yakagadzirira ) 10.0ml, semhinduro yekuedza; Imwe chaiyo inoyera cyclohexane, pamwe nemukati muyero wekugadzirisa kuita inenge 1 l/l ine cyclohexane 0.078mg yemhinduro, kuyera 10.0ml mubhodhoro repamusoro risina chinhu semhinduro yekutonga. Maererano nemuedzo we residual solvent determination (General mutemo 0861), iyo capillary column ine 100% dimethylpolysiloxane semvura yakamira inoshandiswa se chromatographic column; Tembiricha yekoramu i90 ℃; Tembiricha yekupinza i200 ℃; Tembiricha ye detector i250 ℃; iyo Headspace bhodhoro. tembiricha yekuenzanisa yaive 70 ℃ uye nguva yekuenzanisa yaive maminitsi makumi maviri.Mhinduro yekuyedza uye mhinduro yereferenzi inoteedzerwa mumusoro, iyo chromatogram inorekodhwa, uye nzvimbo yepamusoro inoverengerwa zvinoenderana neyemukati chiyero nzira.
Kurasikirwa pakuomeswa
Tora chigadzirwa ichi, chakaoma kuti chirambe chichirema pa105 ℃, kurasikirwa nehuremu hakufaniri kudarika 14.0% (General mutemo 0831).
Ignition yasara
Iyo 1.0 g yechigadzirwa ichi ichatorwa kuti iongororwe maererano nemutemo (General mutemo 0841), uye zvakasara zvakasara hazvingapfuuri.
Heavy metals
Zvakasara zvakasara pasi pechinhu chekutora zvakasara zvemoto hazvifaniri kuva nezvikamu zvinopfuura gumi pamamiriyoni eheavy metal kana zvichiongororwa nemutemo (General Principles 0821, Law II).
Microbial muganhu
Ichi chigadzirwa chichatorwa nekuongororwa maererano nemutemo (General Principles 1105 uye 1106).Huwandu hwehuwandu hwehutachiona hweaerobic pa lg yechigadzirwa chebvunzo haifanire kudarika 100cfu, iyo yakazara nhamba yezviumbwa uye mbiriso haifaniri kudarika 100cfu, E. Coli haifanirwe kuonekwa.
Kutsunga kwemukati
Yakayerwa nepamusoro pekuita liquid chromatography (General 0512).
Chromatographic mamiriro uye system suitability test a Gumi nesere alkyl silane-bonded silica gel yakashandiswa sekuzadza;Mvura-methanol (85: 15) yakashandiswa sechikamu chekufambisa;Uye kuyerwa kwakaitwa nekusiyanisa refractive index detector.Iyo theoretical plate nhamba haisi pasi pe1500 yakaverengerwa se betal cyclodextrin peak.
nzira yekutsunga: tora inenge 50mg yechigadzirwa ichi, uiyera nemazvo, uise mu 10ml yekuyeresa flask, wedzera huwandu hwakakodzera hwemvura kuti inyunguduke uye inyungurudze pachiyero, zunza zvakanaka, uye ishandise semhinduro yekuedza, 10 / xl. yakabaiwa muchromatograph yemvura nenzira kwayo, uye chromatogram yakarekodhwa.Imwe 50mg yezvinyorwa zvebetaloc cyclodextrin yakayerwa nemazvo, uye nzira imwechete yakashandiswa pakusarudza.Zvinoenderana nekunze chiyero nzira yekuverenga nzvimbo yepamusoro, kureva.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Hazard Symbols Xi - Irritant
Risk Codes
R36/37/38 - Kushungurudza maziso, kufema system uye ganda.
R20 - Inokuvadza nekufema
Tsanangudzo Yekuchengetedza
S26 - Kana wasangana nemaziso, simbura nekukasira nemvura yakawanda uye tsvaga mazano ekurapwa.
S36 - Pfeka zvipfeko zvinodzivirira zvakakodzera.
S24/25 - Dzivisa kusangana neganda nemeso.
WGK Germany 2
RTECS GU2293000
TSCA Hongu
HS Code 3505100000
β-Cyclodextrin (β-CD) (CAS: 7585-39-9), Cyclodextrins inoreva mhuri yemishonga inosanganisira shuga molecules yakasungwa pamwe chete mumhete (cyclic oligosaccharides).Inogadzirwa kubva kune starch kuburikidza nekushandura enzymatic.Beta-cyclodextrin ndiyo 7-membered sugar ring molecular form ye cyclodextrin.Cyclodextrin ine maitiro akasiyana-siyana.Muindasitiri yemishonga, inogona kushandiswa seanoomesesa ekuwedzera kunyungudika kwemushonga usinganyungudika pamwe nekuwedzera bioavailability uye kugadzikana.Zvinogonawo kuderedza kushatirwa kwemishonga yemudumbu, uye kudzivirira kusangana kwezvinodhaka-zvinodhaka uye zvinodhaka-zvinobatsira.Inogona zvakare kushandiswa mukudya, mishonga, kuendesa zvinodhaka, uye maindasitiri emakemikari, pamwe nekurima uye engineering yezvakatipoteredza.
β-Cyclodextrin inoshandiswa sechinhu chinoomesera mukuunza zvinodhaka nekuti inoumba mubatanidzwa une mamorekuru emushonga.Iyo yakaoma ye cyclodextrin inowedzera kunyungudika kwemvura, chiyero chekunyungudika uye bioavailability yemishonga isina kunyungudika nemvura, iyo inobatsira pakuunzwa kwemumiririri wekurapa kune biological system.
Cyclodextrins inoitika sechena, isinganhuhwi, yakanaka crystalline poda, ine kakunaka kutapira.Zvimwe zvinokonzerwa ne cyclodextrin zvinoitika seamorphous powders.Beta-Cyclodextrin ndiyo yakanyanya kuwanda uye yakachipa cyclic oligosaccharide inoumba inclusion complexes ine akati wandei emishonga mamorekuru.Chishandiso chayo chikuru chiri muhwendefa uye capsule magadzirirwo.
Cyclodextrins i'bucketlike' kana 'conelike' toroid molecules, ine dhizaini yakaoma uye yepakati mhango, saizi yacho inosiyana zvichienderana nerudzi rwe cyclodextrin.Iyo yemukati yemukati yegomba ndeye hydrophobic uye kunze kweiyo torus ndeye hydrophilic;izvi zvinokonzerwa nekurongeka kwemapoka ehydroxyl mukati memorekuru.Urongwa uhwu hunobvumira iyo cyclodextrin kuti igare muenzi mamorekuru mukati megomba, ichigadzira inclusion complex.
Cyclodextrins inogona kushandiswa kuumba inclusion complexes ane akasiyana siyana emishonga mamorekuru, zvichikonzera kunyanya kuvandudzwa kwekuparara uye bioavailability nekuda kwekuwedzera kunyungudika uye kuvandudzwa kwemakemikari uye kugadzikana kwemuviri.
Cyclodextrin inclusion complexes yakashandiswawo kuvhara kuravira kusingafadzi kwezvinhu zvinoshanda uye kushandura chinhu chemvura kuita chinhu chakasimba.
β-Cyclodextrin ndiyo inonyanya kushandiswa cyclodextrin, kunyange zvazvo iri shoma shoma.Ndiyo cyclodextrin inodhura zvishoma;inowanikwa mune zvekutengeserana kubva kune akati wandei;uye inokwanisa kuumba inclusion complexes ine nhamba yemamorekuru emushonga wemishonga.Zvisinei, β-Cyclodextrin inonzi nephrotoxic uye haifaniri kushandiswa mukugadzirwa kwevabereki.β-Cyclodextrin inonyanya kushandiswa muhwendefa uye capsule formulations.
Mukuumbwa kwehwendefa remuromo, β-Cyclodextrin inogona kushandiswa mune zvose zvakanyorova-granulation uye zvakananga-kudzvinyirira maitiro.Zvinhu zvemuviri zve β-Cyclodextrin zvinosiyana zvichienderana nemugadziri.Zvisinei, β-Cyclodextrin inenge iine hurombo hwekuyerera zvivakwa uye inoda lubricant, senge 0.1% w/w magnesium stearate, kana yakanyatso kudzvanywa.
Mukugadzirwa kwevabereki, cyclodextrins yakashandiswa kugadzira yakagadzikana uye inonyungudika gadziriro yemishonga ingadai yakave yakagadzirwa uchishandisa nonaqueous solvent.
Mukudonha kwemaziso, cyclodextrins inoumba mvura-soluble complexes ine lipophilic mishonga yakadai se corticosteroids.Ivo vakaratidzirwa kuwedzera kunyungudika kwemvura yemushonga;kuwedzera kunyura kwezvinodhaka muziso;kuvandudza kugadzikana kwemvura;uye kuderedza kushatirwa kwenzvimbo.
Cyclodextrins yakashandiswawo mukugadzira mhinduro, suppositories, uye cosmetics.
Cyclodextrins zviwanikwa zve starch uye zvinonyanya kushandiswa mumuromo uye parenteral mishonga yemishonga.Izvo zvinoshandiswawo mune topical uye ophthalmic formulations.
Cyclodextrins inoshandiswawo muzvizora uye zvigadzirwa zvechikafu, uye zvinowanzoonekwa sezvisina chepfu uye zvisingaite zvinhu.Zvisinei, kana ichishandiswa parenterally, β-Cyclodextrin haisi metabolized asi inounganidza muitsvo se-insoluble cholesterol complexes, zvichiita kuti nephrotoxicity yakaoma.
Cyclodextrin inoshandiswa nemuromo inogadziriswa ne microflora mukoloni, ichigadzira metabolites maltodextrin, maltose, uye glucose;aya pachawo anowedzerwa metabolized asati apedzisira aburitswa secarbon dioxide nemvura.Kunyange zvazvo chidzidzo chakabudiswa muna 1957 chakaratidza kuti cyclodextrins yaiitwa nemuromo yakanga ine chepfu, zvidzidzo zvekare zvehupfu hwemhuka mumakonzo nembwa zvakaratidza kuti izvi hazvisizvo, uye cyclodextrins yava kubvumirwa kushandiswa muzvigadzirwa zvekudya uye nemuromo inotungamirirwa nemishonga mune nhamba. yenyika.
Cyclodextrins haitsamwise ganda nemeso, kana pakufema.Iko hakuna zvakare humbowo hunoratidza kuti cyclodextrins ndeye mutagenic kana teratogenic.
β-Cyclodextrin
LD50 (mbeva, IP): 0.33 g/kg(16)
LD50 (mbeva, SC): 0.41 g/kg
LD50 (gonzo, IP): 0.36 g/kg
LD50 (gonzo, IV): 1.0 g/kg
LD50 (gonzo, nemuromo): 18.8 g/kg
LD50 (gonzo, SC): 3.7 g/kg
Inosanganisirwa muFDA Inactive Ingredients Database: α-Cyclodextrin (majekiseni ekugadzirira);β-Cyclodextrin (mahwendefa emuromo, topical gels);γ-Cyclodextrin (IV jekiseni).Inosanganisirwa muCanada Rondedzero Yezvinogamuchirwa Zvisiri-Mushonga Ingredients (kudzikamisa agent; solubilizing agent);uye mune oral and rectal pharmaceutical formulations ane rezinesi muEurope, Japan, uye USA.
Basa
1. Kuwedzera kunyungudika kwemishonga uye kuwanikwa kwebiological
2. Kuvandudza bioavailability yemishonga.
3. Kugadzirisa kana kudzora kuburitswa kwezvinodhaka.
4. Kuderedza chepfu yezvinodhaka.
5. Kuvandudza kugadzikana kwezvinodhaka.
Application
Cosmetic:
1. Kuti zvienderane ne encapsulation ye volatile compounds.
2. Kuwedzera hupenyu hwesherufu hwezvinodhura zvinonaka.
Chikafu:
1. Kudzivirira kubuda kwezvinhu zvinoputika.
2. Kubvisa kunhuwa kunotyisa.
3. Kuwedzera zvakanyanya mhedzisiro ye emulsification.
4. Kuita kuchengetedza kwekusunungurwa kwezvokudya.
1. β-Cyclodextrin inoshandiswa mumhizha yezvokudya kuti isunungure mishonga yezvokudya uye zvigadziriswe zvishoma nezvishoma, kuvandudza maitiro ekuchengetedza, kuwedzera hupenyu hwesherufu yezvokudya, nekuvandudza kuravira kwezvokudya, kuwedzera kukwanisa emulsifying uye kudzivisa unyoro.
2. β-Cyclodextrin inoshandiswa zvakanyanya muindasitiri yemishonga yemishonga kuti iwedzere kugadzikana kwemishonga, kudzivirira oxidation uye kuora kwechirwere, kunatsiridza kupera uye bioavailability yemushonga, kuderedza chepfu uye migumisiro yechirwere, uye mask kunhuwa kwemushonga uye kunhuwa.
3. Muindasitiri yezvizoro, β-Cyclodextrin inogona kudzivirira zvizoro zvekuchenesa zvizoro kubva pakukuvadza ropa acid oxidation uye browning, kunatsiridza kuchena uye kuderedza kutsamwa.
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