D-(+)-Cycloserine CAS 68-41-7 Assay ≥ 900μg/mg Factory High Quality
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira D-(+)-Cycloserine (CAS: 68-41-7) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, madiki uye akawanda akawanda aripo.Tenga D-(+)-Cycloserine,Please contact: alvin@ruifuchem.com
| Chemical Name | D-(+)-Cycloserine |
| Mashoko anoreva zvakafanana | D-Cycloserine;(+)-Cycloserine;(R)-(+)-Cycloserine;(R)-(+)-4-Amino-3-Isoxazolidinone;Orientomycin;Oxamycin;α-Cycloserine |
| Stock Status | Mudura |
| Nhamba yeCAS | 68-41-7 |
| Molecular Formula | C3H6N2O2 |
| Molecular Weight | 102.09 g/mol |
| Melting Point | 137℃ |
| Sensitive | Mhepo Inonzwa, Inonzwa Kupisa |
| Solubility | Soluble mumvura.Zvishoma Soluble muMethanol uye Propylene Glycol.Isingasviki muChloroform uye Ether. |
| Storage Temp. | Nzvimbo Inotonhorera & Yakaoma (2~8℃) |
| COA & MSDS | Available |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Ichena kana Yellowish Crystalline Powder | Zvinoenderana |
| Kutenderera kwakananga [α]20/D | +108.0° kusvika +114.0° (C=5, 2N NaOH) | +111.9° |
| Identification | Ruvara Rwebhuruu Runovandudzwa Zvishoma Nezvishoma | Blue Color |
| Condensation Zvigadzirwa | ≤0.80% (pa286nm) | 0.08% |
| Kurasika paKuomesa | <1.00% | 0.38% |
| Residue paIgnition | <0.50% | 0.10% |
| Masimbi anorema (Pb) | ≤10ppm | <10ppm |
| Volatile Kusachena | ||
| - Methanol | ≤500ppm | <500ppm |
| - Acetone | ≤500ppm | <500ppm |
| Assay (Antibiotics-Microbial Assay) | ≥900μg/mg | 938μg/mg |
| pH | 5.5 kusvika 6.5 | 5.98 |
| FTIR | Conforms | Conforms |
| IR Spectrum | Conforms | Conforms |
| NMR Spectrum | Conforms | Conforms |
| Mhedziso | Ichi chigadzirwa nekuongorora zvinoenderana neyakajairwa USP-35 | |
Cycloserine [68-41-7].
Cycloserine ine potency isingasviki 900µg yeC3H6N2O2 pamg.
Kurongedza uye kuchengetedza-Chengetedza mumidziyo yakaoma.
USP Reference mwero <11>-
USP Cycloserine RS
Kuziva-Dissolve nezve 1 mg mu 10 mL ye0.1 N sodium hydroxide.Ku 1 mL yemhinduro inoguma wedzera 3 mL ye1 N acetic acid uye 1 mL yemusanganiswa, wakagadzirirwa awa imwe isati yashandiswa, yezvikamu zvakaenzana zve sodium nitroprusside solution (1 mu25) uye 4 N sodium hydroxide: ruvara rwebhuruu zvishoma nezvishoma. inovandudza.
Condensation products-Is absorptivity (ona Spectrophotometry uye Light-Scattering <851>) pa 285 nm, yakatemwa mu 0.1 N sodium hydroxide solution ine 0.40 mg per mL haisi kupfuura 0.80.
Kutenderera chaiko <781S>: pakati pe108° ne114°.Test solution: 50 mg per mL, mu 2 N sodium hydroxide.
Crystallinity <695>: inosangana nezvinodiwa
pH <791>: pakati pe5.5 ne6.5, mune imwe mhinduro (1 mu10).
Kurasikirwa pakuomeswa <731> -Dry about 100 mg mu capillar y-stoppered bottle in vacuum pa 60 ℃ kwemaawa matatu: inorasikirwa kwete kupfuura 1.0% yehuremu hwayo.
Zvisaririra pamoto <281>: kwete kupfuura 0.5%, iyo yakatsva yakasara yakanyoroveswa ne 2 mL ye nitric acid uye 5 madonhwe e sulfuric acid.
Kuongorora-
pH 6.8 Phosphate buffer-Gadzirira sezvinorayirwa muBuffer Solutions pasi peMagadzirirwo muchikamu cheReagents, Indicators, uye Solutions.
Mobile phase-Dissolve 0.5 g ye sodium 1-decanesulfonate mu800 mL yemvura, wedzera 50 mL yeacetonitrile uye 5 mL yeglacial acetic acid, uye sanganisa.Gadzirisa ne1 N sodium hydroxide kusvika pH ye4.4.Sefa, uye degas.Ita zvigadziriso kana zvichidikanwa y (ona System Suitability pasi peChromatography <621>).
Kugadzirira kwakajairwa-Kunyungudutsa huremu hwakayerwa nemazvo hweUSP Cycloserine RS mupH 6.8 Phosphate buffer kuti uwane mhinduro ine huwandu hunozivikanwa hunosvika 0.4 mg per mL.
Kugadzirira kweAssay-Kutamisa nezve 20 mg yeCycloserine, yakayerwa nenzira kwayo, kune 50-mL volumetric flask, nyunguduka mukati uye inonatsa ne pH 6.8 Phosphate buffer kusvika kuhuwandu, uye sanganisa.
Chromatographic system (ona Chromatography <621>) -Iyo chromatograph yemvura inogadzirwa ne 219-nm detector uye 4.6-mm × 25-cm column ine 5- µm packing L1.Chiyero chekuyerera chinenge 1 mL paminiti.Iyo tembiricha yembiru inochengetwa panenge pa30 °.Chromatograph the Standard kugadzirira, uye rekodha mhinduro dzepamusoro sekurairwa kweMaitiro: iyo yekusweresa haisi kupfuura 1.8;uye kutsauswa kwakayerwa kwemajekiseni ekudzokorora hakupfuuri 2.0%.
Maitiro-Kuparura jekiseni mavhoriyamu akaenzana (angangoita 10 µL) eGwaro gadziriro uye gadziriro yeAssay muchromatograph, rekodha machromatogram, uye kuyera mhinduro dzepamusoro dzecycloserine.Verenga huwandu, muµg, hweC3H6N2O2 mune yega yega yeCycloserine inotorwa neformula:
50,000(C/W)(rU / rS)
umo C ndiyo fungidziro, mu mg per mL, yeUSP Cycloserine RS muSungano gadziriro;W ndiyo yakawanda, mu mg, yeCycloserine yakatorwa kugadzirira kugadzirira kweAssay;uye rU nerS ndiwo mhinduro dzepamusoro dzecycloserine dzakawanikwa kubva mukugadzirira kweAssay uye gadziriro yeStandard, zvichiteerana.
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma (2~8℃) yekuchengetera kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Hazard Symbols Xn - Zvinokuvadza
Risk Codes
R5 - Kupisa kunogona kukonzera kuputika
R20 - Inokuvadza nekufema
Tsanangudzo Yekuchengetedza
S38 - Kana pasina mhepo yakakwana, pfeka midziyo yekufema yakakodzera.
S36/37 - Pfeka zvipfeko zvekudzivirira zvakakodzera uye magurovhosi.
S24/25 - Dzivisa kusangana neganda nemeso.
WGK Germany 2
RTECS NY2975000
FLUKA BRAND F CODES 10-23
HS Code 2941909099
D-(+)-Cycloserine (CAS: 68-41-7) ine yakasimba hygroscopic nature, inonyungudika mumvura, inonyungudika zvishoma mumadoro akaderera, acetone uye dioxane, uye isinganyanyi kunyungudika mu chloroform uye petroleum ether.Iyo inenge yakagadzikana mune alkaline solution uye inoparara nokukurumidza mu acidic kana neutral solutions.Semushonga unorwisa mabhakitiriya wakafara, cycloserine inhibitive kurwisa mabhakitiriya mazhinji eGram-positive uye Gram-negative, rickettsia nemamwe protozoa, kunze kweMycobacterium tuberculosis. Vinactane para-aminosalicylic acid, isoniazid uye pyrazinamide.Cycloserine inobatana zvishoma neisoniazid mukuvharisa Mycobacterium tuberculosis H37RV, asi haikoshese kana kupikisa streptomycin.Chigadzirwa chacho bacteriostatic agent, uye nekudaro haizoite bactericidal mhedzisiro kunyangwe ichiwedzera dosi kana kurebesa nguva yekuita nebhakitiriya.
Iyo Mechanism yeD-cycloserine's antibacterial action ndeye kuvharidzira biosynthesis ye peptidoglycan yemadziro esero.Sezvo iri analog yemaitiro eD-alanine, D-cycloserine inogona kukwikwidzana inhibisa mabasa ealanine racemase uye D-alanyl-D-alanine synthetase, ayo ari maviri akakosha enzymes mu peptidoglycan synthesis.D-cycloserine inotaridza kusasimba kwekudzivirira kuita kurwisa Mycobacterium tuberculosis inongori 1/10 kusvika 1/20 iyo yestreptomycin.Kubatsira kwechigadzirwa ndechekuti chinoshanda pamishonga isingarambiki eMycobacterium tuberculosis strains uye kashoma kukonzeresa kuramba zvinodhaka.Chigadzirwa chacho chinogona kushandiswa nemimwe mishonga inorwisa-tuberculosis mukurapa kwechirwere chetachiona chinokonzerwa nemishonga isingagadziriswi Mycobacterium tuberculosis.
Cycloserine mushonga wepiri-mutsara unorwisa tuberculosis.Inogona kutadzisa kukura kweMycobacterium tuberculosis, asi mhedzisiro yacho haina kusimba kupfuura iyo yemishonga yekutanga.Kushanda kwayo mukurapa tibhii kwakaderera.Kushandisa mushonga chete kunogona kuburitsa kusanzwa kwemishonga, asi kuramba kunoitika zvishoma nezvishoma kana kuchienzaniswa nekwemamwe mishonga inorwisa TB.Hapana kupesana-kupikisa kwakawanikwa pakati pe cycloserine nemamwe mishonga inorwisa-tuberculosis.Iyo nzira yeayo antibacterial chiito ndeye kuvharidzira synthesis ye peptidoglycan yebhakitiriya sero madziro, zvichikonzera kukanganisa mumasero emadziro ekuvaka.Chinhu chikuru chechimiro chebhakitiriya cell wall ndeye peptidoglycan, iyo inoumbwa neN-acetylglucosamine (GNAc) uye N-acetylmuramic acid (MNAc).N-acetylmuramic acid yakabatana nepentapeptide uye inobatanidza N-acetylglucosamine nenzira yakadzokororwa uye neimwe nzira.Kuumbwa kwe cytoplasmic peptidoglycan precursor inogona kukanganiswa ne cycloserine, sezvo iyo yekupedzisira inogona kukanganisa racemase uye synthetase yeD-Alanine, uye nokudaro inovhara kuumbwa kweN-acetylmuramic acid.
D-Cycloserine inogona kuwanikwa kuburikidza nekuvirisa nzira kana kuburikidza yakananga synthesis.Utachiona hunoshandiswa mukuvirisa ndeye Actinomyces laven-dulae.Iyo yekuvirisa svikiro ine dextrin, dextrose, starch, soya bean hupfu, mbiriso hupfu, ammonium sulfate, ammonium nitrate, calcium carbonate, sodium chloride, magnesium sulfate uye soya bean mafuta.Muchigadziro chekugadzirisa, D-Cycloserine inowanikwa kubva ku-β-Aminooxy alanine ethyl ester hydrochloride nekuita ne potassium hydroxide mune cyclization reaction.
