DAPT (GSI-IX) CAS 208255-80-5 γ-Secretase Inhibitor Assay >98.0% (HPLC) Factory
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira DAPT (GSI-IX) (CAS: 208255-80-5) ine mhando yepamusoro, γ-Secretase Inhibitor.Ruifu Chemical inopa akateedzana amino acids uye zvinobva.Isu tinokwanisa kupa kuendesa pasirese, zvidiki uye huwandu hwakawanda huripo.Tenga DAPT,Please contact: alvin@ruifuchem.com
| Chemical Name | DAPT |
| Mashoko anoreva zvakafanana | GSI-IX;γ-Secretase Inhibitor IX;gamma-Secretase Inhibitor;LY-374973;(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu;(3,5-Difluorophenylacetyl)-L-Alanyl-L-2-Phenylglycine tert-Butyl Ester;N-[N-(3,5-Difluorophenacetyl)-L-Alanyl]-S-Phenylglycine t-Butyl Ester;(2S)-N-[2-(3,5-Difluorophenyl)acetyl]-L-Alanyl-2-Phenyl-glycine 1,1-Dimethylethyl Ester |
| Stock Status | Mudura |
| Nhamba yeCAS | 208255-80-5 |
| Molecular Formula | C23H26F2N2O4 |
| Molecular Weight | 432.47 |
| Density | 1.213 g/cm3 |
| Melting Point | 142.0~146.0℃ |
| Sensitive | Heat Sensitive |
| Solubility | Soluble muDMSO |
| Storage Temp. | Chengetedza pa2-8 ℃ |
| COA & MSDS | Available |
| Brand | Ruifu Chemical |
| Safety Statements | 24/25 - Dzivisa kusangana neganda nemeso. | ||
| WGK Germany | 3 | HS Code | 2922491990 |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Ichena kana Isina-White Crystalline Powder | Conforms |
| Kurasika paKuomesa | <0.40% | 0.21% |
| Residue paIgnition | <0.40% | 0.20% |
| Heavy Metals (as Pb) | ≤20ppm | <20ppm |
| Assay / Analysis Method | >98.0% (HPLC) | 98.62% |
| Carbon neElemental Analysis | 62.1~64.1% | Conforms |
| Nitrogen neElemental Analysis | 6.20 ~ 6.70% | Conforms |
| Infrared Spectrum | Inopindirana neChimiro | Conforms |
| NMR Spectrum | Inopindirana neChimiro | Conforms |
| Mhedziso | Ichi Chigadzirwa neKuongorora Zvibvumirano neiyo Enterprise Standard | |
| Sherufu Hupenyu | 24 Mwedzi Kubva Kugadzirwa Zuva Kana Yakachengetwa Zvakanaka | |
Package: Fluorinated Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa painotonhorera, yakaoma (chitoro pa2-8 ℃) uye imba yekuchengetera inofefetera kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
DAPT (GSI-IX) (CAS: 208255-80-5), yakasimba uye yakananga inhibitor ye γ-secretase.DAPT inhibitor ye γ-secretase (IC50 in human primary neurons = 115 nM yeAβ yakazara kana 200 nM yeAβ42 zvakananga).Oral administration yeDAPT yakaratidzwa kuderedza mazinga eAβ muuropi yakatorwa, cerebrospinal fluid uye plasma kubva kumakonzo nemakonzo.DAPT inovharira Notch kusaina iyo inosimudzira mutsauko weuronal weanotangira maseru.Inovandudza iPS masero asina oncogenes KLF4 uye CMYC5.Cell permeable.DAPT inoshandiswa mukudzidza kwe β-amyloid formation.DAPT yakaratidza kuvharidzira Notch kusaina muzvidzidzo zve autoimmune uye lymphoproliferative zvirwere, zvakadai seALPS uye lupus erythematosus, pamwe nekenza masero kukura, angiogenesis, uye kusiyanisa kwevanhu induced pluripotent stem masero.Inhibits Notch kusaina in vitro.Inhibits kugadzirwa kweAβ neAβ42 mutsika dzekutanga dzevanhu (IC50 values ndeye 115 uye 200 nM, zvichiteerana) pasina mhedzisiro pamazinga eAPPα neAPPβ.Ropa-uropi chipingamupinyi chinopindika.3D Kukura matrix chikamu uye chikamu checerebral organoid kusiyanisa media.
