Darunavir Ethanolate CAS 635728-49-3 Purity ≥99.0% API Factory Anti-HIV HIV Protease Inhibitor
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| Chemical Name | Darunavir Ethanolate |
| Mashoko anoreva zvakafanana | DRV;Prezista;TMC114 Ethanolate;UNII-33O78XF0BW;N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro [2,3-b]furan-3-yl ester compd.pamwe ethanol |
| Nhamba yeCAS | 635728-49-3 |
| Nhamba yeCAT | RF-API69 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram |
| Molecular Formula | C29H43N3O8S |
| Molecular Weight | 593.73 |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Ichena kana Isina-White Crystalline Powder |
| Kuzivikanwa IR | Inopindirana neStandard Spectrum |
| Specific Rotation | -0.5°~ +0.5° |
| Related Substances | (neHPLC) |
| Max Single Kusachena | ≤0.20% |
| Zvose Zvisina Kuchena | ≤0.50% |
| Mvura (KF) | ≤1.0% |
| Residue paIgnition | ≤0.10% |
| Heavy Metals | ≤10ppm |
| Zviri mukati meEthanol | ≤7.5% (GC) |
| Residual Solvents | Methanol ≤0.30% |
| Kuchena | ≥99.0% (HPLC) |
| Test Standard | Enterprise Standard |
| Usage | Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral |
Package: Bhodhoro, Aluminium foil bag, Cardboard Drum, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
Darunavir Ethanolate (Prezista) mushonga weHIV protease inhibitor.Derivative yeDarunavir, chizvarwa chechipiri HIV-1-protease inhibitor;zvakarongeka zvakafanana neamprenavir.Antiviral.Icho chigadzirwa chekutsvaga chine chekuita neCOVID19.Sezvineiwo, DRV ine kunyungudika kwakaderera mumvura uye kushomeka kwebioavailability, saka inoda kutonga mune yakakwira madosi kuitira kuratidza kurapa kwakanaka.Darunavir ndeye wide-spectrum ine simba inhibitor inoshanda kurwisa HIV-1 kiriniki inozvitsaura ine cytotoxicity shoma.Darunavir inoumba hydrogen zvisungo nemaatomu makuru akachengetwa eAsp29 uye Asp30 eprotease.Kudyidzana uku kunofungidzirwa kuve kwakakosha pakusimba kwekomboni iyi pakurwisa hutachiona hweHIV hunoshingirira kune akawanda maprotease inhibitors.Muchidzidzo che in vitro mumasero eMT-2, simba redarunavir rakakura kudarika resaquinavir, amprenavir, nelfinavir, indinavir, lopinavir uye ritonavir.Darunavir inonyanya kushandiswa nehepatic cytochrome P450 (CYP) enzymes, kunyanya CYP3A.Iyo 'boosting' dose ye ritonavir inoita inhibitor yeCYP3A, nokudaro ichiwedzera darunavir bioavailability.Darunavir yakagadzirirwa kuumba kudyidzana kwakasimba neprotease enzyme kubva kune akawanda marudzi eHIV, kusanganisira madhiri kubva kuvarwere vane ruzivo rwekurapa vane multiple resistance mutati.
