Desmopressin Acetate CAS 16789-98-3 Peptide Purity (HPLC) ≥98.5% Factory

Hazard Symbols Xn - Zvinokuvadza
Risk Codes 20 - Zvinokuvadza nekufema
Tsanangudzo Yekuchengetedza 36 - Pfeka zvipfeko zvinodzivirira zvakakodzera.
WGK Germany 3

Desmopressin Acetate (CAS: 16789-98-3) kureva, 1-cysteine ​​deamination uye 8-D-arginine panzvimbo ye8-l-arginine, inozivikanwawo se arginine vasopressin, inofananidzira analog ye naturalarginine vasopressin, yakabva kune vasopressin, iyo antidiuretic effect ine simba uye inogara kwenguva refu kupfuura vasopressin, asi hapana vasoconstrictor effect, zvinodhaka zvinokonzerwa nemishonga, kliniki yekuberekwa kana zvinodhaka-induced platelet dysfunction, uremia, chiropa cirrhosis uye zvikonzero zvisingazivikanwi zvinokonzerwa nekubuda ropa kwenguva refu;Inogona kushandiswa kudzora uye kudzivirira kubuda ropa panguva yekuvhiyiwa kudiki;Central chirwere cheshuga insipidus.Muzviitiko zvega, chigadzirwa ichi chinotoburitsa kushanda muvarwere vane mwero weti system zvirwere, kazhinji kuremara kune varwere vane Type IIB von Willebrand chirwere.
Pharmacological action: Desmopressin Acetate ine desmopressin iyo yakarongeka yakafanana neyekuzvarwa arginine vasopressin.Ndiwo musiyano uripo pakati pearginine vasopressin, kunyanya kwehafu yeamino acid uye D arginine kutsiva L Arginine.Idzi shanduko dzezvimiro dzinowedzera nguva yekuita kwekiriniki dosi ye desmopressin pasina mhedzisiro yekumanikidza.Zvimwe zvidzidzo zvakaratidza kuti mhedzisiro yeanti-enuresis yakakosha, iyo inogona kunge iri nekuda kwekuwedzera kwearginine vasopressin mazinga muropa revana usiku, uye ipapo kuisa pfungwa paurini, kuderedza weti vhoriyamu uye intravascular pressure, kuderera kwemutsipa uye. detrusor contraction.
Kushanda kwayo, kusununguka kwekutonga (intranasal), nguva yakareba yekuita, uye kushayikwa kwemigumisiro inoita kuti ive mushonga wekusarudza kurapa kwepakati diabetesinsipidus.Inogona zvakare kupihwa intramuscularly orntravenously.Inosarudzwa kune vasopressin jekiseni uye oral antidiuretics kuti ishandiswe muvana.Inoratidzwa mukutonga kwepolydipsia yenguva pfupi uye polyuria yakabatana nekukuvara kune, kana kuvhiyiwa, munzvimbo yepituitary.
Kushandiswa Kwechipatara: Desmopressin, semunyu weacetate, inofananidzira analogue yevasopressin umo N terminal Cys isina α-amino basa (1-Deamino) uye apo Arg8 iripo seD-isomer (D-Arg8) , saka chirevo chekutengeserana DDAVP.Kuvapo kweD-Arg uye kusavapo kweN-terminal amine muchimiro che desmopressin kwakawedzera hafu yehupenyu hwayo zvekuti inowanikwa nemuromo, parenteral, kana nasal kushandiswa.Inoshandiswa nezvose zvitatu zveiyi nzira dzehutungamiri kudzivirira kana kudzora polydipsia (nyota yakawandisa), polyuria, uye kupera simba kwevarwere vane chirwere cheshuga insipidus chinokonzerwa nekushayikwa kwevasopressin.Iyo zvakare yakatenderwa kurapwa kwehusiku enuresis (mubhedha-wetting), iyo inofungidzirwa kuti inokonzerwa nekusavapo kweyakajairika nguva yehusiku kusimuka mumazinga evasopressin.Desmopressin inozivikanwa kuti inokonzera kuwedzera mune zvose plasma factor VIII (antihemophilic factor) uye plasminogen activator.Naizvozvo inotenderwa neUS FDA kuti ishandiswe, muvabereki uye nemumhino, mukuderedza kubuda kweropa kana kukuvadzwa-kunokonzerwa nevarwere vane hemophilia A uye mhando I Von Willebrand's chirwere, chero basa ravo replasma factor VIII rakakura kupfuura 5%.Stimate, mushonga wemhino unoshandiswa mukurapa varwere vane hemophilia A uye mhando I Von Willebrand's hosha, ndeye 15-yakapetwa kuwanda kweDDAVP nasal spray;iyo yekupedzisira inoshandiswa mukurapa chirwere cheshuga insipidus.