Diflorasone Diacetate CAS 33564-31-7 Assay 97.0~103.0% Factory Corticosteroid

Diflorasone Diacetate [33564-31-7]
»Diflorasone Diacetate ine kwete pasi pe97.0 muzana uye kwete kupfuura 103.0 muzana yeC26H32F2O7, yakaverengerwa pane yakaomeswa.
Kurongedza uye kuchengetedza-Chengetedza mumidziyo yakaoma.
USP Reference mwero <11>-
USP Diflorasone Diacetate RS
Kuzivikanwa, Infrared Absorption <197M>.
Kutenderera chaiko <781S>: pakati pe +58° uye +68°.Test solution: 20 mg, isina kuomeswa, pamL, mu chloroform.
Kurasikirwa pakuomeswa <731> -Dry it in vacuum pa 60 ° uye pakumanikidzwa kusingapfuuri 5 mm ye mer cury kwemaawa gumi nematanhatu: inorasikirwa isingapfuuri 0.5% yehuremu hwayo.
Zvisaririra pakubatidza <281>: kwete kupfuura 0.5%
Chromatographic kuchena-
Nharembozha chikamu uye Chromatographic system-Gadzirira sekurairwa muAssay.
Test solution-Dissolve huremu hwakayerwa nemazvo hweDiflorasone Diacetate mumvura-yakazara chloroform kuti uwane mhinduro ine musanganiswa unosvika 6 mg pa mL.
Maitiro-Baya vhoriyamu (inenge 10 µL) yeMuedzo mhinduro muchromatograph, rekodha chromatogram kwenhambo yakaenzana nekashanu nguva yekuchengeta yenhongonya huru, uye kuyera nzvimbo dzepamusoro pese.Verenga chikamu chekusachena kwega kwega muchikamu cheDiflorasone Diacetate chakatorwa neformula:
100(ri/rs)
umo ri ndiyo nzvimbo yepamusoro yekusachena kwega kwega;uye rs ndiyo nhamba yenzvimbo dzepamusoro pese: kwete kupfuura 1.0% yehupi husina kuchena hunowanikwa;uye kwete kupfuura 2.0% yetsvina yose inowanikwa.
Kuongorora-
Nharembozha-Gadzirira mhinduro ine musanganiswa wemvura-yakazara n-butyl chloride, mvura-yakazara methylene chloride, glacial acetic acid, uye tetrahydrofuran (350:125:15:10).Ita zvigadziriso kana zvichidikanwa (ona System Suitability pasi peChromatography <621>).
Internal standard solution-Uchishandisa mvura-saturated chloroform, gadzirira mhinduro ye isoflupredone acetate ine inenge 0.04 mg per mL.
Kugadzirira kwakajairwa-Dyisa huremu hwakayerwa nemazvo zveUSP Diflorasone Diacetate RS muInternal standard solution kuti uwane mhinduro ine huwandu hunozivikanwa hunosvika 33µg per mL.
Kugadzirira kweAssay-Kutamisa nezve 15 mg yeDiflorasone Diacetate, yakanyatsoyerwa, kune 500-mL volumetric flask.Wedzera Yemukati mwero mhinduro kune vhoriyamu, uye sanganisa.
Chromatographic system (ona Chromatography <621>) -Iyo chromatograph yemvura inogadzirwa ne 254-nm detector uye 4.6-mm × 10-cm column ine 3- µm packing L3.Chiyero chekuyerera chinenge 2.5 mL paminiti.Chromatograph the Standard kugadzirira, uye rekodha nzvimbo dzepamusoro sekurairwa kwaProcedure: sarudzo, R, pakati peanalyte uye yemukati mwero peaks haisi pasi pe12;uye kutsauswa kwakajairika kweasingasviki mana majekiseni anodzokorora haasi anopfuura 2.0%.
Maitiro-Kuparura jekiseni mavhoriyamu akaenzana (angangoita gumi µL) eChimiro gadziriro uye gadziriro yeAssay muchromatograph, rekodha machromatogram, uye kuyera nzvimbo dzepamusoro-soro.Nguva dzekuchengeta dzinenge 1.0 ye diflorasone diacetate uye 2.4 yeyemukati mwero.Verenga huwandu, mu mg, hweC 26H32F2O7 muchikamu cheDiflorasone Diacetate chakatorwa neformula:
0.5C(RU / RS)
umo C ndiyo chiyero, mu µg per mL, ye USP Diflorasone Diacetate RS muStandard gadziriro;uye RU neRS ndiwo mareshiyo enzvimbo dzepamusoro dzeDiflorasone Diacetate uye nzvimbo dzemukati dzemukati dzakawanikwa kubva mukugadzirira kweAssay uye Kugadzirira Kwemaitiro, zvichiteerana.