DMF-DMA CAS 4637-24-5 N,N-Dimethylformamide Dimethyl Acetal Purity >99.0% (GC) Factory Hot Sale

Sezvo Meenvin akashuma kugadzirirwa kweDMF-DMA (N, N-Dimethylformamide Dimethyl Acetal) mu1956, DMF-DMA yakave reagent inowanzoshandiswa mukugadzirwa kwehupenyu.
DMF-DMA inoshandiswa zvakanyanya mukuvaka zvindori zvishanu kana zvitanhatu zveheterocyclic mumhete yekuvhara.DMF-DMA ine maitiro akapfava uye goho repamusoro, kunyanya kune yakanyanya kupikisa makomisheni.
Iyo yakajairika chimiro cheamide acetal makomisheni ndeiyi inotevera:
Iyo inonyanya kushandiswa ndeye DMF-DMA uye DMF-DEA, amide acetal iri nyore hydrolyzed, inogona kuve esterified, amidine, alkylation uye cyclization maitiro.
Iyo yepakati kabhoni atomu yeDMF-DMA yakabatana nemaheteroatomu matatu ane hombe electronegative, izvo zvinoita kuti ive yakasimba electrophilic chiitiko.Pasi pekuita kweasidhi, alkoxy boka riri nyore kusiya, uye maion akanaka ane simba remagetsi emagetsi anowanikwa.Kuita kweDMF-DMA kunonyanya kusanganisira methylation reaction uye maitiro ekuita.
"One-carbon Syntheson" yeDMF-DMA
Mukuita kwekuvhara loop kunosanganisira DMF-DMA, kabhoni atomu imwe chete muchigadzirwa inowanzopihwa neDMF-DMA, saka DMF-DMA inogona kutorwa secarbon syntheson.
DMF-DMA esterification reaction
DMF-DMA esterification inogonesa akasiyana carboxylic acids kuburitsa nyore C1-20 alkyl kana aryl esters, uye byproducts inogona kupatsanurwa zviri nyore ne distillation.
Adipic acid uye DMF-DMA dzakasimbiswa pa80 degrees kwemaawa maviri.Amide acetal isarudzo yakanakira esterification yeimwe carboxylic acid ine steric chipinganidzo kana kusagadzikana.
Kuita kweDMF-DMA amidination uye kuchengetedzwa kwemamines ekutanga
Amide acetals inogona kuita kwete chete nemaamine ekutanga, asiwo neamides, carbamates, sulfonamides kugadzira hydrocarbon bonds.
Zvakadai se: 2, 4-dimethyl aniline uye DMF-DMA pa80 degrees inogona kukurumidza kubvisa methanol kuti iite dimethamidine compounds.
DMF-DMA inogona zvakare kushandiswa seyekutanga amine kudzivirira boka, rekutanga amine kuchengetedza boka (2 NH kuchengetedzwa kwese) pamwe vanhu vazhinji vanofunga nezve phthalyl, pyrrole ring, kaviri Boc, kaviri PMB, nezvimwewo, asi DMF-DMA kuchengetedzwa kwepuraimari. amine, mune zvimwe zviitiko zvakare inobatsira kwazvo kuchengetedza chirongwa, kubva pakudzivirira kunongoda TFA musanganiswa.
Amino dziviriro - 13 yakajairika yekudzivirira base sumo, yekudzivirira base sarudzo ruzivo, huwandu hwemashandisiro, sumo mamiriro, ekubvisa mamiriro ekugovana pfupiso.
DMF-DMA inopindirana neanoshanda methyl uye methylene mapoka kuumba kabhoni-kabhoni kaviri zvisungo
Phenylmethylation yeDMF-DMA
Heterocyclic compound reactions muDMF-DMA
Amide acetal seyemwe kabhoni donor inogona kushandiswa kugadzira akasiyana akaomesesa komisheni uye biomimetic zvakasikwa zvinhu.Actedes Actedels inogona kuvezwa: 1,2.4 Trazole, 1,2, 4 Traridencule, Pyrimiline, Oxazoelone, Oxazoelone, yeammonia heterocyclic derivatives, inogonawo kugadzirwa oksijeni, sulfur heterocyclic compounds.
Zvinoenderana nerudzi rwekuita kwemakemikari, kushandiswa kweamide acetal muheterocyclic compound synthesis inogona kukamurwa kuita zvinhu zvitatu zvinotevera.
(1): amide acetal uye amine, amide, carbamate lipid reaction, inogadzira zvindori zvakasiyana-siyana zveheterocyclic
Amidoacetal uye amine reaction kune formamidine yepakati, uyezve intramolecular nucleophilic ring reaction kuti ibudise zvakasiyana-siyana heterocycles, kana formamidine uye hydrazine, hydroxylamine, l, 2, imwe kana maviri alkyl halides ane mapoka maviri anoshanda emakemikari pamwe nekabhoni refu refu, uyezve intramolecular ring. .
Synthesis of heterocyclic compounds nekuita kweamide acetals uye amides, zvakadai sekugadzirwa kwel, 2,4 monotriazole derivatives.Chekutanga, acetal inopindirana neamide kuita N, N 'tritradil, yozorira ne phenylhydrazine kuita L, 2,4 monotriazole derivatives.
Amide acetals inopindirana necarbamic acid kana acetate kuita chlorine-containing heterocyclic rings.Diactive yepakati inoumbwa nekuita kweamide acetal ine aminoethyl ester: nn-dimethyl-n 'alkyl-carboxymethyl formamidine, iyo inopindirana nehydrazine kana inotsiva hydrazine.Semuenzaniso, pakugadzirira kwe1,2,4 triazinone-6, iyo equation inoratidzwa pasi apa.Kana iwe ukazviita ne nitro-formate unowana 1,2,4 triazolone-5.
Reaction nzira yekuumbwa kwe1,2,4 triazolone-5
Kuumbwa kwe 1.2.4- triazolidin-5 matanho maviri.Kutanga, ethyl carbamate uye DMF diformaldehyde acetals inoumba yepakati Nn-dimethyl-n-ethoxy-formamidine.Chechipiri, boka reamino pane phenylhydrazine rinoparadza kabhoni pane formamidine, iyo inorasikirwa -N (CH3).Ipapo ammonia paringin ye benzene pedyo ne phenylhydrazine inorwisa kabhoni paboka rekabhoni, ichiita anion yeokisijeni, uye maerekitironi maviri ari paokisijeni odzika, orasa boka re ethoxy, uye oburitsa 1.2, 4-triazolone-5.
(II) Kugadzirira kwemishonga yeheterocyclic nekuita kweamide acetal uye amide
Iyi ndiyo nzira inonyanya kushumwa ye synthesis tsvina mumakumi emakore achangopfuura.Chiito cheamide acetal chakaenzana neGrignard reagent, asi maitiro ekuita amide acetal ari nyore uye akapfava.
Amide acetal ine mapoka maviri anoshanda, high reactivity, uye inoshanda methyl, methylene reaction kuti iite amidine intermediates, inogona kuva imwezve maitiro, kuvhara mhete, uye Grignard reagent uye methylene reaction, kungorebesa kabhoni ketani, haigoni kuwedzera kuita.Semuenzaniso, synthesis yefuranochroone derivatives.
(3): amide acetal uye hydroxyl, sulfhydryl compound reaction kuti ibudise oxygen, sulfur heterocyclic compounds
Iyo iri pamusoro apa synthesis yefuro kupedzane muenzaniso wakanaka weacetal generation yeanomine derivatives uye hydroxyl group nekuparadzanisa endolateral pole, zvichiita kuti oxy-containing heteramine:.Mumwe muenzaniso: catechol neDMF -- DMA inoumba mhete dzine oxygen pamberi pedichloromethane.
Kuita kweDMF -- DMA uye o-mercaptoaniline inogona kuburitsa sulfur-ine heterocyclic ring, maitiro ekuita ndeaya anotevera.
Nyaya yekudzidza yeDMF-DMA mhete yekuvhara maitiro uye maitiro emunhu
(1) Batcho-Leimgruber indole synthesis
Kugadzirira kwakasiyana-siyana kweVindol kubva ku o-nitrotoluene.
Reaction mechanism
Chekutanga pane zvese, dimethylformamide dimethylacetal, iyo yakaipa ion yeboka remethoxy inosiya kuti ibudise yakawedzera reactive yepakati.Inorwiswa necarboanions inoumbwa nekuderera kwe o-nitrotoluene methyl hydrogen uye inorasikirwa nemethanol kuti iwane enylamine yataurwa pamusoro apa.Chigadzirwa chedanho iri, enamine, chakafanana nealkene ine electron-kubvisa uye maelectron-donating substituents akabatanidzwa kumativi ese (Push-pull olefin yakasimba polar uye kazhinji yakasvibira mutsvuku nekuda kwehukuru hwekusangana mumorekuru. Mudanho repiri. yemaitiro, boka re nitro rakaderedzwa kuita boka reamino, rinoteverwa necyclization uye kubviswa kuti uwane chigadzirwa chekupedzisira.
(2) Mifananidzo yakasanganiswa yepyridine derivatives
(3) Synthesis ye pyrazole derivatives