Docetaxel CAS 114977-28-5 Assay 98.0%~102.0%
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri weDocetaxel (Taxotere) (CAS: 114977-28-5) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Docetaxel,Please contact: alvin@ruifuchem.com
| Chemical Name | Docetaxel |
| Mashoko anoreva zvakafanana | Taxotere;Taxotere Anhydrous;Docetaxel Anhydrous;N-Debenzoyl-N-tert-Butoxycarbonyl-10-Deacetyltaxol;RP-56976 |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 114977-28-5 |
| Molecular Formula | C43H53NO14 |
| Molecular Weight | 807.89 g/mol |
| Melting Point | 186.0~192.0℃(Zvita.) |
| Density | 1.38 |
| Solubility | Yakanyanya Soluble muAcetone, Dimethylformamide.Soluble muEthanol, Dichloromethane, Methanol.Insoluble muMvura |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Zvinotsanangurwa | Results |
| Chitarisiko | White Crystalline Powder | White Crystalline Powder |
| Identification | IR & HPLC | Conforms |
| Kutenderera kwakananga [a]20/D | -42.0° kusvika -45.0° (C=1 muEtOH) | -43.1° |
| Kurasika paKuomesa | <3.00% | 2.05% |
| Residue paIgnition | <0.10% | 0.04% |
| Masimbi anorema (Pb) | ≤20ppm | <20ppm |
| Arsenic (As) | ≤1.5ppm | <1.5ppm |
| Related Substances | ||
| Maximum Single Kusachena | <0.50% | <0.50% |
| Zvose Zvisina Kuchena | <1.00% | <1.00% |
| Microbial Limit Miedzo | ||
| TAMC | ≤100cfu/g | <100cfu/g |
| TYMC | ≤10cfu/g | <10cfu/g |
| Bacterial Endotoxins | ≤0.3IU/mg | <0.3IU/mg |
| Assay / Analysis Method | 98.0%~102.0% (Pamusoro peAnhydrous uye Solvent-Free Basis) | 100.9% |
| Mhedziso | Chigadzirwa chakaedzwa uye chinoenderana nezvakapihwa | |
Package:Fluorinated Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Kuchengeta:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.Hazvienderani neakasimba oxidizing agents.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Hazard Symbols Xi - Irritant
Risk Codes
R36/37/38 - Kushungurudza maziso, kufema system uye ganda.
R61 - Inogona kukonzera kukuvadza kumwana asati aberekwa
Tsanangudzo Yekuchengetedza
S26 - Kana wasangana nemaziso, simbura nekukasira nemvura yakawanda uye tsvaga mazano ekurapwa.
S36/37 - Pfeka zvipfeko zvekudzivirira zvakakodzera uye magurovhosi.
S53 - Dzivisa kuratidzwa - wana mirairo yakakosha usati washandisa.
S45 - Kana pakaitika tsaona kana ukanzwa usinganzwe zvakanaka, tsvaga zano rekurapa nekukasira (ratidza chinyorwa pese pazvinogoneka.)
UN IDs 1544
WGK Germany 3
RTECS DA4172750
HS Code 2932999029
Chikamu cheNjodzi 6.1(b)
Kurongedza Boka III
Toxicity LD50 intravenous mumbwa: 2500ug/kg
Docetaxel (Taxotere) (CAS: 114977-28-5) inotengeswa seTaxotere kana Docecad, yakanyatsogadziriswa anti-mitotic chemotherapy mishonga inoshanda nekuvhiringidza kupatsanurwa kwesero.Docetaxel inotenderwa neFDA kuti irapwe kenza yemuno kana metastatic yemazamu, musoro nemutsipa, gomarara remudumbu, kenza yehomoni-refractory prostate uye isiri diki-sero kenza yemapapu.Docetaxel inogona kushandiswa semumiriri mumwechete kana musanganiswa nemamwe madhiragi echemotherapeutic sezvinoratidzwa zvichienderana nerudzi rwegomarara uye nhanho.Docetaxel inhengo ye taxane drug class, iyo inosanganisirawo chemotherapeutic mushonga paclitaxel.Kunyangwe docetaxel ichiramba ine simba zvakapetwa kaviri sepaclitaxel (nekuda kwekuita kwedocetaxel pane centrosome ye mitotic spindle), iwo ma taxane maviri akaonekwa aine kushanda kwakafanana.Zvinyorwa zvakawanda zvichangoburwa zvakawana "hapana humbowo hwekuti regimens ine docetaxel inopa mabhenefiti makuru kupfuura ayo anosanganisira paclitaxel."Nepo kushanda zvakanaka pakati pevamiririri vaviri kwave kucherechedzwa kuve kwakaenzana, paclitaxel inogona kukonzera mashoma mhedzisiro.Pamusoro pezvo, zvakacherechedzwa kuti docetaxel inokonzeresa masero emishonga kuramba kuburikidza nenzira dzakasiyana siyana.
1. Docetaxel ikiriniki yakanyatsogadziriswa anti mitotic chemotherapy mishonga (kureva, inovhiringidza kupatsanurwa kwesero).
2. Docetaxel inoshandiswa zvakanyanya pakurapa mazamu, ovarian, uye isiri-diki kenza yemapapu.
3. Docetaxel ine FDA yakatenderwa kukumbira kurapwa kwevarwere vakakura munharaunda, kana metastatic zamu kana isiri diki-sero kenza yemapapu vakaita anthracycline based chemotherapy uye vakatadza kumisa kukura kwegomarara kana kudzoka zvakare.Kubvumidzwa kweEuropean doce-taxel kushandiswa muhomoni-refractory prostate cancer.
4. Docetaxel inonzi iri nani pane , se cytotoxic antimicrotubule.
