Entecavir Monohydrate CAS 209216-23-9 API Factory High Quality Antiviral Hepatitis B Infection

Tsanangudzo Pfupi

Zita reKemikari: Entecavir Monohydrate

CAS: 209216-23-9

Kuonekwa: Ichena kana Inenge Yakachena Crystalline Powder

Antiviral mushonga unoshandiswa mukurapa Hepatitis B Infection

API High Quality, Commercial Production

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Tsanangudzo:

Mugadziri Wekutengesa ane Kuchena Kwepamusoro uye Hunhu Hwakagadzikana
Zita reKemikari: Entecavir Monohydrate
CAS: 209216-23-9
Inoshandiswa mukurapa Hepatitis B Infection
API High Quality, Commercial Production

Chemical Properties:

Chemical Name	Entecavir Monohydrate
Mashoko anoreva zvakafanana	Entecavir Hydrate;9 - [(1S,3R,4S) -4-Hydroxy-3-(hydroxymethyl) -2-methylenecyclopentyl]guanine Monohydrate
Nhamba yeCAS	209216-23-9
Nhamba yeCAT	RF-API79
Stock Status	MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram
Molecular Formula	C12H17N5O4
Molecular Weight	295.3
Melting Point	>220℃
Density	1.81
Shipping Condition	Yakatumirwa Pasi peAmbient Temperature
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	Ichena kana Inenge Yakachena Crystalline Powder
Solubility	Yakasununguka Soluble muDimethylformamide, Inonyungudika Zvishoma Mumvura, Ethanol uye Methanol
Kuzivikanwa IR	Spectrum yemuenzaniso inoenderana neyereferensi mwero
Kuzivikanwa HPLC	Nguva yekuchengeta yemuenzaniso webvunzo inoenderana neiyo yereferensi mwero
Mvura Yemukati (neKF)	5.5% ~ 6.5%
Specific Optical Rotation	+24.0° kusvika +30.0° (DMF: MeOH=1:1 C=1%) (pachinhu chisina mvura)
Residue paIgnition	≤0.10%
Related Substances
Furoentecavir	≤0.10%
Entecavir 1-Epimer	≤0.10%
Entecavir 3-Epimer	≤0.10%
8-Methyoxy Entecavir	≤0.10%
Entecavir 4-Epimer	≤0.10%
8-Hydroxy Entecavir	≤0.10%
4-Dimethylsilyl Entecavir	≤0.10%
Entecavir Inoenderana Musanganiswa A	≤0.10%
Chero Kusachena Kusina Kutaurwa	≤0.10%
Zvose Zvisina Kuchena	≤0.30%
Residual Solvents
Methanol	≤600ppm
Dichloromethane	≤300ppm
Ethyl Acetate	≤1000ppm
Tetrahydrofuran	≤720ppm
Toluene	≤890ppm
Benzyl Chloride	≤1000ppm
Benzyl Doro	≤1000ppm
Microbial Limit
Total Aerobic Counts	≤100cfu/g
Mbiriso uye Molds	≤10cfu/g
Escherichia Coli	Haifaniri Kuonekwa
Heavy Metals	≤10ppm
Assay	98.0% ~ 102.0% (HPLC; pane anhydrous basis)
Particle Size	95% yezvikamu zvinofanirwa kunge zviri mukati me125um
Test Standard	Enterprise Standard;United States Pharmacopoeia (USP) Standard
Usage	Antiviral mushonga unoshandiswa mukurapa Hepatitis B Infection

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.

Zvakanakira:

FAQ:

Application:

Entecavir Monohydrate (CAS 209216-23-9) inonzi antiviral drug inoshandiswa mukurapa Hepatitis B Virus (HBV) utachiona.Entecavir Monohydrate inonzi nucleoside analog (kunyanya, guanine analogue) iyo inhibits reverse transcription, DNA replication uye kunyora muvira.Iro rudzi rutsva rwe cyclopentyl acyl guanosine anti-Hepatitis B utachiona hwemishonga nemishonga yayo yemishonga yakafanana neEntecavir.Inoshandiswa kuchipatara pakurapa kwevakuru Chronic Hepatitis B umo mune kushingaira kwevhairasi kudzokorora, kuwedzera serum transaminase ALT kana maronda anoshanda anoratidzwa kubva pachiropa histology.Entecavir Monohydrate ine simba uye inosarudza inhibitor yeHBV, ine EC50 ye3.75 nM muHepG2 cell.Entecavir inonzi reverse transcriptase inhibitor.Inodzivirira Hepatitis B Virus (HBV) kuti isawanda uye inoderedza huwandu hwehutachiona mumuviri.