Flurbiprofen CAS 5104-49-4 Assay 99.0~100.5% (HPLC) Factory

Flurbiprofen
C15H13FO2 244.27
(±) -2-(2-Fluoro-4-biphenylyl)propionic acid [5104-49-4].
Flurbiprofen ine kwete pasi pe99.0 muzana uye kwete kupfuura 100.5 muzana yeC15H13FO2, yakaverengerwa pane yakaomeswa.
Kurongedza uye kuchengetedza- Chengetedza mumidziyo yakaoma.
USP Reference mwero <11>-
USP Flurbiprofen RS
USP Flurbiprofen Inoenderana Necompound A RS
2-(4-Biphenylyl)propionic acid.
C15H14O2 226.28
Identification-
A: Infrared Absorption <197K>.
B:Kunyura kweUltraviolet 197U-
Mhinduro: 10 µg pamL.
Pakati: 0.1 N sodium hydroxide.
Absorbance yakawanda pa247 nm inenge 0.8.
Melting range <741>: pakati pe114 ne117.
Kurasikirwa pakuomeswa <731> -Dry it in vacuum pa60 kusvika kune uremu hunoramba huripo: inorasikirwa kwete kupfuura 0.5% yehuremu hwayo.
Residue pakudzima <281>: kwete kupfuura 0.1%.
Heavy metals, Nzira II <231>: 0.001%.
Related compounds-
Diluent-Gadzirira musanganiswa wemvura uye acetonitrile (11: 9).
Nharembozha-Gadzirira musanganiswa wakanatswa uye wakasvibiswa wemvura, acetonitrile, uye glacial acetic acid (12: 7: 1).Ita zvigadziriso kana zvichidikanwa (ona System Suitability pasi peChromatography <621>).
Yakajairwa stock solution- Dissolve huremu hwakayerwa nemazvo eUSP Flurbiprofen Inoenderana Compound A RS muDiluent kuti uwane mhinduro ine muunganidzwa we50 µg pamL.
Kukodzera kweSystem solution-Pipet 2.0 mL yeStandard stock solution mu10-mL volumetric flask, wedzera 20 mg yeUSP Flurbiprofen RS, dilue neDiluent kusvika kuhuwandu, uye sanganisa.
Standard solution-Shandura 2.0 mL yeStandard stock solution kune 10.0-mL volumetric flask, dilue neDiluent kusvika kuhuwandu, uye sanganisa.
Test solution-Gadzirira mhinduro yeFlurbiprofen muDiluent ine 2.0 mg per mL.
Chromatographic system (ona Chromatography <621>) -Iyo chromatograph yemvura inogadzirwa ne 254-nm detector uye 3.9-mm × 15-cm column ine 4-µm packing L1.Chiyero chekuyerera chinenge 1 mL paminiti.Chromatograph iyo Sistimu yakakodzera mhinduro, uye rekodha mhinduro dzepamusoro sekurairwa kwaProcedure: nguva dzekuchengetedza dzinenge 0.9 yeFlurbiprofen ine chekuita nekomboni A uye 1.0 yeflurbiprofen;uye kutsauswa kwakajairwa kwemajekiseni anodzokorora hakupfuuri 1.0%.
Maitiro-Kuparura jekiseni mavhoriyamu akaenzana (angangoita 20 µL) yeStandard solution uye Test solution muchromatograph, rekodha machromatogram, uye kuyera nzvimbo dzepamusoro-soro.Verengai muzana yeflurbiprofen inoenderana nekamu A muchikamu cheFlurbiprofen inotorwa neformula:
100(CS / CU)(rU / rS)
umo CS ndiyo yekuisa, mu µg per mL, ye USP Flurbiprofen Related Compound A RS in the Standard solution;CU ndiyo fungidziro, muµg pa mL, yeFlurbiprofen mumhinduro yeKuedza;uye rU nerS ndiwo mhinduro dzepamusoro dzeflurbiprofen ine chekuita nekomboni A yakawanikwa kubva muyedzo mhinduro neiyo Standard solution, zvichiteerana: haipfuure 0.5% yeflurbiprofen ine chekuita nekomboni A inowanikwa.Verenga chikamu chekusachena kwega kwega muchikamu cheFlurbiprofen chakatorwa neformula:
100(ri/rs)
umo ri ndiyo mhinduro yepamusoro yekusachena kwega kwega kunowanikwa kubva kuMuedzo mhinduro;uye rs ndiyo uwandu hwemhinduro dzenhongonya dzese dzakawanikwa kubva kuMuyedzo mhinduro: huwandu hwetsvina yese haipfuuri 1.0%.
Assay-Dissolve inenge 0.5 g yeFlurbiprofen, yakanyatsoyerwa, mu100 mL yedoro, yakambove isina kusimba ne 0.1 N sodium hydroxide VS kune phenolphthalein endpoint, wedzera phenolphthalein TS, uye titrate ne 0.1 N sodium hydroxide VS kune yekutanga kutaridzika kwekutanga. pink color inoramba iripo kweasingasviki masekonzi makumi matatu.Imwe mL ye0.1 N sodium hydroxide yakaenzana ne 24.43 mg yeC15H13FO2.