Fmoc-Leu-OH CAS 35661-60-0 N-Fmoc-L-Leucine Kuchena >99.0% (HPLC) Factory
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) ine mhando yepamusoro.Ruifu Chemical inopa akatevedzana amino acids.Isu tinokwanisa kupa kutakura kwepasirese, mutengo wemakwikwi, madiki uye akawanda akawanda aripo.Kutenga Fmoc-Leu-OH,Please e-mail: alvin@ruifuchem.com
| Chemical Name | N-Fmoc-L-Leucine |
| Mashoko anoreva zvakafanana | Fmoc-Leu-OH;Fmoc-L-Leu-OH;Fmoc-L-Leucine;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-Leucine;N-(9-Fluorenylmethoxycarbonyl)-L-Leucine |
| Stock Status | MuStock, Kukwanisa Kugadzira kusvika Matani pamwedzi |
| Nhamba yeCAS | 35661-60-0 |
| Molecular Formula | C21H23NO4 |
| Molecular Weight | 353.42 g/mol |
| Melting Point | 153.0 kusvika 160.0 ℃ |
| Density | 1.207±0.06 g/cm3 |
| Sensitive | Hygroscopic |
| Solubility muMethanol | Kuda Kujeka |
| Storage Temp. | Nzvimbo Inotonhorera & Yakaoma (2~8℃) |
| COA & MSDS | Available |
| Category | Fmoc-amino Acids |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | White Powder | White Powder |
| Kutenderera kwakananga [α]20/D | -25.0°±2.0° (C=1 muDMF) | -24.6° |
| Melting Point | 153.0 kusvika 160.0 ℃ | 155.1℃ |
| TLC | ≥98.0% | >98.0% |
| Optical Purity | <0.30% D-Enantiomer | Zvinoenderana |
| Kujeka Kwemhinduro | 0.3 magiramu mu 2ml DMF Yakajeka Solution | Zvinoenderana |
| Kaiser Test | <0.05% | <0.05% |
| Mvura naKarl Fischer | <0.50% | 0.12% |
| Kurasika paKuomesa | <0.50% (60℃, 2h) | 0.15% |
| Fmoc-β-Ala-OH | <0.20% (HPLC) | Zvinoenderana |
| Fmoc-β-Ala-Leu-OH | <0.10% (HPLC) | Zvinoenderana |
| Fmoc-Leu-Leu-OH | <0.10% (HPLC) | Zvinoenderana |
| Fmoc-Ile-OH | <0.10% (HPLC) | Zvinoenderana |
| Assay Yemahara Amino Acid | <0.20% (GC) | Zvinoenderana |
| Ethyl Acetate | <0.50% (GC) | Zvinoenderana |
| Kuchena / Analysis Method | >99.0% (HPLC) | 99.85% |
| Mass Spectrum | Mukuwirirana Nechiyero | Zvinoenderana |
| NMR Spectrum | Mukuwirirana Nechiyero | Zvinoenderana |
| Mhedziso | Chigadzirwa chacho chakaedzwa uye chinoenderana nezvinodiwa | |
Package: Fluorinated Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma (2~8℃) yekuchengetera kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
Nzira yekuongorora
1. Chitarisiko
-- Visual kuongorora
2. Kuchena (HPLC)
2.1 Chiridzwa
Yakakwira performance liquid chromatography, PDA detector.
Electronic analytical balance
2.2 Reagent
Acetonitrile (chromatographic giredhi), Trifluoroacetic acid (chromatographic giredhi)
2.3 Chromatographic mamiriro
2.3.1 Koramu: YMC-ODS-AM, 5μL, 250x4.6 mm
2.3.2 Kuona wavelength: INC220nm
Kuyerera kweyero: 1.0mL/min
Saizi yemuenzaniso: 10μL (reference)
Diluent: acetonitrile
Nguva yekuunganidza data: 25.00min
2.4 Kugadzirira kwechikamu chenhare
Nharembozha chikamu A (0.1% trifluoroacetic acid mvura): kunyatsotora 2.0ml trifluoroacetic acid, yakasvibiswa nemvura kusvika ku2000ml, sanganisa zvakanaka, uye degassing;
Nharembozha chikamu B (0.1% acetonitrile trifluoroacetic acid): kunyatsotora 2.0ml trifluoroacetic acid, yakasvibiswa kusvika ku2000ml neacetonitrile, kusanganisa uye kubvisa gasi;
Nguva (miniti) A% B%
0.00 90 10
13.00 10 90
18.00 10 90
18.01 90 10
23.00 90 10
2.6 Kugadzirira kwemuenzaniso mhinduro
Weresa uye nyungudutsa 0.1g sampuli ine acetonitrile uye dilute kusvika ku100ml, zunza zvakanaka kuti ushandiswe, kana iwo iwo mafungidziro akafanana.Gadzirira sampuli mbiri dzakafanana.
2.7 Sample Kutsunga
Ongorora sampuli maererano neanotevera sampling maitiro:
Kupfuura jekiseni 1 remhinduro isina chinhu
1 tsono muenzaniso mhinduro 1#
1 tsono muenzaniso mhinduro 2#
2.8 Mhedzisiro Kuverenga
2.8.1 Peak area normalization nzira yakashandiswa kuverenga kuchena kweHPLC nekubvisa nzvimbo isina chinhu.
2.8.2 Iyo hama inoreva kutsauka kwekuchena kwetsono mbiri haifaniri kudarika 1%
2.8.3 Kana mhedzisiro yemajekiseni ese ari maviri akazadzisa maitiro ekugamuchirwa, avhareji yekuchena inotorwa semhedzisiro yekupedzisira.
3, Melting point -- RY-1 melting point chiridzwa
4. Kurasikirwa pakuomesa bvunzo nzira
4.1 Zviridzwa:
Electric thermostatic drying oven, 1/10,000 chiyero.
4.2 Maitiro:
Mubhodhoro rehuremu rakafuratira rine huremu hunoramba huchiwedzera uye kuoma-kuoma kwevhu rakavhara muromo, kuyera 1 gramu (yakarurama kusvika 0.0001 gramu) yemuenzaniso.Sample inofanira kuparadzirwa zvakaenzana pazasi pebhodhoro rekuyeresa nehupamhi husingapfuure 10mm, isa muovheni yekuomesera yemagetsi, yakaoma pa105 ~ 110 ℃ kwemaawa matatu, wozoenda muimba yekuomesa kuti utonhorere. kamuri tembiricha yekuyera.
Kuverenga: Kurasikirwa pakuomeswa %= (M1-M2) ÷M×100
Ikoko: M1: uremu hwemuenzaniso uye bhodhoro rekuyeresa risati raoma, magiramu
M2: uremu hwemuenzaniso uye bhodhoro rekuyeresa mushure mekuoma, mumagiramu
M: Sample uremu, magiramu
5. Kutenderera chaiko
-- Kutenderera chaiko kunoyerwa zvinoenderana neGB/T613-1988
Kugadzirira kwemuenzaniso: 0.5000g sampuli yakayerwa zvakarurama uye yakaendeswa kune yakachena uye yakaoma 50ml volumetric bhodhoro, 20ml DMF yakawedzerwa, bhodhoro rakavharwa uye rakazununguswa kuti riparare, ndokuzoderedzwa kusvika pachiyero neDMF.
Muedzo: Gadzirisa zero yegyroscope isati yaedzwa, wobva waisa chubhu yebvunzo nemhinduro yemuenzaniso, rekodha Angle yekutenderera, uye verenga kutenderera chaiko kwesample neinotevera formula.
[а]D20=(r×50) ÷ (L×W)
[а] D20: Yakananga optical kutenderera pa25 ℃ yemuenzaniso mhinduro
r: Kutenderera kweOptical kunoonekwa pa20 ℃ kune mhinduro yemuenzaniso
50: Vhoriyamu yeyakagadzirirwa sampuli mhinduro (ml)
w: uremu hwemuenzaniso (g)
L: Optical kutenderera chubhu kureba (dm)
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Hazard Symbols Xi - Irritant
Njodzi Makodhi 36/37/38 - Kushungurudza maziso, kufema system uye ganda.
Tsanangudzo Yekuchengetedza S22 - Usafeme guruva.
S24/25 - Dzivisa kusangana neganda nemeso.
S36/37/39 - Pfeka zvipfeko zvekudzivirira zvakakodzera, magurovhosi uye kudzivirira maziso/chiso.
S27 - Bvisa pakarepo zvipfeko zvese zvakasvibiswa.
S26 - Kana wasangana nemaziso, simbura nekukasira nemvura yakawanda uye tsvaga mazano ekurapwa.
WGK Germany 3
HS Code 2922491990
N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) inonzi amino acid derivative inogona kugadzirirwa nekuita kweL-Leucine uye 9-Fluorenomethoxycarbonyl Chloride.
Fmoc-amino acids, inoshandiswa mu peptide synthesis, inoshandiswa se organic synthesis yepakati, pharmaceutical yepakati, biochemical reagent kana kemikari reagent.
Fmoc-L-Leu-OH, inotorwa neamino acid, inoshandiswa mumakemikari epeptide.Yakajairwa chivakwa chekuvaka chenguva yakasimba chikamu peptide synthesis inotevera iyo Fmoc-maitiro.Iyo zvakare imwe yeinoveli PPARγ ligands iyo inogona activate PPARγ nenzira dzakasiyana, iyo inoderedza osteoclasts kusiyanisa, uye nekudaro zviri nani kurapa zvinangwa muchirwere cheshuga pane yechinyakare antidiabetic zvinodhaka.
Kugadzirira 1.05g (0.008 mol) L-Leucine yakasimba inonyungudutswa mu10% sodium carbonate solution, yakamutswa kunyungudutsa zvizere glycine yakasimba, uye 9-fluorene methoxycarbonyl chloride (2.10g, 0.008 mol) mhinduro yakanyungudutswa mu toluene (2~205 ml) inowedzerwa kudonhedza pa20 ~ 30 ℃, kudonhedza kuwedzera kwe30 ~ 60 maminetsi, kupedzisa kudonhedza kuwedzera, kurunga pa20 ~ 30 ℃ kwe1 ~ 8 maawa, wedzera 30-200 ml yemvura kunyungudutsa, uye bvisa nen-butyl. acetate (80 ml) kubvisa yakawandisa 9-fluorene methoxycarbonyl chloride, Iyo inowanikwa aqueous phase is acidified with concentrated hydrochloric acid to PH = 0.5 ~ 3.5, yozobviswa nen-butyl acetate (80 ml), uye chikamu chemafuta chakawanikwa yakashambidzwa nemvura kuti ibvise hydrochloric acid, chikamu chemafuta chakaiswa kuti chibvise n-butyl acetate solvent, makristasi machena akaiswa mvura, akapepetwa uye akaomeswa kuti awane 2.46g yeNα-9-fluorene methoxycarbonyl-L-leucine, ine goho re87.0 %.
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