Gefitinib CAS 184475-35-2 Kuchena > 99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri weGefitinib (CAS: 184475-35-2) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Gefitinib uye yepakati,Please contact: alvin@ruifuchem.com
| Chemical Name | Gefitinib |
| Mashoko anoreva zvakafanana | Gefitinib Free Base;Iressa;ZD1839;ZD-1839;N-(3-Chloro-4-Fluorophenyl) -7-Methoxy-6-(3-Morpholinopropoxy)quinazolin-4-Amine;N-(3-Chloro-4-Fluorophenyl) -7-Methoxy-6-[3-(4-Morpholinyl) propoxy] -4-Quinazolinamine |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 184475-35-2 |
| Molecular Formula | C22H24ClFN4O3 |
| Molecular Weight | 446.91 g/mol |
| Melting Point | 194.0 kusvika 198.0 ℃ |
| Density | 1.322±0.06 g/cm3 |
| Mvura Solubility | Insoluble muMvura |
| Solubility | Soluble muDMSO |
| Storage Temp. | Room Temperature |
| Shipping | Ambient |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Ichena kusvika kuOff-White Powder | Zvinoenderana |
| Kurasika paKuomesa | <0.50% | 0.13% |
| Residue paIgnition | <0.20% | 0.06% |
| Kusachena Kumwechete | <0.10% | 0.09% |
| Zvose Zvisina Kuchena | <0.50% | 0.20% |
| Masimbi anorema (Pb) | ≤10ppm | <10ppm |
| Kuchena / Analysis Method | >99.5% (HPLC) | 99.80% |
| Infrared Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| 1H NMR Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chakaedzwa uye chinoenderana nezvakapihwa | |
Package:Fluorinated Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta muimba inotonhorera, yakaoma uye ine mhepo yakanaka kure nezvinhu zvisingaenderani.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kwete kushandiswa muvanhu.Kwete kushandiswa mukuongorora kana kurapwa.Yekushandisa in vitro research chete.
Hapana kana chimwe chezvigadzirwa chichapihwa kunyika umo izvi zvinogona kupesana nezviripo patents.Nekudaro basa rekupedzisira riri neMutengi.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
| Tsanangudzo Yekuchengetedza | 24/25 - Dzivisa kusangana neganda nemeso. |
| HS Code | 2934999099 |
Gefitinib (CAS: 184475-35-2) inorwisa-tumor yakanangwa yekurapa mushonga wakagadzirwa neAstraZeneca, UK.Ndiwo mushonga wekutanga wakanangana nemorekuru wekurapwa kwegomarara remapapu risiri diki.Inoshanda nekusarudzika inhibiting iyo chiratidzo chekufambisa nzira ye epidermal kukura factor receptor tyrosine kinase (EGFR-TK).Epidermal growth factor (EGF) i polypeptide ine hama molecular mass ye 6.45 × 103, iyo inogona kusanganiswa ne epidermal growth factor receptor (EGFR) pane inonangwa sero membrane kugadzira biological mhedzisiro.EGFR inonzi tyrosine kinase (TK) mhando yekugamuchira.Kana ichisunga kuEGF, inogona kukurudzira kushandiswa kweTK mumuviri wemugamuchiri, zvichiita kuti autophosphorylation ye receptor tyrosine yakasara, ichipa zviratidzo zvinoramba zvichiparadzanisa kumasero, zvichiita kuti masero awedzere uye kusiyanisa.EGFR yakawanda munyama yevanhu uye inoratidzwa zvakanyanya mumamota akaipa.Nekuvhara iyo EGFR yekusaina nzira pane sero pamusoro, gefitinib inotadzisa bundu kukura, metastasis uye angiogenesis, uye inogona kukonzera apoptosis yebundu masero.Muna Nyamavhuvhu 2002, gefitinib yakatanga kutengeswa muJapan semutsetse wekutanga kurapwa kune isiri-diki cell cancer yemapapu pasi pezita rekutengesa Iressa.Muna Chivabvu 2003, iyo US Food and Drug Administration yakabvumidza gefitinib seyechitatu-mutsara monotherapy kune varwere vane yakakwira isiri-diki kenza yemapapu yemapapu avo vaisashanda neplatinum-based anticancer mishonga uye docetaxel chemotherapy.Parizvino, yakatenderwa neAustralia, Japan, Argentina, Singapore neSouth Korea kurapwa kwegomarara remapapu repamusoro risiri diki.Musi waKukadzi 28, 2005, iyo China Chikafu neDrug Administration yakabvumidza gefitinib kurapwa kwepanzvimbo yepamusoro kana metastatic isiri-diki yekenza yemapapu (NSCLC) iyo yakambogamuchira chemotherapy.Izvo hazvisati zvatenderwa kushandiswa seyekutanga-mutsara kurapa kune yepamusoro NSCLC.Musi waChikunguru 1, 2009, European Medicines Agency yakabvumidza zviri pamutemo gefitinib yemutsara wekutanga, yechipiri-mutsara uye yechitatu kurapwa kwenzvimbo yepamusoro kana metastatic isiri diki yekenza yemapapu ine EGFR gene mutations muvakuru.
