Gemcitabine CAS 95058-81-4 Assay 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri weGemcitabine (CAS: 95058-81-4) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Gemcitabine,Please contact: alvin@ruifuchem.com
| Chemical Name | Gemcitabine |
| Mashoko anoreva zvakafanana | 2'-Deoxy-2',2'-Difluorocytidine;4-Amino-1- [3,3-Difluoro-4-Hydroxy-5-(Hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;dFDC;Gemzar (Lilly);LY-188011;dFdCyd;DDFC;2',2'-Difluoro-2'-deoxycytidine;2',2'-Difluorodeoxycytidine;Folfagem;GemLip;Gemcel;Gamcitabine |
| Stock Status | MuStock, Kukwanisa Kugadzira 5 Matani |
| Nhamba yeCAS | 95058-81-4 |
| Inoenderana CAS | 122111-03-9 |
| Molecular Formula | C9H11F2N3O4 |
| Molecular Weight | 263.20 g/mol |
| Melting Point | 217.0 kusvika 222.0 ℃ |
| Density | 1.84±0.10 g/cm3 |
| Sensitive | Heat Sensitive |
| Mvura Solubility | Inoita Insoluble muMvura |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Zvinotsanangurwa | Results |
| Chitarisiko | Hupfu Huchena kana Hunenge Huchena, Husina hwema | Zvinoenderana |
| Cytosine | ≤0.10% | 0.002% |
| α-Isomer | ≤0.10% | 0.01% |
| Kusachena Kwemunhu | ≤0.10% | 0.03% |
| Zvose Zvisina Kuchena | ≤1.00% | 0.10% |
| Mvura naKarl Fischer | ≤1.00% | 0.67% |
| Specific Rotation | +68.0°~+74.0° | +70.5° |
| Heavy Metals | ≤10ppm | <10ppm |
| Residue paIgnition | ≤0.10% | 0.03% |
| Assay (NeHPLC) | 98.0%~102.0% | 99.9% |
| Infrared Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| 1H NMR Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chakaedzwa uye chinoenderana nezvakapihwa | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta muimba inotonhorera, yakaoma uye ine mhepo yakanaka kure nezvinhu zvisingaenderani.Dzivisa kutarisana nezuva rakananga, unyoro uye kupisa kwakanyanya.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Risk Codes R21 - Zvinokuvadza pakubata neganda
R36/38 - Kushungurudza maziso neganda.
R46 - Inogona kukonzera kukuvara kwemajini
R62 - Ngozi inogoneka yekukanganiswa kubereka
R63 - Ngozi inogoneka yekukuvadza kumwana asati azvarwa
Tsanangudzo Yekuchengetedza S25 - Dzivisa kusangana nemeso.
S26 - Kana wasangana nemaziso, simbura nekukasira nemvura yakawanda uye tsvaga mazano ekurapwa.
S36/37 - Pfeka zvipfeko zvekudzivirira zvakakodzera uye magurovhosi.
S53 - Dzivisa kuratidzwa - wana mirairo yakakosha usati washandisa.
HS Code 2934999091
Muchetura LD10 iv mumakonzo: 200 mg/m2 (Abbruzzese)
Gemcitabine (CAS: 95058-81-4) mushonga wechemotherapy unoshandiswa kurapa akati wandei emhando dzegomarara.Izvi zvinosanganisira kenza yemazamu, isiri-diki kenza yemapapu yemasero, kenza yepancreatic, kenza yedundira, uye kenza yebiliary tract.Gemcitabine iri kuferefetwa kuti ishandiswe mugomarara resophageal, uye inoshandiswa kuyedza mumalymphomas nemamwe marudzi akasiyana emamota.Gemcitabine inodzorwa neiyo intravenous nzira, sezvo yakawandisa metabolized ne gastrointestinal turakiti.
Gemcitabine inonzi nucleotide analogue, inova yeboka rinorwisa metabolic remishonga inorwisa cancer.Iyo inonyanya kuita paDNA synthesis phase, kureva, S chikamu.Pasi pemamwe mamiriro, inogona kudzivirira G1 chikamu kubva mukufambira mberi kuenda kuS chikamu.Iyo ine hunhu hweyakakura anticancer spectrum, yakasarudzika nzira yekuita, yakaderera muchetura, hapana kuyambuka-kupikisa kune mamwe chemotherapy mishonga uye hapana superposition yehupfu.Chemicalbook, gemcitabine, yave kutenderwa kushandiswa munyika dzinopfuura makumi mapfumbamwe, zvichiita kuti ive yekutanga-mutsetse kurapwa kune isiri-diki cell kenza yemapapu uye "yegoridhe chiyero" chepancreatic cancer.
Muna 1999, CFDA yakabvumira gemcitabine kurapwa kwepamusoro kana metastatic NSCLC, munharaunda yepamusoro kana metastatic pancreatic cancer;Muna 2010, CChemicalbookFDA yakabvumidza gemcitabine musanganiswa ne paclitaxel kurapwa kweasinga gadziriswe, munharaunda inodzokororwa kana metastatic cancer yemazamu iyo yadzoka mushure me adjuvant/neoadjuvant chemotherapy.
Gemcitabine inonzi wide-spectrum antimetabolite uye deoxycytidine analogue ine antineoplastic chiitiko.Pamusoro pekutonga, gemcitabine inoshandurwa kuita metabolites inoshanda difluorodeoxycytidine diphosphate (dFdCDP) uye difluorodeoxycytidine triphosphate (dFdCTP) ne deoxycytidine kinase.dFdCTP inokwikwidza ne deoxycytidine triphosphate (dCTP) uye inobatanidzwa muDNA.Izvi zvinokiya DNA polymerase nekudaro zvichikonzera kumisa kwakavharwa panguva yekudzokororwa kweDNA.Kune rimwe divi, dFdCDP inhibits ribonucleotide reductase, nokudaro ichideredza deoxynucleotide dziva rinowanikwa reDNA synthesis.Kuderedzwa kweiyo intracellular concentration ye dCTP inogona kuisirwa dFdCTP muDNA.
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