Histamine Dihydrochloride CAS 56-92-8 Assay 98.5~101.0% (Titration) Factory
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri uye mutengesi weHistamine Dihydrochloride (CAS: 56-92-8) ine mhando yepamusoro.Raw materialL-Histidine (H-His-OH) (CAS: 71-00-1)Isu tinokwanisa kupa kuendesa pasirese, zvidiki uye huwandu hwakawanda huripo.Kana iwe uchifarira Histamine Dihydrochloride,Please contact: alvin@ruifuchem.com
Chemical Name | Histamine dihydrochloride |
Mashoko anoreva zvakafanana | Histamine 2HCl;Histamine DiHCl;2-(4-Imidazolyl) ethylamine Dihydrochloride;2-(1H-Imidazol-4-yl) ethylamine Dihydrochloride;2-(1H-Imidazol-4-yl) ethylamine Dihydrochloride;1H-Imidazole-4-ethanamine Dihydrochloride;Ceplene;Peremin |
Stock Status | MuStock, Kukwanisa Kugadzira Matani makumi maviri pamwedzi |
Nhamba yeCAS | 56-92-8 |
Molecular Formula | C5H9N3·2HCl |
Molecular Weight | 184.06 |
Melting Point | 247.0~249.0℃(lit.) |
Density | 1.14 |
Sensitive | Hygroscopic |
Mvura Solubility | Yakanyatso Soluble muMvura, Inenge Yakajeka |
Solubility | Yakanyanya Soluble muMethanol, Soluble muEthanol, Insoluble muEteri |
Storage Temp. | Yakavharwa muKuoma, Chengetedza paChikamu Tembiricha |
COA & MSDS | Available |
Brand | Ruifu Chemical |
Hazard Codes | Xn,Xi | RTECS | MS1575000 |
Risk Statements | 36/37/38-42/43-42-22 | F | 1-8-9 |
Safety Statements | 22-26-36/37/39-45-37-36/37 | TSCA | Ehe |
RIDADR | 3335 | Hazard Kirasi | Irritant |
WGK Germany | 2 | HS Code | 2933990099 |
Items | Kuongorora Maitiro | Results |
Chitarisiko | Makristasi Akachena kana Crystalline Powder | Conforms |
Identification | Infrared Absorption Spectrum | Conforms |
Kuonekwa kweSolution | Pachena | Pass |
Histidine (TLC) | Kwete Kuonekwa | Conforms |
Sulfate (SO4) | ≤0.020% | <0.020% |
Simbi (Fe) | ≤10ppm | <10ppm |
Masimbi anorema (Pb) | ≤10ppm | <10ppm |
Arsenic (As2O3) | ≤10ppm | <10ppm |
Kurasika paKuomesa | ≤0.50% | 0.24% |
Sulfated Ash | ≤0.20% | 0.06% |
Assay | 98.5 kusvika 101.0% (neTitration) | 99.36% |
pH Kukosha | 2.85 kusvika 3.60 (10% aq. Solution) | 3.16 |
Mhedziso | Zvinoenderana neChiyero che AJI97, EP9.0 | |
Main Use | Amino Acids;Zvokudya zvinowedzera;Pharmaceutical Intermediates |
Raw Materials uye Solvents Zvinobatanidzwa muSynthesis process
Raw materials:
L-Histidine (H-His-OH) CAS 71-00-1
Acetophenone CAS 98-86-2
Hydrochloric Acid CAS 7647-01-0
Zvinonyungudutsa
Diethylene Glycol CAS 111-46-6
Ethanol CAS 64-17-5
Isopropyl Doro CAS 67-63-0
Mvura
Histamine Dihydrochloride (CAS: 56-92-8) EP9.0 VhoriyamuⅡTest Method
DEFINITION
Histamine dihydrochloride ine isingasviki 98.5 muzana uye isingapfuure yakaenzana ne101.0 muzana ye2-(1H-imidazol-4-yl) ethan-1-amine dihydrochloride, yakaverengerwa ichitaura nezvechinhu chakaomeswa.
VANHU
Ichena kana inenge chena, crystalline poda kana makristasi asina ruvara, hygroscopic, yakanyanya kunyungudika mumvura, inonyungudika mudoro.
KUZIVA
Kuzivikanwa kwekutanga: A, D.
Chechipiri kuzivikanwa: B, C, D
A. Ongorora ne infrared absorption spectrophotometry (2.2.24), uchienzanisa ne spectrum inowanikwa ne histamine dihydrochloride CRS.Ongorora semadhisiki akagadzirirwa uchishandisa 1 mg yezvinhu.
B. Ongorora machromatograms akawanikwa mukuedzwa kwehistidine.Nzvimbo huru muchromatogram yakawanikwa nebvunzo mhinduro (b) yakafanana pachinzvimbo, ruvara uye saizi kune yakakosha nzvimbo muchromatogram yakawanikwa nereferensi mhinduro (a).
C. Dissolve 0.1 g mu7 mL yemvura R wowedzera 3 mL ye200 g/L solution ye sodium hydroxide R. Dissolve 50mg ye sulfanilic acid R mumusanganiswa we 0.1 mL yehydrochloric acid R uye 10 mL yemvura R uye wedzera 0.1 mL ye sodium nitrite solution R. Wedzera mhinduro yechipiri kune yekutanga uye sanganisa.Ruvara rutsvuku runogadzirwa.
D. Inopa kuita (a) kwekloridi (2.3.1).
ZVIYEDZO
Solution S. Dissolve 0.5g mumvura isina carbon dioxide-isina R yakagadzirwa kubva mumvura yakasvibiswa R uye inonatsa kusvika ku10 mL neine solvent yakafanana.
Kuonekwa kwemhinduro.Solution S yakajeka (2.2.1) uye haina kunyanya kupenya kupfuura referensi mhinduro Y7 (2.2.2, Method II).
pH (2.2.3).Iyo pH yemhinduro S ndeye 2.85 kusvika 3.60.
Histidine.Ongorora neyakaonda-layer chromatography (2.2.27), uchishandisa TLC silica gel G ndiro R.
Muedzo mhinduro (a).Dissolve 0.5g yechinhu chinofanirwa kuongororwa mumvura R uye diluted kusvika ku10 mL neine solvent yakafanana.
Mhinduro yekuedza (b).Dilute 2 mL yebvunzo mhinduro (a) kusvika 10 mL nemvura R.
Reference solution (a).Dissolve 0.1 g ye histamine dihydrochloride CRS mumvura R uye dilute kusvika ku10 mL neine solvent yakafanana.
Reference solution (b).Dissolve 50 mg ye histidine monohydrochloride R mumvura R uye shandura kusvika ku100 mL neine solvent yakafanana.
Reference solution (c).Sanganisa 1 mL yebvunzo mhinduro (a) uye 1 mL yereferensi mhinduro (b).
Isa kuplate 1 μL yemhinduro yebvunzo (a), 1 μL yemhinduro yebvunzo (b), 1 μL yereferensi mhinduro (a), 1 μL yereferensi mhinduro (b) uye 2 μL yereferensi mhinduro (c).Gadzira pamusoro penzira ye15cm uchishandisa musanganiswa we5volumes ye concentrated ammonia R, 20 mavhoriyamu emvura R uye 75 mavhoriyamu eacetonitrile R. Pukuta ndiro mumhepo yazvino.Dzokorora kusimudzira munzira imwechete, omesa ndiro mumhepo yemhepo uye pfapfaidza ine ninhydrin mhinduro R1.Pisa ndiro pa 110 ° C kwemaminitsi gumi.Chero nzvimbo inoenderana nehistidine muchromatogram inowanikwa nebvunzo mhinduro (a) haina kusimba kupfuura nzvimbo iri muchromatogram yakawanikwa nereferensi mhinduro (b) (1 muzana).Muedzo haushande kunze kwekunge chromatogram yakawanikwa ine referensi mhinduro (c) inoratidza 2 nzvimbo dzakapatsanurwa zvakajeka.
Sulfates (2.4.13).3mL yemushonga S yakanyungudutswa kusvika pa15 mL nemvura yakanyungudutswa R inopindirana nemuyedzo wemuganho wesarufa (0.1 muzana).
Kurasikirwa pakuomeswa (2.2.32).Kwete kupfuura 0.5 muzana, yakatemwa pa 0.20 g nekuomesa muovheni pa105 ° C.
Sulfated ash (2.4.14).Kwete kupfuura 0.1 muzana, yakatarwa pa 0.5 g.
ASSAY
Dissolve 0.080 g mumusanganiswa we 5.0 mL we0.01 M hydrochloric acid uye 50 mL yedoro R. Ita potentiometric titration (2.2.20), uchishandisa0.1 M sodium hydroxide.Verenga vhoriyamu yakawedzerwa pakati pekutanga neyechitatu mapoinzi einflexion.
1mL ye0.1 M sodium hydroxide yakaenzana ne9.203 mg yeC5H11Cl2N3.
STORAGE
Chengetedza mumudziyo usina mhepo, wakachengetedzwa kubva pachiedza.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
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Kushandiswa kweHistamine Dihydrochloride (CAS: 56-92-8)
1. Histamine Dihydrochloride yakaratidzwa kuti iite nitric oxide synthetase uye kudzvinyirira kana kudzivisa chizvarwa cheiyo reactive oxygen marudzi (ROS).Inhibition yeROS neHistamine Dihydrochloride inobvumira kushandiswa kweT masero uye NK masero neIL-2.Mumuenzaniso wemakonzo, histamine dihydrochloride yakadzvanya ROS yakagadzirwa neKupffer maseru kuburikidza neH2 histamine receptor.Iyo ine simba vasodilator uye endogenous histamine receptor agonist.
2. Histamine Dihydrochloride (zita rekutengesa Ceplene) munyu weHistamine unoshandiswa semushonga wekudzivirira kudzoka zvakare kune varwere vanoonekwa kuti vane acute myeloid leukemia (AML).
Iyo FDA inotenderwa inoshanda chimedu che topical analgesic kushandiswa uye inowanikwa muzvigadzirwa zvakaita seAustralia Dream Cream, iyo inoshandiswa kuzorodza kwechinguva diki marwadzo uye marwadzo emhasuru uye majoini ane hukama nearthritis, nyore musana, mavanga, sprains, uye. strains.
3. Histamine Dihydrochloride inoshandiswa pakuregererwa kwakasimba nekudzivirira kudzoka zvakare kune varwere vakura vane acute myeloid leukemia (AML) mushure mekutanga kurapwa.Mushonga unoderedza kugadzirwa kwemapoka eokisijeni ne autophagocytes, inhibits nicotinamide adenine dichemicalbo phosphate oxidase uye inodzivirira interleukin-2 kubva pakuita NK masero uye T masero.Histamine Dihydrochloride jekiseni rakatenderwa pahwaro hwekuti kuregererwa kwayo kwakazara pamwe chete ne interleukin-2 zvakanyanya kuderedzwa kudzokazve muvarwere veAM.