N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Yepakati Yakanyanya Kuchena
Commerce Supply Imatinib Mesylate uye Related Intermediates:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Chemical Name | N-(5-Amino-2-methylphenyl) -4-(3-pyridyl) -2-pyrimidinea |
| Mashoko anoreva zvakafanana | Imatinib Mesylate Intermediate;2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine |
| Nhamba yeCAS | 152460-10-1 |
| Nhamba yeCAT | RF-PI230 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C16H15N5 |
| Molecular Weight | 277.32 |
| Melting Point | 133.0-135.0℃ |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Chiedza cheOrenji kuenda kuYero Powder kuenda kuCrystal |
| Kuchena / Analysis Method | ≥98.0% |
| Kurasika paKuomesa | ≤0.50% |
| Residue pamoto | ≤0.50% |
| Zvose Zvisina Kuchena | ≤2.0% |
| Maximum Single Kusachena | ≤1.0% |
| Heavy Metals | ≤20ppm |
| Test Standard | Enterprise Standard |
| Usage | Pakati peImatinib Mesylate (CAS: 220127-57-1) |
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
Shanghai Ruifu Chemical Co., Ltd ndiyo inotungamira mugadziri uye mugovera weN-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) ine mhando yepamusoro. .
N-(5-Amino-2-methylphenyl) -4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) iri pakati kazhinji mukugadzirwa kweImatinib Mesylate (CAS: 220127-57-1) API.
Imatinib mesylate imorekuru diki rinodzivirira c-Abl protein-tyrosine kinase, kinase inonyanya kukosha pakupararira kwechronic myelogenous leukemia (CML).Chiitiko chekufambisa pakati pemakromosomes 9 ne22 chinoburitsa chromosome yePhiladelphia, iyo inobva yagadzira Bcr-Abl fusion protein ine aberrant kinase chiitiko chinosimudzira kukurumidza kuwanda kwesero.Imatinib mesylate inosunga iyi yakakosha kinase, inomisa CML ine chekuita nekukura.Imatinib mesylate yakaramba ichiratidzwa kuti inhibit PDGFR uye tyrosine kinases yakabatana ne c-Kit.Magadzirirwo ane Imatinib mesylate akashandiswa mukurapa kwakasiyana kenza.
Imatinib mesylate is A tyrosine kinase inhibitor.Yakanyanya kutsanangurwa yeBCR-ABL, iyo enzyme inosanganiswa neasingaperi myelogenous leukemia (CML) uye mamwe mafomu eacute lymphoblastic leukemia (ALL).Iyo ine simba uye inosarudza v-Abl tyrosine kinase inhibitor (IC50 = 38 nM).Zvakare inhibits PDGFR uye c-kit.Inoratidza kusarudza kwev-Abl pamusoro peimwe tyrosine uye serine/threonine protein kinases.Inosarudza inodzivisa PDGF-inosimudzira kukura kwev-abl-yakashandurwa PB-3 masero uye v-sis-yakashandurwa BALB / c 3T3 masero mu vitro.Inoratidza antitumor mhedzisiro mumakonzo ane AMuLV kana BABL/c 3T3 v-sis masero.Inodzivisa kudzokorora kweSARS-CoV uye MERS-CoV in vitro (EC50 kukosha ndeye 9.823 uye 17.689 μM, zvichiteerana).
![4--[(4-Methylpiperazin-1-yl) methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Yepakati Yakanyanya Kuchena](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)