Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory High Quality
Commerce Supply Imatinib Mesylate uye Related Intermediates:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Chemical Name | Imatinib Mesylate (alpha fomu) |
| Mashoko anoreva zvakafanana | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
| Nhamba yeCAS | 220127-57-1 |
| Nhamba yeCAT | RF-API19 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C30H35N7O4S |
| Molecular Weight | 589.71 |
| Shipping Condition | Under Ambient Temperature |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Ichena kusvika kuOff-White Crystalline Powder |
| Solubility | Nyore kunyungudika mumvura |
| HPLC Kuzivikanwa | Sample spectrum main peak retention nguva inoenderana nazvo |
| IR Identification | Infrared absorption spectrum yemuenzaniso inoenderana nereferenzi sampuli |
| Melting Point | 214.0~222.0℃ |
| Kurasika paKuomesa | ≤0.50% |
| Residue paIgnition | ≤0.10% |
| Heavy Metals | ≤20ppm |
| Related Substances | (1) Kusachena G: NMT 0.3% |
| (2) Kusachena B: NMT 0.3% | |
| (3) Kusachena C: NMT 0.3% | |
| (4) Kusachena D: NMT 0.3% | |
| (5) Kusachena A: NMT 0.3% | |
| (6) Kusachena H: NMT 0.3% | |
| (7) Kusachena F: NMT 0.3% | |
| (8) Kusachena E: NMT 0.3% | |
| (9) Kusachena kukuru kumwechete: NMT0.1% | |
| Residual Solvents | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| HPLC Kuongorora | 98.0% ~ 102.0% (C30H35N7SO4 Yakaverengerwa paAnhydrous Basis) |
| Test Standard | Enterprise Standard |
| Usage | API;Ph+CML |
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
Imatinib Mesylate(CAS 220127-57-1) imorekuru diki rinovharira c-Abl protein-tyrosine kinase, kinase inonyanya kukosha pakuwanda kwechirwere chisingaperi myelogenous leukemia (CML).Yakanyanya kutsanangurwa yeBCR-ABL, iyo enzyme inosanganiswa neasingaperi myelogenous leukemia (CML) uye mamwe mafomu eacute lymphoblastic leukemia (ALL).Iyo ine simba uye inosarudza v-Abl tyrosine kinase inhibitor (IC50 = 38 nM).Chiitiko chekufambisa pakati pemakromosomes 9 ne22 chinoburitsa chromosome yePhiladelphia, iyo inobva yagadzira Bcr-Abl fusion protein ine aberrant kinase chiitiko chinosimudzira kukurumidza kuwanda kwesero.Imatinib mesylate inosunga iyi yakakosha kinase, inomisa CML ine chekuita nekukura.Imatinib mesylate yakaramba ichiratidzwa kuti inhibit PDGFR uye tyrosine kinases yakabatana ne c-Kit.
![4--[(4-Methylpiperazin-1-yl) methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Yepakati Yakanyanya Kuchena](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)