Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity
Manufacturer Supply Irinotecan uye Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Yemahara Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Chemical Name | Irinotecan Hydrochloride |
| Mashoko anoreva zvakafanana | Camptothecin II;CPT-II |
| Nhamba yeCAS | 100286-90-6 |
| Nhamba yeCAT | RF-API50 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C33H39ClN4O6 |
| Molecular Weight | 623.15 |
| Melting Point | 250-256 ℃ (Zvita) |
| Storage Conditions | Under Ambient Temperature |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | White kana Off-White Powder |
| Solubility | Soluble mumvura uye methanol, zvishoma soluble mu chloroform, ethanol |
| Kuzivikanwa IR | Iyo infrared absorption spectrum yemuyedzo sampuli inofanirwa kuenderana neiyo yereference standard |
| Kuzivikanwa HPLC | Nguva yekuchengeta yenhongonya huru yemuenzaniso mhinduro inofanirwa kuenderana neiyo yereferensi mwero. |
| Identification | Inosangana nezvinodiwa zvebvunzo dzeChloride Positive reaction |
| Kunyorova (KF) | 7.0%~9.0% w/w |
| Residue paIgnition | ≤0.10% |
| Heavy Metals | ≤20ppm |
| Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desethyl Irinotecan | ≤0.15% |
| Irinotecan Related Compound A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| Camptothecin | ≤0.15% |
| Irinotecan Related Compound B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| Chero Kusachena Kusina Kutaurwa | ≤0.10% |
| Zvose Zvisina Kuchena | ≤0.50% |
| Residual Solvents (GC) | |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤500ppm |
| Peteoleum Ether: | ≤100ppm |
| Ethyl Acetate | ≤2000ppm |
| Benzene | ≤2ppm |
| Bacterial Endotoxins | ≤0.29 EU/mg Irinotecan |
| Microbial Limits | Total Aerobic Microbial Count: <1000 cfu/g |
| Molds uye Mbiriso | <100 cfu/g |
| Kuchena / Analysis Method | ≥99.0% (HPLC, pane anhydrous basis) |
| Test Standard | United States Pharmacopeia (USP) Standard |
| Usage | Active Pharmaceutical Ingredient (API) |
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
lrinotecan hydrochloride (CAS 100286-90-6), semi-synthetic, mvura inonyungudika inobva kune ine simba anticancer agent camptothecin, yakatangwa muJapan kurapwa kwemapapu, ovarian, uye cervical cancer.lrinotecan inoshandisa basa rayo rekudzivirira kuburikidza nekudzivisa topoisomerase I, cellular enzyme inobatanidzwa mukuchengeta topographic chimiro cheDNA panguva yekushandura, kunyora, uye mitosis.lrinotecan inoitwa de-esterification mu vivo kuti ibudise inoshanda metabolite, SN-38, iyo ine simba rakapetwa ka1000 kupfuura mubereki.Combination therapy yeirinotecan neimwe inonyanya kushandiswa anticancer agent, cisplatin, inonzi inopfuura chero mumiririri oga.lrinotecan iri mumakiriniki ekuedzwa kwegastrointestinal, zamu, ganda, colorectal, pancreatic cancers, mesothelioma uye isiri-Hodgkin's lymphoma.
