Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Factory High Purity
Manufacturer Supply Irinotecan uye Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Yemahara Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Chemical Name | Irinotecan Hydrochloride Trihydrate |
| Mashoko anoreva zvakafanana | Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Irinotecan HCL 3H2O |
| Nhamba yeCAS | 136572-09-3 |
| Nhamba yeCAT | RF-API52 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C33H38N4O6·HCl·3H2O |
| Molecular Weight | 677.20 |
| Melting Point | 250.0~256.0℃ (Zvita) |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Yero Yero kana Yellow Crystalline Powder |
| Assay (w/w) | 98.0%~102.0% |
| Kuchena (HPLC) | ≥99.5% |
| Solubility | Zvishoma kunyungudika mumvura, ethanol kana chloroform, Inoita Insoluble muacetone |
| Identification | neIR uye HPLC, Inopindirana |
| Specific Optical Rotation | +60°~+73° |
| Mvura | 7.0%~9.0% |
| Zvisaririra zvezvinonyungudutsa | Inoenderana neICH Zvinodiwa |
| Residue paIgnition | ≤0.20% |
| Chloride | 5.0%~6.0% |
| pH Kukosha | 3.0~5.0 |
| Heavy Metals | ≤20ppm |
| Kusachena Kwemunhu | ≤0.10% |
| Zvose Zvisina Kuchena | ≤0.50% |
| Storage Condition | Chengetedza pa2-8 ° C, Mumidziyo yakavharwa uye chengetedza kubva kuchiedza uye unyoro |
| Test Standard | Enterprise Standard |
| Usage | Active Pharmaceutical Ingredient (API) |
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri uye mutengesi weIrinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) ine mhando yepamusoro.
Irinotecan Hydrochloride Trihydrate is topoisomerase I inhibitor inonyanya kushandiswa kurapa gomarara rekoloni uye rectal cancer, kudzivirira kuvimbika kweiyo DNA strand nekusunga topoisomerase I-DNA yakaoma.lrinotecan hydrochloride, semi-synthetic, mvura inonyungudika kubva kune ine simba anticancer agent camptothecin, yakatangwa muJapan kurapa kenza dzemapapu, ovarian, uye cervical.lrinotecan inoshandisa basa rayo rekudzivirira kuburikidza nekudzivisa topoisomerase I, cellular enzyme inobatanidzwa mukuchengeta topographic chimiro cheDNA panguva yekushandura, kunyora, uye mitosis.lrinotecan inoitwa de-esterification mu vivo kuti ibudise inoshanda metabolite, SN-38, iyo ine simba rakapetwa ka1000 kupfuura mubereki.Kunyange zvazvo iri muchetura zvishoma kudarika camptothecin, nhamba inokosha yevarwere mumakiriniki ekuedzwa yakaratidza migumisiro yeleukopenia, manyoka, nauseahromiting, uye alopecia.Combination therapy yeirinotecan neimwe inonyanya kushandiswa anticancer agent, cisplatin, inonzi inopfuura chero mumiririri oga.lrinotecan iri mumakiriniki ekuedzwa kwegastrointestinal, zamu, ganda, colorectal, pancreatic cancers, mesothelioma uye isiri-Hodgkin's lymphoma.
