Ketorolac CAS 74103-06-3 Kuchena > 98.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira Ketorolac (CAS: 74103-06-3) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, madiki uye akawanda akawanda aripo.Tenga Ketorolac,Please contact: alvin@ruifuchem.com
| Chemical Name | Ketorolac |
| Mashoko anoreva zvakafanana | 5-Benzoyl-2,3-Dihydro-1H-Pyrrolizine-1-Carboxylic Acid;5-Benzoyl-2,3-Dihydro-1h-Pyrrolo[1,2-a]pyrrole-1-Carboxylic Acid;(±)-Ketorolac;Acular LS;Keromin;rac Ketorolac;Toradol |
| Stock Status | Mudura |
| Nhamba yeCAS | 74103-06-3 |
| Molecular Formula | C15H13NO3 |
| Molecular Weight | 255.27 g/mol |
| Melting Point | 159.0~161.0℃ |
| Density | 1.33±0.10 g/cm3 |
| Storage Temp. | Nzvimbo Inotonhorera & Yakaoma (2~8℃) |
| COA & MSDS | Available |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Off-White Crystalline Powder | Zvinoenderana |
| Melting Point | 159.0~161.0℃ | 159.5 ℃ |
| Kurasika paKuomesa | <0.50% | 0.2% |
| Residue paIgnition | <0.10% | 0.062% |
| Max.Kusachena Kumwechete | <1.00% | 0.48% |
| Heavy Metals (as Pb) | ≤10ppm | 6ppm |
| Kuchena / Analysis Method | >98.5% (HPLC) | 99.0% |
| Proton NMR Spectrum | Inopindirana neChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chacho chakaedzwa uye chinoenderana nezvinodiwa | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumudziyo wakavharwa zvakasimba.Chengetedza munzvimbo inotonhorera, yakaoma (2 ~ 8 ℃) uye ine mhepo yakanaka yekuchengetera kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
RIDADR 3249
Kirasi yeNjodzi 6.1(a)
PackingGroup II
HS Code 2933998090
Toxicity LD50 nemuromo mumakonzo: ~ 200 mg/kg (Rooks)
Ketorolac (CAS: 74103-06-3) isiri steroid analgesic uye anti-inflammatory drug, inobva kune pyrrolidone.Makemikari maitiro uye pharmacological action yakafanana neTolectin, Zoaesthetic acid uye Indometacin.Nekudzivisa cyclooxygenase, inhibits synthesis uye kusunungurwa kweprostaglandin, uye inogadzira anti-inflammatory effects.Inogona kuderedza tembiricha inokonzerwa nekupisa sosi, iyo inoenderana nekudzivirirwa kweiyo prostaglandin synthesis yepakati tsinga system.Iine yakasimba analgesic uye ine mwero anti-inflammatory antipyretic uye inhibition yeplatelet aggregation, uye haina inhibition yekufema uye. kupindwa muropa.Mukuedza kwemhuka, analgesic effect yakasimba kudarika aspirin, indomethacin uye naproxen. Yakaenzana kana nani kudarika anti-inflammatory effect ye naproxen uye indomethacin, phenylbutazone, antipyretic effect pamakonzo yakasimba kudarika aspirin ne phenylbutazone uye zvakafanana ne indomethacin uye naproxen.Inodzivisa kusanganiswa kweplatelet kunokonzerwa nearachidonic acid uye collagen.Asi hazvidziviriri kuiswa kweadenosine diphosphate (ADP).Ichi chigadzirwa chinokurumidza uye chakanyatsogadziriswa mushure mejojo ye intramuscular, uye inenge yakanyatsogadziriswa mushure mekutonga kwemuromo.Zvokudya zvinogona kuderedza kukurumidza kutora, asi hazvibatsiri dhigirii yekutora, uye bioavailability ndeye 80% ~ 100%.Maminitsi gumi mushure mejekiseni re intramuscular ye 30mg, inowanzobvisa marwadzo pachena.Mushure memaminitsi makumi mashanu, nhamba yepamusoro yeplasma inokwira kusvika 2.2 g/mL.Mushure me30 ~ 60 maminetsi ekutungamirirwa nemuromo, marwadzo ari pachena akasunungurwa uye kuiswa kweplasma kunowedzera pa 1.5 kusvika kumaawa mana.Iyo plasma hafu yehupenyu hwevechidiki inenge maawa 5.3, uye kune vakwegura inenge maawa manomwe, uye analgesic effect inogona kuchengetwa kwe6 ~ 8 maawa.91.4% ichave yakasvibiswa kubva pamucheka weti, iyo yose ichabviswa kubva kune tsvina.Muvarwere vane renal insufficiency, iyo yose yeplasma clearance rate inoderera uye hafu yeupenyu inowedzera, saka chiyero chinofanira kuderedzwa.
Clinical application: Ketorolac inonyanya kushandiswa pakurapa kurwadziwa kwenguva pfupi kunosanganisira kurwadziwa kwepashure (senge dumbu, chipfuva, Urology, gynecology, Dhipatimendi reStomatology, kuvhiyiwa kwemapfupa uye kurwadziwa) pamwe nekurwadziwa kweskeletal tsandanyama kunokonzerwa nezvikonzero zvakasiyana-siyana, zvakadai se sprain, dislocation, fracture uye soft tissue kukuvara, uye mamwe marwadzo anokonzerwa nezvimwe zvirwere, zvakadai sekurwadziwa kwepashure, acute renal colic, toothache, sciatica, kurwadziwa kwekenza yekupedzisira, kurwadziwa kweronda, biliary colic, nezvimwewo. Inogona kushandiswa sechinotsiva morphine uye pethidine.
