L-4-Nitrophenylalanine Methyl Ester HCl CAS 17193-40-7 H-Phe(4-NO2)-OMe·HCl Assay >98.5% (HPLC) Factory
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri uye mutengesi weL-4-Nitrophenylalanine Methyl Ester HCl (H-Phe(4-NO2)-OMe·HCl) (CAS: 17193-40-7) ine mhando yepamusoro.Ruifu Chemical inopa akateedzana amino acids uye zvinobva.Isu tinokwanisa kupa kuendesa pasirese, zvidiki uye huwandu hwakawanda huripo.Kana uchida L-4-Nitrophenylalanine Methyl Ester HCl,Please contact: alvin@ruifuchem.com
| Chemical Name | L-4-Nitrophenylalanine Methyl Ester HCl |
| Mashoko anoreva zvakafanana | H-Phe(4-NO2)-OMe·HCl;Hp-Nitro-Phe-OMe·HCl;L-Phe(4-NO2)-OMe·HCl;p-Nitro-L-Phe-OMe·HCl;L-4-NO2-Phe-OMe·HCl;L-4-Nitrophenylalanine Methyl Ester Hydrochloride;4-Nitro-L-Phenylalanine Methyl Ester Hydrochloride;p-Nitrophenylalanine Methyl Ester Hydrochloride;Methyl 4-Nitro-L-Phenylalaninate Hydrochloride;(S)-(+)-4-Nitrophenylalanine Methyl Ester Hydrochloride |
| Stock Status | MuStock, Kukwanisa Kugadzira Matani makumi maviri pamwedzi |
| Nhamba yeCAS | 17193-40-7 |
| Molecular Formula | C10H12N2O4·HCl |
| Molecular Weight | 260.67 |
| Melting Point | 225.0~235.0℃ |
| Storage Temp. | Yakavharwa muKuoma, Chengetedza paChikamu Tembiricha |
| COA & MSDS | Available |
| Classification | Amino Acids & Derivatives |
| Brand | Ruifu Chemical |
| Risk Statements | 22-43-36 | Hazard Kirasi | 6.1 |
| Safety Statements | 22-36/37-24/25 | Packing Group | III |
| RIDADR | 2811 | HS Code | 2922491990 |
| WGK Germany | 3 |
| Items | Kuongorora Maitiro | Results |
| Tsanangudzo | Off-White kusvika Pale Yellow Powder | Conforms |
| Kuzivikanwa neHPLC | Iyo nguva yekuchengeta yepamusoro peak muchromatogram yekugadzirira bvunzo inoenderana neiyo iri muchromatogram yegadziriro yekukodzera praparation sezvakawanikwa mukuchena kwechromatographic uye kusvibiswa neHPLC. | Conforms |
| Kutenderera kwakananga [α]20/D | +20.0 kusvika +24.0° (C=1, MeOH) | +22.4° |
| Melting Point | 225.0~235.0℃ | 227.0~230.0℃ |
| Kurasika paKuomesa | <0.50% (pa105℃ kwe3 Maawa) | 0.23% |
| Residue paIgnition | <0.10% | 0.06% |
| Assay / Analysis Method | >98.5% (neHPLC) | 98.75% |
| Enantiomer Content | <0.15% (neHPLC) | 0.09% |
| 4-Nitro-L-Phenylalanine | <1.50% (neHPLC) | 0.91% |
| Zvose Zvisina Kuchena | <1.50% (neHPLC) | 1.25% |
| Mhedziso | Ichi Chigadzirwa neKuongorora Zvibvumirano neiyo Enterprise Standard | |
| Sherufu Hupenyu | Mwedzi 24 Mupakeji Yayo Yekutanga Kana Yakachengetwa Zvakanaka | |
| Main Use | Pharmaceutical Intermediates;Zolmitriptan Pakati | |
Package: Fluorinated Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera, yakaoma uye inofefetera kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
Nzira Yekuongorora yeL-4-Nitrophenylalanine Methyl Ester HCl (H-Phe(4-NO2)-OMe·HCl) (CAS: 17193-40-7)
Tsanangudzo: Isa inenge 2 g yesampuli mune yakachena uye yakaoma petri-ndiro uye tarisa kutaridzika kwemuenzaniso.Kushuma: Taura zvakaonekwa
Identificaiton: Enzanisa nguva yekuchengeta yenhongonya huru muchromatogram yegadziriro yebvunzo nenguva yekuchengeta yepamusoro peak muchromatogram yekukodzera system praparation sezvakawanikwa mukuchena kwechromatographic neHPLC.
Kurasikirwa Pakuomesa: Pukuta girazi-rakamiswa, bhodhoro rehuremu risina kudzika pa105±2℃ kwemaminetsi makumi matatu.Bvumira kuti itonhorere kusvika kukamuri tembiricha mune desciccator.Wera nemazvo bhodhoro rekuyeresa nechimiso uye rekodha huremu (W1).Chinja nezve 1 kusvika 2g yakanyatso kuyerwa huwandu hweyedzo mubhodhoro rekuyeresa.Nekuzunza zvinyoro-nyoro, nepadivi, govera sampuli yebvunzo zvakaenzana sezvinobvira kusvika pakadzika hunosvika 5 mm.Weresa bhodhoro rekuyeresa rakaremerwa uye nyora huremu (W2).Isa bhodhoro rakatakurwa muchoto chekuomesa, kubvisa chivharo uye kuchisiya zvakare mukamuri.Pukuta bvunzo pa105±2℃ kwemaawa matatu.Pakuvhura kamuri, vhara bhodhoro nekukasira, uye ribvumire kuti riuye kune tembiricha yekamuri mune desiccator.Weresa nemazvo bhodhoro rekuyeresa nechimiso uye wodzora huremu (W3).Verenga kurasikirwa kwezana pakuomeswa kwemuenzaniso uchishandisa fomura inotevera:
Kuverenga Kurasika pakuomeswa (% w/w)= (W2-W3) ÷ (W2-W1) x 100
Enantiomer Zvemukati neHPLC:
Chemical & Reagents:
n-Hexane AR giredhi
Methanol HPLC giredhi
Isopropyl Doro HPLC giredhi
Diethylamine AR giredhi
Mitemo: L-4-Nitrophenylalanine Methyl Ester HCl muyero;L-4-Nitrophenylalanine Methyl Ester HCl enantiomer mwero
Nharembozha: Gadzirira musanganiswa wakakwana wen-Hexane, Isopropyl Doro, Methanol uye Diethylamine (65:20:15:0.1 v/v/v/v)
Kugadzirira Kusina Kurongeka: Shandura 2.5ml yeMethanol mu10-ml volumetric flask, wedzera kuvhoriyamu nechikamu chenhare uye sanganisa.
Kugadzirira kunokodzera sisitimu:
Yeresa nemazvo uye woendesa inenge 5 mg imwe neimwe yeL-4-Nitrophenylalanine Methyl Ester HCl yakajairwa uye L-4-Nitrophenylalanine Methyl Ester HCl enantiomer mwero mu 10-ml volumetric flask, inonyungudika munenge 2.5ml yemethanol, diluted to volume with mobile phone chikamu uye sanganisa.
Kugadzirira bvunzo:
Weresa nemazvo uye wotamisa nezve 5 mg yesampuli mu 10-mol volumetric flask, nyungudika munenge 2.5ml yemethanol, wedzera kuvhoriyamu ne mobile phase uye sanganisa.
Instrumental parameters:
Chiridzwa: HPLC ine jekiseni, Pombi, UV detector uye Recorder
Column: ChiralPak-IC (4.6mm x 250mm) 5 μ kana zvakaenzana
Kuyerera: 1.0 ml / miniti
Wavelength: 260nm
Jekiseni vhoriyamu: 10 μL
Tembiricha yeColumn Coven: 25 ℃
Nguva yekumhanya: maminitsi makumi maviri
Maitiro
Jekiseni zvigadziriso sezvakataurwa munhevedzano inotevera.Rekodha machromatogram uye simbisa maitiro:
Tsanangudzo Yemajekiseni Nhamba Yemajekiseni Criteria
Kugadzirira Kusina 1 Hapana kupindira kwepamusoro kunofanira kuonekwa panguva yekuchengetedza L-4-Nitrophenylalanine Methyl Ester HCl kana enantiomer.
Kugadzirira kweSistimu yakakodzera 1 Kugadziriswa pakati peL-4-Nitrophenylalanine Methyl Ester HCl uye peak enantiomer haifanirwe kunge isingasviki 2.0
Kugadzirira bvunzo 1 Shandisa test chromatogram kuona enantiomer zvirimo mumuenzaniso.
Nguva dzekuchengeta:
L-4-Nitrophenylalanine Methyl Ester HCl 1.0
Enantiomer Nezve 1.11
Nguva yekuchengetedza yeL-4-Nitrophenylalanine Methyl Ester HCl inenge maminitsi 9.8.
Kuverengera: Muchromatogram yakawanikwa kubva mukugadzirira bvunzo, regedza ese mapikisi anotarisira L-4-Nitrophenylalanine Methyl Ester HCl neEnantiomer.Rondedzera iyo enantiomer zvirimo mumuenzaniso nenharaunda normalization nzira.
Chromatogrpahic Kuchena uye Kusvibiswa neHPLC:
Chemical & Reagents:
Diammonium phosphate AR giredhi
Phosphoric acid AR giredhi
Methanol HPLC giredhi
Mvura Yakanatswa
Mitemo
L-4-Nitrophenylalanine Methyl Ester HCl chiyero
4-Nitro-L-Phenylalanine monohydrate chiyero
Mobile Phase-A
Dissolve 6.6 g yeDiammonium phosphate mu 1000ml yemvura yakanatswa.Gadzirisa pH yemhinduro iyi kusvika pa6.0 nePhosphoric acid.Sefa uye degas.Usati wayera pH yemushonga, ruramisa pH mita neyakajairwa buffer solution pH 4.01 UYE 7.00.
Mobile Phase-B
Methanol HPLC giredhi
Kugadzirira Kukodzera Kwehurongwa
Weresa nemazvo uye wotamisa nezve 25 mg imwe neimwe yeL-4-Nitrophenylalanine Methyl Ester HCl yakajairwa uye 4-Nitro-L-Phenylalanine monohydrate standard mu50-ml volumetric flask, nyungudika uye diluted kusvika kuhuwandu nemethanol uye sanganisa.
Kugadzirira Muedzo:
Weresa nemazvo uye wotamisa nezve 25 mg sampuli mu50-ml volumetric flask, nyungudika mukati uye wedzera kuhuwandu nemethanol uye sanganisa.
Instrumental parameters:
Chiridzwa: HPLC ine jekiseni, Pombi, UV detector uye Recorder
Column: XTerra RP-18 (4.6mm x 150mm) 5 μ kana zvakaenzana
Kuyerera: 1.0 ml / miniti
Wavelength: 265nm
Jekiseni vhoriyamu: 20 μL
Tembiricha yeColumn Coven: 25 ℃
Nguva yekumhanya: 45 maminitsi
Gradient Chirongwa
Nguva (min) Mobile Phase-A % Mobile Phase-B %
0.01 90 10
15 60 40
35 40 60
40 35 65
41 90 10
45 90 10
Maitiro:
Jekiseni zvigadziriso sezvakataurwa munhevedzano inotevera.Rekodha machromatogram uye simbisa maitiro:
Kugadzirira Kusina 1 Hapana kupindira kwepamusoro kunofanira kuonekwa panguva yekuchengetedza L-4-Nitrophenylalanine Methyl Ester HCl.
Kugadzirira kweSistimu yekukodzera 1 Tailing factor yeL-4-Nitrophenylalanine Methyl Ester HCl peak haifanirwe kunge iri pasi pe2.0
Kugadzirira bvunzo 1 Shandisa test chromatogram kuona chromatographic kuchena uye tsvina.
Nguva dzekuchengeta:
L-4-Nitrophenylalanine Methyl Ester HCl 1.0 (kuchengeta nguva inenge maminitsi 11.4)
4-Nitro-L-Phenylalanine Panenge 0.4
Toluene Inenge 2.3
Masvomhu
Mune chromatogram yakawanikwa kubva pakugadzirira bvunzo, mushure mekugadziriswa kusina chinhu, regeredza iyo yepamusoro nekuda kwetoluene.Taura iyo chromatographic kuchena, 4-Nitro-L-Phenylalanine zvemukati uye yakazara kusvibiswa mumuenzaniso nenzira yenzvimbo yekumisikidza.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
L-4-Nitrophenylalanine Methyl Ester HCl (H-Phe(4-NO2)-OMe·HCl) (CAS: 17193-40-7) iri pakati pekubatanidzwa kwemishonga yakasiyana-siyana yemishonga.L-4-Nitrophenylalanine Methyl Ester HCl inogona kushandiswa kugadzira Matijing-Su kubva kune mamwe maanti-HBV akasimba.L-4-Nitrophenylalanine Methyl Ester HCl inogona kushandiswa semishonga yepakati yeZolmitriptan (CAS: 139264-17-8).Zolmitriptan inosarudza serotonin receptor agonist ye1B uye 1D subtypes.Inonyanya kushandiswa mukurapa kwakanyanya kwekurwiswa kwemigraine kana isina aura uye misoro yesumbu.Zolmitriptan inotora simba kuburikidza nekusunga kune vanhu 5-HT1Band 5-HT1Dreceptors, zvichiita kuti cranial blood vessel constriction uye kusunungurwa kwemasensory neuropeptides kuburikidza nemagumo etsinga mu trigeminal system.
