Levodopa (L-DOPA) CAS 59-92-7 99.0 ~ 100.5% USP BP EP Standard Anti-Parkinson's Disease High Purity
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri uye mutengesi weLevodopa (L-DOPA) (CAS: 59-92-7) ine mhando yepamusoro, Anti-Parkinson's Disease.Semumwe wevatengesi vakuru veLevodopa muChina, Ruifu Chemical inopa inokwanisa Levodopa kusvika kune dzimwe nyika zviyero, seAJI, USP, EP, BP uye IP standard.Kukwanisa kugadzira matani 300 pagore.Isu tinogona kupa COA, kuendesa pasi rese, zvidiki uye huwandu hwakawanda huripo.Kana iwe uchida Levodopa,Please contact: alvin@ruifuchem.com
Chemical Name | Levodopa |
Mashoko anoreva zvakafanana | L-DOPA;3-(3,4-Dihydroxyphenyl)-L-Alanine;L-3-(3,4-Dihydroxyphenyl)alanine;3,4-L-Dihydroxyphenylalanine;3-Hydroxy-L-Tyrosine;L-3-Hydroxytyrosine;H-Tyr(3-OH)-OH |
Nhamba yeCAS | 59-92-7 |
Nhamba yeCAT | RF-API55 |
Stock Status | MuStock, Kukwanisa Kugadzira 300 Matani pagore |
Molecular Formula | C9H11NO4 |
Molecular Weight | 197.19 |
Melting Point | 276.0~278.0℃(lit.) |
Sensitive | Chiedza Sensitive, Mhepo Inonzwa |
Solubility mumvura | Zvishoma Soluble mumvura |
Solubility | Insoluble muChloroform, Ethanol, Benzene, Ether. |
Solubility mu1mol/L HCl | Inonyungudika muDilute Hydrochloric Acid.Kuda Kujeka |
Kugadzikana | Yakagadzikana.Haienderane ne yakasimba Oxidizing Agents.Chiedza uye Mhepo Inonzwa |
Brand | Ruifu Chemical |
Item | Zvinotsanangurwa |
Chitarisiko | Muchena kana Mukaka White Crystalline Powder |
Identification | Infrared Absorption Spectrum |
Kutenderera kweOptical [α]20/D | -1.27° kusvika -1.34° |
Kuonekwa kweSolution | Passes Test |
Particle Size | 100% Pfuura ne80 |
Related Substances | |
L-Tyrosina | ≤0.10% |
Levodopareted Compound | ≤0.10% |
3-Methoxytyrosine | ≤0.50% |
Zvose Zvisina Kuchena | ≤1.00% |
Kusachena Kusingazivi | ≤0.10% |
UV Spectrum MaxE1% 1cm | 137~147 (280nm) |
Heavy Metals (as Pb) | ≤10ppm |
Kurasika paKuomesa | ≤1.00% (pa105 ℃ ye4 Maawa) |
Residue paIgnition (Sulfated) | ≤0.10% |
Assay | 99.0%~100.5% |
PH | 4.5~7.0 (0.10g mu10ml yeH2O Kuzunguza kwemaMiniti gumi nemashanu) |
Test Standard | AJI/USP/BP/EP/IP/JP Standard |
Usage | Active Pharmaceutical Ingredient (API);Chirwere cheAnti-Parkinson |
Kutenderera kweOptical [EP]
Dissolve huwandu hwakaenzana ne0.200g yedreied substance uye 5g yehexamethylenetetramine R mu 10ml ye 1mol/L hydrochloric acid uye dilute kusvika 25.oml neasidhi yakafanana.Bvumira mhinduro kumira yakadzivirirwa kubva kuchiedza kwe3h.Iko kona ye optical rotation ndeye -1.27 ° kusvika -1.34 °
Kuonekwa kweSolution
Disslove 1.0g mu1mol/L hydrochloric acid uye diluve kusvika 25ml neiyo solvnet yakafanana.Mhinduro haina kunyanya kupenya kupfuura referensi mhinduro BY6.
Zvinhu zvinoenderana [EP]
Ongorora neyakaonda-layer chromatography, uchishandisa cellulose yechromatography R sechinhu chekuputira.
Test solution-Dissolve 0.1g yechinhu chinofanirwa kuongororwa mu5ml yeanhydrous formic acid R uye diluted kusvika 10ml nemethanol R. Gadzirira pakarepo usati washandisa.
Reference solution (a)-Dilute 0.5ml yebvunzo mhinduro ku100ml ine methanol R.
Reference solution (b) -Dissolve 30mg ye tyrosine R mu 1ml ye anhydrous formic acid R uye shandura kusvika 100ml ne methanol R. Sanganisa 1ml yeiyi mhinduro ne 1ml yemhinduro yekuedza.
Isa zvakaparadzana mundiro semabhandi 20mm kureba, 1oμl yemubvunzo mhinduro, 10μl yereferensi mhinduro (a) uye 20μl yereferenzi mhinduro (b).Dry mumhepo inoyerera.Gadzira pamusoro penzira od 15cm uchishandisa musanganiswa we50 mavhoriyamu ebutanol R, 25 mavhoriyamu eglacial acetic acid R uye makumi maviri nemashanu emvura.Pukuta ndiro mumhepo inodziya uye pfapfaidza nemusanganiswa uchangogadzirwa wakaenzana nehuwandu hwe10 muzana m/v mhinduro yeferric chloride R uye 5 muzana m/v mhinduro ye postassium ferricyanide R. Ongorora ma chromatoframs nekukasika.Chero nzvimbo muchromatogram yakawanikwa nemhinduro yebvunzo, kunze kwenzvimbo huru, haina kusimba kupfuura nzvimbo iri muchromatogram inobatwa nereferensi mhinduro (a) inoratidza.Muedzo haushande kunze kwekunge chromatogram yawanwa nereferensi mhinduro (b) inoratidza, pamusoro penzvimbo huru, nzvimbo yakasarudzika yakanyanyisa kupfuura nzvimbo iri muchromatogram yakawanikwa nereferensi mhinduro (a).
UV Spectrum [EP]
Disslove 30.0mg mu 0.1mol/L hydrochloric acid uye dilute kusvika 100.oml neasidhi yakafanana.Dilute 10.0ml yemushonga uyu kusvika pa100.0ml ne0.1mol/L hydrochloric acid.Yakaongororwa pakati pe230nm uye 350nm, mhinduro inoratidza kumwe kunyura kwakanyanya pa280nm.Iyo chaiyo yekunyura pane iyi yakakura ndeye 137 kusvika 147, yakaverengerwa inoenderana neyakaomeswa chinhu.
Kurasika paKuomesa
Tora chigadzirwa ichi, chakaoma kuti chirambe chichirema pa 105 ° C, kurasikirwa kwehuremu hakufaniri kudarika 1.0% (General rule 0831).
Residue paIgnition (Sulfated)
Tora l.0g yeLevodopa uye utarise maererano nemutemo (General mutemo 0841).Zvakasara zvakasara hazvifaniri kudarika 0.1%.
Heavy Metals
Zvakasara zvakasara pasi pechinhu chekutora zvakasara zvemoto hazvifaniri kuva nezvikamu zvinopfuura gumi pamamiriyoni eheavy metal kana zvichiongororwa nemutemo (General Principles 0821, Law II).
pH Test
0.10g mu10ml yeH2O ichizunza kwemaminetsi gumi nemashanu.
Kutsunga kwemukati
Tora chigadzirwa ichi nezve 0.lg, kunyatsoyera kuyera, kuwedzera anhydrous formic acid 2ml kuti iparadze, wedzera glacial acetic acid 20ml, zunza, wedzera crystal violet chiratidzo 2 madonhwe, ane perchloric acid titration solution (0.1 mol / L) titration kune mhinduro iri girini, uye mhedzisiro yetitration inogadziriswa nebvunzo isina chinhu.Imwe neimwe 1 ml ye perchloric acid titration solution (0.1 mol/L) inoenderana ne19.72mg yeC9H11N04.
JP17 Test Method
Levodopa, kana yakaomeswa, ine kwete pasi pe98.5% yeLevodopa (C9H11NO4).
Tsanangudzo Levodopa inoitika sechena kana zvishoma greyi chena, makristasi kana crystalline poda.Hainhuhwi.Iyo inonyungudika zvakasununguka muformic acid, inonyungudika zvishoma mumvura, uye isingagoneke mu ethanol (95).Inonyungudika mu dilute hydrochloric acid.Iyo pH yesaturated solution yeLevodopa iri pakati pe5.0 ne6.5.Nzvimbo yakanyungudika: inenge 275 ℃ (ine kuora).
Identification
(1) Ku5 mL yemushonga weLevodopa (1 mu1000) wedzera 1mL yeninhydrin TS, uye kupisa kwemaminetsi matatu mukugeza nemvura: ruvara rwepepuru runokura.
(2) Ku 2 mL yemushonga weLevodopa (1 mu5000) wedzera 10 mL ye4-aminoantipyrine TS, uye zunza: ruvara rutsvuku runokura.
(3) Dissolve 3 mg yeLevodopa mu 0.001 mol / L hydrochloric acid TS kuita 100 mL.Sarudza iyo absorption spectrum yemhinduro sekurairwa pasi peUltravioletvisible Spectrophotometry <2.24>, uye enzanisa iyo spectrum neReference Spectrum: ese ari maviri anoratidza kusimba kwakafanana kwekunyura paawavelengths akafanana.
Absorbance <2.24> E 1% 1cm (280 nm): 136-146 (mushure mekuoma, 30 mg, 0.001 mol/L hydrochloric acid TS, 1000 mL).
Optical Rotation <2.49> [a]20D:-11.5° ~-13.0°(mushure mekuoma, 2.5 g, 1 mol/L hydrochloric acid TS, 50 mL, 100 mm).
Kuchena
(1) Kujeka uye ruvara rwekugadzirisa-Dissolve 1.0 g yeLevodopa mu 20 mL ye 1 mol / L hydrochloric acid TS: mhinduro yakajeka uye isina ruvara.
(2) Chloride <1.03>-Dissolve 0.5 g yeLevodopa mu6 mLof dilute nitric acid, woisa mvura kuita 50 mL.Ita bvunzo uchishandisa iyi mhinduro seyeyedzo mhinduro.Gadzirira mhinduro yekudzora ne 0.30 mL ye0.01 mol/L hydrochloricacid VS (kwete kupfuura 0.021%).
(3) Sulfate <1.14>-Dissolve 0.40 g yeLevodopa mu1 mL ye dilute hydrochloric acid uye 30 mL yemvura, woisa mvura kuita 50 mL.Ita bvunzo uchishandisa iyi mhinduro seyeyedzo mhinduro.Gadzirira mhinduro yekudzora ne 0.25 mL ye0.005 mol/L sulfuric acid VS (kwete kupfuura 0.030%).
(4) Heavy Metals <1.07>-Rambai ne 1.0 g yeLevodopa maererano neMethod 2, uye ita muedzo.Gadzirira mhinduro yekudzora ne 2.0 mL yeStandard Lead Solution (kwete kupfuura 20 ppm).
(5) Arsenic <1.11> -Dissolve 1.0 g yeLevodopa mu 5 mLof dilute hydrochloric acid, uye ita muedzo nemhinduro iyi semhinduro yekuedza (kwete kupfuura 2 ppm).
(6) Zvinhu zvinoenderana-Dissolve 0.10 g yeLevodopa mu10 mL ye sodium disulfite TS, uye shandisa mhinduro iyi semuenzaniso wemhinduro.Pipet 1 mL yemhinduro yemuenzaniso, wedzera sodium disulfite TS kuti iite 25 mL chaiyo.Pipeti 1 mL yemhinduro iyi, wedzera sodium disulfite TS kugadzira chaizvo 20 mL, uye shandisa iyi mhinduro seyakajairwa mhinduro.Ita bvunzo nemhinduro idzi sekurairwa pasi peThin-layer Chro-matography <2.03>.Spot 5mL imwe neimwe yemuenzaniso mhinduro uye yakajairwa mhinduro pandiro ye cellulose kune yakaonda-layerchromatography.Gadzira ndiro nemusanganiswa we1-butanol, mvura, acetic acid (100) uye methanol (10:5:5:1) kureba ingangoita masendimita gumi, uye woomesa ndiro.Sprayevenly mhinduro yeninhydrin muacetone (1 mu50) mundiro uye kupisa pa90 ℃ kwemaminetsi gumi: makwapa kunze kwenzvimbo huru kubva kumuenzaniso mhinduro haana kusimba kupfuura nzvimbo kubva kune yakajairwa mhinduro.
Kurasikirwa paKuomesa <2.41> Kwete kupfuura 0.30% (1 g, 105℃,3 maawa).
Residue paIgnition <2.44> Kwete kupfuura 0.1% (1 g).
Assay Wema nemazvo nezve 0.3 g yeLevodopa, yakamboomeswa, nyungudika mu3 mL yeformic acid, wedzera 80 mL yeacetic acid (100), uye titrate <2.50> ne0.1 mol/L perchloric acid VS kusvika ruvara rwemushonga rwachinja. kubva kupepuru kuburikidza nebhuruu-girinhi kusvika kugirinhi (chiratidzo: 3 madonhwe ecrystalviolet TS).Ita chisungo chisina chinhu, uye ita chero gadziriso inodiwa.
Imwe mL ye0.1 mol/L perchloric acid VS=19.72 mg yeC9H11NO4
Midziyo uye kuchengetedza Containers-Tight midziyo.
Kuchengetedza-Chiedza-chinodzivirira.
Hazard Codes | Xn | RTECS | AY5600000 |
Risk Statements | 22-36/37/38-20/21/22 | F | 10-23 |
Safety Statements | 26-36-24/25 | TSCA | Ehe |
WGK Germany | 3 | HS Code | 2922509099 |
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chiedza nemhepo zvinonzwa. Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera, yakaoma uye inofefetera kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza, mweya uye mwando.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
![](https://www.ruifuchemical.com/uploads/23.jpg)
Levodopa (L-DOPA) (CAS 59-92-7) inoshandiswa mukurapa kweParkinson's Disease.Levodopa (L-DOPA), mushonga wakavimbika uye unoshanda unoshandiswa mukurapa parkinsonism, unogona kutorwa senzira yekutsiva kurapwa.Levodopa inoshandiswa zvakanyanya kurapa marudzi ese e parkinsonism kunze kweaya akabatana neantipsychotic drug therapy.Levodopa ndiyo biochemical precursor ye dopamine.Inoshandiswa kusimudza dopamine mazinga mu neostriatum yevarwere veparkinsonian.Dopamine pachayo haiyambuki ropa-brain barriers uye saka haina CNS mhedzisiro.Nekudaro, Levodopa, seamino acid, inotakurwa muuropi nemaamino acid ekufambisa masisitimu, uko inoshandurwa kuita dopamine neiyo enzyme L-aromatic amino acid decarboxylase.Kana Levodopa ichishandiswa yoga, inonyanya kushandiswa neL-aromatic amino acid decarboxylase muchiropa, itsvo, uye gastrointestinal turakiti.Kudzivirira iyi peripheral metabolism, Levodopa inotungamirirwa pamwe chete neCarbidopa (Sinemet), peripheral decarboxylase inhibitor.Iko kusanganiswa kweLevodopa neCarbidopa kunoderedza dhigirii inodiwa yeLevodopa uye inoderedza mhedzisiro ine chekuita nekutonga kwayo.Levodopa inoshandiswa zvakanyanya kurapa marudzi ese e parkinsonism kunze kweaya akabatana neantipsychotic drug therapy.Zvisinei, sezvo parkinsonism inofambira mberi, nguva yekubatsira kubva kune imwe neimwe dose yeLevodopa inogona kupfupisa (kupfeka-kubvisa maitiro).Varwere vanogonawo kukura kamwe kamwe, kusingatarisirwi kuchinja pakati pekufamba uye kusafamba (pa-off effect).Mukati memaminitsi mashoma, murwere ari kunakidzwa nekufamba kwakajairika kana kunenge kwakajairika angaerekana atanga mwero wakakomba weparkinsonism.Zviratidzo izvi zvinogona kunge zvichikonzerwa nekufambira mberi kwechirwere uye kurasikirwa kwestriatal dopamine nerve terminals.
-
Levodopa (L-DOPA) CAS 59-92-7 99.0~100.5% USP B...
-
Cefotiam Hydrochloride CAS 66309-69-1 Purogiramu USP S...
-
Doxorubicin Hydrochloride CAS 25316-40-9 API US...
-
Enalapril Maleate CAS 76095-16-4 Assay 98.0~102...
-
Guanfacine Hydrochloride Guanfacine HCl CAS 291...
-
Naltrexone Hydrochloride CAS 16676-29-2 API USP...
-
Levetiracetam LEV CAS 102767-28-2 API Factory U...
-
Palonosetron Hydrochloride CAS 135729-62-3 Puri...
-
Noscapine Hydrochloride Hydrate CAS 912-60-7 AP...
-
Irinotecan Hydrochloride CAS 100286-90-6 Kuchena...
-
Ropivacaine Hydrochloride Monohydrate CAS 13211...
-
Tetracaine Hydrochloride CAS 136-47-0 API USP S...
-
Sorafenib Tosylate CAS 475207-59-1 Kuchena ≥99.0...
-
Purogiramu inonzi CAS 274901-16-5 Purity ≥99.0% (HPLC)
-
Bortezomib CAS 179324-69-7 Kuchena ≥99.0% (HPLC)...
-
Esmolol Hydrochloride CAS 81161-17-3 Kuchena ≥99...