LCZ696 Yepakati CAS 1426129-50-1 Kuchena ≥98.0% (HPLC) ee ≥99.0% Factory High Purity
Commercial Supply LCZ696 (CAS: 936623-90-4) Vanopindirana Vanoenderana:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium munyu) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Sacubitril musanganiswa neValsartan CAS: 936623-90-4
| Chemical Name | (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate |
| Mashoko anoreva zvakafanana | LCZ696 yepakati |
| Nhamba yeCAS | 1426129-50-1 |
| Nhamba yeCAT | RF-PI169 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram |
| Molecular Formula | C20H25NO3 |
| Molecular Weight | 327.42 |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Ichena kusvika kuOff-White Powder |
| Kuchena / Analysis Method | ≥98.0% (HPLC) |
| Enantiomeric Kuwedzera | iye: ≥99.0% |
| Kunyorova (KF) | ≤1.0% |
| Zvinhu zvinoenderana A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Zvinhu zvinoenderana B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oxide |
| Zvimwe Zvinhu | ≤1.0% |
| Zvose Zvisina Kuchena | ≤2.0% |
| Test Standard | Enterprise Standard |
| Usage | Pakati peLCZ696 (CAS: 936623-90-4) mukurapa kweHFrEF |
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
Mugadziri ane Kuchena Kwepamusoro uye Hwakagadzikana Hunhu
Commercial Supply LCZ696 (CAS: 936623-90-4) Vanopindirana Vanoenderana:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium munyu) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Sacubitril musanganiswa neValsartan CAS: 936623-90-4
LCZ696 mushonga wekuedza wakagadzirwa neNovartis Pharmaceutical wekuUnited States kuitira kurapwa kwevarwere vane Heart Failure neyakaderedzwa Ejection Fraction (HFrEF).Kukundikana kwemoyo chirwere chinotyisa.Mwoyo wemurwere haugone kupomba ropa rakakwana kuti ripe muviri, uye kuoneka zviratidzo zve dyspnea, kuneta uye kuchengetwa kwemvura zvishoma nezvishoma, ndokuzowedzera zvishoma nezvishoma, zvakanyanya kukanganisa hupenyu hwehupenyu.LCZ696 inogona kukwidziridza kuchengetedzwa kwemuviri kunopesana nekutadza kwemoyo, pamwe nekuwedzera mwero we natriuretic peptides uye mamwe endogenous vasoactive peptides, uye inhibit iyo renin-angiotensin-aldosterone system (RAAS).LCZ696 yakasanganiswa neNovartis's Hypertension Medication (Diovan, zita rezita: valsartan) uye mushonga wekuedza AHU-377.AHU377 inovhara maitiro emapeptides maviri ane chekuita nekudzikisa BP.Diovan inovandudza vasodilatation uye inomutsa muviri kuti ubvise sodium nemvura.
