Lesinurad (RDEA 594) CAS 878672-00-5 Kuchena > 99.5% (HPLC) Assay 98.0~102.0%

Tsanangudzo Pfupi

Zita reKemikari: Lesinurad

Anoreva zvakafanana: RDEA 594;Zurampic

CAS: 878672-00-5

Kuchena:> 99.5% (HPLC)

Chiyero: 98.0 ~ 102.0%

Chitarisiko: Muchena kusvika Kuchena-Upfu

Bata: Dr. Alvin Huang

Nharembozha/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Tsanangudzo:

Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira inogadzira Lesinurad (RDEA 594) (CAS: 878672-00-5) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Lesinurad uye Intermediates,Please contact: alvin@ruifuchem.com

Lesinurad Intermediates:

Chemical Properties:

Chemical Name Lesinurad
Mashoko anoreva zvakafanana 2-[[5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio]acetic Acid;2-[[5-Bromo-4-(4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl]thio]-Acetic Acid;RDEA 594;RDEA-594;RDEA594;Zurampic
Stock Status MuStock, Commercial Production
Nhamba yeCAS 878672-00-5
Molecular Formula C17H14BrN3O2S
Molecular Weight 404.28 g/mol
Melting Point >171℃(Zvita.)
Density 1.72±0.10 g/cm3
COA & MSDS Available
Origin Shanghai, China
Brand Ruifu Chemical

Zvinotsanangurwa:

Items Kuongorora Maitiro Results
Chitarisiko Ichena kusvika kuOff-White Powder Off-White Powder
Identification Nguva yekuchengetedza yepamusoro pepamusoro yemuenzaniso mhinduro inoenderana nereferensi chiyero Zvinoenderana
Mvura naKarl Fischer <0.50% 0.14%
Residue paIgnition <0.10% 0.03%
Masimbi anorema (Pb) ≤10ppm <10ppm
Zvinhu zvinoenderana (HPLC)    
The Largest Single tsvina <0.20% 0.07%
Zvose Zvisina Kuchena <1.00% 0.24%
Kuchena / Analysis Method >99.5% (HPLC Area) 99.76%
Assay 98.0~102.0% 99.6%
Infrared Spectrum Inopindirana neChimiro Zvinoenderana
NMR Spectrum Inopindirana neChimiro Zvinoenderana
Mhedziso Chigadzirwa chakaedzwa uye chinoenderana nezvakapihwa

Pakeji/Kuchengeta/Shipping:

Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.

Zvakanakira:

Yakakwana Capacity: Inokwana zvivakwa uye matekiniki

Professional Service: Imwe inomira kutenga sevhisi

OEM Package: Tsika pasuru uye label iripo

Fast Delivery: Kana iri mukati me stock, mazuva matatu ekutumira anovimbiswa

Yakagadzika Supply: Chengetedza zvine musoro stock

Tsigiro yehunyanzvi: Tekinoroji mhinduro iripo

Tsika Synthesis Service: Kubva pamagiramu kusvika makirogiramu

Hunhu Hwepamusoro: Yakagadzira yakakwana yemhando yekusimbisa system

FAQ:

Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.

Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.

Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.

HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.

Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.

Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.

MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.

Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.

Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.

Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.

Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.

Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.

878672-00-5 - Nhanganyaya:

Lesinurad (RDEA 594) (CAS: 878672-00-5) yakatenderwa neUS Food and Drug Administration (FDA) musi wa22 Zvita 2015, ndokuzotenderwa neEuropean Medicines Agency (EMA) muna Kukadzi 18, 2016. The komboni yakambogadzirwa neArdea.AstraZeneca yakawana kambani iyi muna 2012, iyo yakabva yawana chigadzirwa.Mushonga uyu unonzi Zurampic® muUnited States neEuropean Union.Lesinurad ndiyo yekutanga kubvumidzwa pasirese urate reuptake transporter (URAT1) inhibitor, yakasanganiswa ne xanthine oxidase inhibitors kurapa gout ine hyperuricemia.

878672-00-5 - Nzira Yekuita:

Lesinurad, zita rekutengesa Zurampic.Lesinurad pamwe chete ne xanthine oxidase inhibitor (XOI) ye hyperuricemic gout syndrome.Maitiro ayo ekuita ndeyekubatsira itsvo kubudisa uric acid, uye inoshanda nekudzivisa basa revatakuri vanobatanidzwa muuric acid reabsorption muitsvo.

878672-00-5 - In Vitro Zvidzidzo:

Lesinurad inhibits iyo uric acid yekufambisa basa (IC50 = 3.36 μM) yehURAT1 (munhu URAT1), iyo inopfuura 20 nguva inhibitory effect pa rURAT1 (rat URAT1) (IC50 = 74.84 μM).Lesinurad inhibit hURAT1 kuburikidza nekubatana kwekiyi amino acid yakasara Phe365.

Nyora meseji yako pano uye titumire kwatiri