Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 High Purity

Tsanangudzo Pfupi

Zita reKemikari: Lopinavir

CAS: 192725-17-0

Chitarisiko: Chichena kusvika Kuvhara Hupfu Huchena

Assay (HPLC): 98.0% ~ 102.0%

Sarudza Peptidomimetic HIV-1 Protease Inhibitor

API High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com

Tumira email kwatiri

Product Detail

Product Tags

Tsanangudzo:

Mugadziri Wekutengesa ane Kuchena Kwepamusoro uye Hunhu Hwakagadzikana
Zita reKemikari: Lopinavir
CAS: 192725-17-0
Yakanyanya Kusimba, Inosarudza Peptidomimetic HIV-1 Protease Inhibitor
COVID-19 Related Research Chigadzirwa
API High Quality, Commercial Production

Chemical Properties:

Chemical Name	Lopinavir
Mashoko anoreva zvakafanana	LPV;ABT-378;Kaletra
Nhamba yeCAS	192725-17-0
Nhamba yeCAT	RF-API73
Stock Status	MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram
Molecular Formula	C37H48N4O5
Molecular Weight	628.81
Kuchengetedza Kwenguva Yakareba	Chengetedza Nguva refu pa2-8 ℃
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	Ichena kusvika kuOff-White Powder
Solubility	Yemahara Soluble muMethanol uye muEthanol, Soluble mu2-Propanol
Kuzivikanwa IR	Iyo infrared absorption spectrum yemuyedzo sampuli inopindirana neiyo spectrum yereferensi chiyero.
Kuzivikanwa HPLC	Nguva yekuchengeta yemuenzaniso webvunzo inoenderana neiyo yereferensi mwero
Mvura Yemukati (neKF)	≤4.0%
Specific Optical Rotation	-22.0° kusvika -26.0°
Residue paIgnition	≤0.20%
Heavy Metals	≤20ppm
Melting Point	124.0 kusvika 127.0 ℃
Sulfated Ash	≤0.20%
Residual Solvent (Ethanol)	≤0.50%
Related Substances	(HPLC, Nzvimbo%)
Kusachena 1
Kusachena B (RRT=0.07)	≤0.20%
Kusachena I (RRT=1.10)	≤0.20%
Chero Kumwe Kusachena	≤0.10%
Kusachena 2	Chero Kumwe Kusachena Kwemunhu ≤0.10%
Yese Kusachena kubva muKutaridza 1 uye 2	≤0.70%
Zvose Zvisina Kuchena	≤1.0%
Assay (neHPLC)	98.0%~102.0%
Test Standard	Enterprise Standard
Usage	Sarudza Peptidomimetic HIV-1 Protease Inhibitor, COVID-19 Inoenderana Netsvagiridzo Chigadzirwa

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.

Zvakanakira:

FAQ:

Application:

Lopinavir (ABT-378) ine simba zvakanyanya, inosarudza peptidomimetic inhibitor yeHIV-1 protease, ine Kis ye1.3 kusvika 3.6 pM yemhando yemusango uye mutant HIV protease.Lopinavir inoita nekusunga kukura kweHIV-1 nekudaro ichivharira kusatapukira kwayo.Lopinavir zvakare iri SARS-CoV 3CLpro inhibitor ine IC50 ye14.2 μM.Lopinavir iantiretroviral yekirasi yeprotease inhibitor.Kuvharirwa kweHIV-1 protease kunodzivirira kutsemuka kwehutachiwana hwepolyprotein precursor uye kunoguma nekuburitswa kwemavirioni asina kusimba, asina kutapuriranwa.Chikamu chemusanganiswa kurapa kurapa HIV/AIDS.Lopinavir, yechitanhatu HIV protease inhibitor mukirasi ye “navir”, yakatangwa mukubatana ne ritonavir, imwe HIV protease inhibitor yatotengeswa (Abbott, 1996);kuumbwa kwepakutanga uku kwakaunzwa seKaletra kuti ishandiswe pamwe chete nenucleoside kana kuti non-nucleoside reverse transcriptase inhibitors yekurapa AIDS muvakuru nevana.Lopinavir mukomboni wepeptidomimetic une musimboti wakafanana nereritonavir, apo mapoka ekupedzisira, kunyanya yakagadziridzwa valine, akaunzwa nepeptide coupling maitiro.Lopinavir inhibitor ine simba inokwikwidza yeHIV-I protease inoratidza kugona kwakanyanya kupesana ne ritonavir-resistant mutations.Mumarudzi akati wandei emhuka, zvidzidzo zvepharmacokinetic pamwe nesangano relopinavirlritonavir zvakaratidza kuti zvimiro zvine mwero zvelopinavir zvakavandudzwa zvakanyanya pamberi pe ritonavir, maererano neCmax uye nguva yekuita.