Losartan Potassium CAS 124750-99-8 API Factory Antihypertensive High Purity
Ipa Losartan Potassium uye Inoenderana Nepakati neYakakwira Hunhu
Losartan Potassium CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Chemical Name | Losartan Potassium |
| Mashoko anoreva zvakafanana | DUP 753;Cozaar;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Munyu |
| Nhamba yeCAS | 124750-99-8 |
| Nhamba yeCAT | RF-API98 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C22H22ClKN6O |
| Molecular Weight | 461.01 |
| Melting Point | 263.0~265.0℃ |
| Solubility | Yakasununguka Soluble muMvura uye muMethanol, Zvishoma Soluble muAcetonitrile. |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Ichena kana Inenge Yakachena Crystalline Powder |
| Identification A | Infrared Absorption: Inofanirwa Kufanana neReference Standard |
| Kuzivikanwa B | Ultraviolet absorption: Inofanirwa Kufanana neReference Standard |
| Kuedza kwePotassium | Inofanira kuva Positive |
| Zvemumvura (KF) | ≤0.50% |
| Heavy Metals | ≤10ppm |
| Zvinhu zvinoenderana (HPLC) | |
| Chero Kusachena Kwemunhu | ≤0.20% |
| Zvose Zvisina Kuchena | ≤0.50% |
| Residual Solvents (GC) | |
| Cyclohexane | ≤0.10% |
| Isopropyl Doro | ≤0.20% |
| Assay/Analysis Method | 98.5 ~ 101.0% (HPLC, yakaverengerwa pane anhydrous, solvent-isina hwaro) |
| N-Nitrosodiethylamine | ≤0.177ppm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Particle Size | 90% Isingasviki 38 Microns |
| Sherufu Hupenyu | 24 Mwedzi |
| Test Standard | Enterprise Standard |
| Usage | API, Angiotensin II Receptor Antagonist Antihypertensive |
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
Losartan Potassium ndiye wekutanga ane simba uye anosarudza asiri-peptide angiotensin II receptor mhando 1 (AT1) antagonist akaunzwa kumusika seanoro-zuva nezuva remuromo antihypertensive.Iko kusungirirwa kunodzivisa 50% yekusungwa kweangiotensin II (IC50) ndeye 20 nM.Losartan (40 μM) inokanganisa ISC asi inodzivirira mhedzisiro yeANGII paISC.Losartan inoderedza zvakanyanya Ang II-mediated cell kuwanda mumasero egomarara re endometrial.Iko kusanganiswa kwe losartan uye anti-miR-155 kune yakakura zvakanyanya antiproliferative effect kana ichienzaniswa nemushonga wega wega.Inogadziriswa kugadzira iyo 5-carboxylic acid metabolite (EXP3174) uye inonzi inoderedza BP.Parizvino iri kutsvagirwa senge ingangoita kurapa kweCCIDID-19 kuitira kugona kwayo kudzikisira kana kudzikamisa zviratidzo zveCOVID-19.
1. Kurapa kwehutano hwakakosha, inogona kushandiswa yoga kana kusanganiswa nemamwe madhiragi antihypertensive (akadai se diuretics).2. Kurapa kwekushaya simba kwemoyo, inogona kushandiswa yoga kana kusanganiswa ne cardiotonic kana diuretic Chemicalbook zvinodhaka.3. Kudzivirira sitiroko kune varwere vane hypertension uye left ventricular hypertrophy.4. Inoshandiswa kuderedza kufambira mberi kwenephropathy kune varwere vane chirwere cheshuga chechipiri chinosanganiswa nenephropathy uye hypertension.
