Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8 Kuchena > 98.0% (GC) Lenvatinib Mesylate Intermediate Factory

Tsanangudzo Pfupi:

Kemikari Zita: Methyl 4-Amino-2-Methoxybenzoate

CAS: 27492-84-8

Kuchena: > 98.0% (GC)

Chitarisiko: Ichena kusvika Kuchena-Ichena Powder kana Makristasi

Pakati peLenvatinib Mesylate CAS 857890-39-2

E-Mail: alvin@ruifuchem.com


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Tsanangudzo:

Chemical Properties:

Chemical Name Methyl 4-Amino-2-Methoxybenzoate
Mashoko anoreva zvakafanana 4-Amino-2-Methoxybenzoic Acid Methyl Ester;Methyl 4-Amino-o-Anisate;4-Amino-o-Anisic Acid Methyl Ester
Nhamba yeCAS 27492-84-8
Nhamba yeCAT RF-PI1974
Stock Status MuStock, Kugadzirwa Kunokwira Kusvika Matani
Molecular Formula C9H11NO3
Molecular Weight 181.19
Density 1.179±0.060 g/cm3
Brand Ruifu Chemical

Zvinotsanangurwa:

Item Zvinotsanangurwa
Chitarisiko Ichena kusvika kuOff-White Powder kana Makristasi
Kuchena / Analysis Method >98.0% (GC)
Kuchena / Analysis Method 97.5 ~ 102.5 (Nonaqueous Titration)
Melting Point 157.0~161.0℃
Kurasika paKuomesa <1.00%
Zvose Zvisina Kuchena <2.0%
Infrared Spectrum Inopindirana neChimiro
Proton NMR Spectrum Inopindirana neChimiro
Test Standard Enterprise Standard
Usage Pakati peLenvatinib Mesylate (CAS: 857890-39-2)

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro

Zvakanakira:

1

FAQ:

Application:

Methyl 4-Amino-2-Methoxybenzoate (CAS: 27492-84-8) inogona kushandiswa sepakati peLenvatinib Mesylate (CAS: 857890-39-2).Lenvatinib imishonga yekenza yekenza yakagadzirwa neEisai Corporation yeJapan (Code: E7080), iri ye inhibitor ye oral multi-receptor tyrosine kinase (RTK) uye inogona kudzivisa kinase chiitiko chevascular endothelial growth factor (VEGF) Receptors VEGFR1 ( FLT1), VEGFR2 (KDR), uye VEGFR3 (FLT4).Lenvatinib inogonawo kudzivisa kubatanidzwa kwemamwe maRTK mu pathological angiogenesis, tumor kukura, uye kukura kwekenza kunze kwemaitiro avo emagetsi emagetsi anosanganisira fibroblast growth factor (FGF) receptors FGFR1, 2, 3, uye 4;platelet-derived growth factor receptor (PDGFR [alpha]), KIT, uye RET.[Zviratidzo]: Lenvatinib inokodzera kurapwa kwevarwere vekenza yethyroid yemunharaunda kudzoka kana metastasis rudzi, progressivity rudzi uye radioactive iodine-refractory differentiated type.Musi waKukadzi 13, 2015, US FDA yakabvumidza mushonga weanticancer Lenvatinib kurapa cancer yegomarara.Lenvatinib inonzi multi-target enzyme inhibitor, inokwanisa kuvharidzira VEGFR2 uye VEGFR3 (vascular endothelial growth factor receptor).Zita rekutengesa reLenvatinib ndiLenvima.Musi waChivabvu 20, 2015, European Medicines Agency (EMA) yakabvumidza Lenvatinib kurapwa kweanoparadza, munharaunda yepamusoro kana metastatic kusiyaniswa (papillary, follicular, Hurthle type) thyroid cancer (DTC).Mukutongwa, nguva yepakati yekupona kwevarwere veradioactive iodine-refractory DTC vakarapwa neLenvatinib yaive mwedzi gumi nemisere nepo kukosha kwevarwere vanotora placebo kuri mwedzi mitatu chete.

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