N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Purity>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Tsanangudzo Pfupi:

Kemikari Zita: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1

Kuchena:> 99.0% (HPLC)

Chitarisiko: Yero Yero kusvika Yero Upfu

Pakati peAfatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Tumira email kwatiri

Product Detail

Product Tags

Tsanangudzo:

Ruifu Chemical Supply Intermediates yeAfatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imwe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Chemical Name	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Mashoko anoreva zvakafanana	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl)(7-Fluoro-6-Nitroquinazolin-4-yl)amine;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazoline;Afatinib Intermediate A
Nhamba yeCAS	162012-67-1
Nhamba yeCAT	RF-PI2026
Stock Status	MuStock, Kugadzirwa Kunokwira Kusvika Matani
Molecular Formula	C14H7ClF2N4O2
Molecular Weight	336.68
Sensitivity	Mhepo Inonzwa, Inonzwa Kupisa
Melting Point	242.0~244.0℃
Boiling Point	489℃
Density	1.616
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	Yero Yero kusvika Yero Hupfu
Kuchena / Analysis Method	>99.0% (HPLC)
Kurasika paKuomesa	<0.50%
Residue paIgnition	<0.20%
Related Substances
Kusachena Kwemunhu	<0.50%
Zvose Zvisina Kuchena	<1.00%
Heavy Metals	≤20ppm
Infrared Spectrum	Inopindirana neChimiro
Proton NMR Spectrum	Inopindirana neChimiro
Test Standard	Enterprise Standard
Usage	Pakati peAfatinib Dimaleate (CAS: 850140-73-7)

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro

Zvakanakira:

FAQ:

Application:

N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) iri pakati pekugadzirisa kweAfatinib Dimaleate (CAS: 850140-73-7) .Afatinib Dimaleate imhando yemunyu yeAfatinib.Afatinib chizvarwa chechipiri, chinoshandiswa nemuromo, chisingachinjiki inhibitor yeErbB mhuri ye tyrosine kinases.Mechanism of ActionAfatinib inoderedza zviratidzo zveErbB kuburikidza nekubatana zvakasimba kune kinase domains ye epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER) 2 uye HER4, zvichiita kuti inhibition isingagadziriswi ye tyrosine kinase autophosphorylation;iyo inodzivisawo transphosphorylation yeHER3.Afatinib inobvumirwa se monotherapy yekurapa kweEGFR tyrosine kinase inhibitor (TKI) -vasina ruzivo rwevanhu vakuru vane nzvimbo yepamusoro kana TsanangudzoChEBI: Munyu we maleate unowanikwa nekubatanidza afatinib nemhando mbiri dze molar dze maleic acid.Inoshandiswa pakurapa-mutsara wevarwere vane metastatic isiri-diki cell kenza yemapapu.