Pfizer iri kutsvaga mvumo yekushandiswa kwekukurumidzira kubva kuFDA yerinoveli Covid-19 antiviral piritsi Paxlovid.
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Pazvitsitsinho zveMerck antiviral molnupiravir's UK mvumo, Pfizer atanga kutora ega Covid-19 piritsi, Paxlovid, pamusika.Vhiki rino, mugadziri wezvinodhaka wekuUS akatsvaga mvumo yekushandiswa kwekukurumidzira kubva kuUS Food and Drug Administration (FDA) yeanovherwa antiviral mumiriri muvanhu vane hunyoro kusvika-pakati Covid-19, vari panjodzi huru yekuiswa muchipatara kana kufa. Pfizer ane zvakare vakatanga hurongwa hwekutsvagira mvumo yekutonga kune dzimwe nyika dzinosanganisira UK, Australia, New Zealand neSouth Korea, uye varonga kuisa mamwe maapplication.Paxlovid anoshanda sei?Paxlovid musanganiswa wePfizer's investigational antiviral PF-07321332 uye mwero wakaderera we ritonavir, mushonga weantiretroviral wagara uchishandiswa kurapa HIV.Kurapa uku kunokanganisa kudzokororwa kweSARS-CoV-2 mumuviri nekusunga kune 3CL-senge protease, enzyme yakakosha pakuita kwehutachiona uye kubereka.
Zvinoenderana neongororo yechinguvana, Paxlovid akadzikisa njodzi yeCovid-19-yakabatana muchipatara kana kufa ne89% mune avo vakagamuchira kurapwa mukati memazuva matatu ekutanga kwechiratidzo.Mushonga uyu wakawanikwa uchishanda zvakanyanya - 1% chete yevarwere vakagamuchira Paxlovid vakaiswa muchipatara mukati mezuva rechi28 zvichienzaniswa ne6.7% yevatori vechikamu ve placebo-kuti muyedzo wayo weChikamu II/III wakapera nekukurumidza uye kuendeswa kwemutemo kuFDA kwakamhan'arwa nekukurumidza kupfuura. zvinotarisirwa.Uyezve, nepo 10 kufa kwakataurwa paruoko rwe placebo, hapana yakaitika pakati pevatori vechikamu vakagamuchira Paxlovid.Kunge molnupiravir, Paxlovid inopihwa nemuromo, zvichireva kuti varwere veCovid-19 vanogona kutora mushonga uyu kumba mukutanga kwehutachiona.Tarisiro ndeyekuti mishonga mitsva inorwisa mavhairasi seaya anobva kuMerck nePfizer anotendera vanhu vane zvinyoro kana zvine mwero nyaya dzekoronavirus kuti varapwe nekukurumidza, kudzivirira kufambira mberi kwechirwere uye kubatsira kudzivirira zvipatara kuti zvisaremerwe.
Covid-19 makwikwi emishongaMerck's molnupiravir, piritsi rekutanga rakatenderwa Covid-19, rave richinzi rinogona kuchinja mutambo kubvira apo zvidzidzo zvakawana kuti yakaderedza kuchipatara uye njodzi yekufa nezvikamu makumi mashanu muzana.Asi hazvireve kuti Pfizer's antiviral inopa haizove nemupendero mumusika.Ongororo yechinguvana yekushanda kwe molnupiravir iri kuvimbisa, asi kudzikiswa kwakanyanya kwenjodzi kwakataurwa naPfizer kunoratidza kuti piritsi rayo rinogona kuratidzawo chombo chakakosha mudura rehurumende kurwisa denda iri. muvengi antiviral.Dzimwe nyanzvi dzakaratidza kushushikana kuti molnupiravir maitiro ekuita kurwisa Covid-19 - kutevedzera mamorekuru eRNA kukonzeresa shanduko yehutachiona - inogonawo kuunza shanduko dzinokuvadza mukati meDNA yevanhu.Paxlovid, imwe mhando yeantiviral inozivikanwa seprotease inhibitor, haina kuratidza zviratidzo zve "mutagenic DNA interactions", akadaro Pfizer.
Nguva yekutumira: Nov-19-2021