Octreotide Acetate CAS 83150-76-9 Peptide Purity (HPLC) ≥98.0% API High Quality

Octreotide Acetate (Sandostatin) is a synthetic peptide analogue yehomoni somatostatin, ndeyenguva yakareba inobata somatostatin analog inoratidzwa sechiratidzo chekudzora mune acromegaly uye gastroenteropancreatic tumors.Zvimwe zvinogona kushandiswa pasi pekuferefetwa zvinosanganisira chirwere cheshuga, psoriasis uye chirwere cheAlzheimer.Octreotide Acetate (Sandostatin) inogadzirwa peptide analogue yehomoni somatostatin.Zviito zvaro zvinosanganisira inhibition yepituitary secretion yekukura kwehomoni uye inhibition yepancreatic islet cell secretion ye insulin uye glucagon.Kusiyana ne somatostatin, iyo ine plasma hafu yeupenyu hwemaminetsi mashoma, Octreotide ine plasma yekubvisa hafu yehupenyu hwe1 kusvika maawa maviri.Kubuda kwemushonga kunonyanya kuve renal.Octreotide inoderedza gastrointestinal motility uye inhibits contraction of gall bladder.

Peptide zvinodhaka Novartis Sandostatin (Octreotide Acetate), inogadzirwa yakasikwa somatostatin octapeptide derivatives, inoramba iine pharmacological effect yakafanana neye somatostatin, uye mhedzisiro yacho inogara kwenguva refu.Zviratidzo zveOctreotide Acetate zvinosanganisira acromegaly;Kuderedzwa kwezviratidzo uye zviratidzo zvine chekuita nekushanda gastroenteropancreatic endocrine neoplasia;Uye kushanda muCarcinoid Tumors inounza necarcinoid syndrome, VIP tumors, uye glucagon tumors.Mukuwedzera, Octreotide Acetate ye gastrinomas/Zollinger-Ellison syndrome (kazhinji inosanganiswa neproton pump inhibitors kana H2 receptor blockers), Insulinomas (preoperative kudzivirira hypoglycemia nekuchengetedza shuga yeropa yakajairwa), chiyero chinoshanda chekukura kwehomoni inoburitsa chinhu bundu ndeye. anenge 50%.

Octreotide Acetate inshuwarisi yenyika yehutano Kirasi B mushonga, inova yakagadzirwa yakasikwa octapeptide inotorwa somatostatin, kana ichienzaniswa neyakasikwa somatostatin, iyo hafu yeupenyu ye somatostatin iri pachena yakarebesa uye ine yakafanana pharmacological mhedzisiro, kusanganisira inhibition yekukura kwehomoni basa, inhibition. yegastric acid, pancreatic enzyme, glucagon uye insulin secretion, uye kuderedzwa kwe visceral kubuda kweropa, kuderedza gastrointestinal motility.Kana ichienzaniswa neyakazvarwa somatostatin, octreotide ine hafu yehupenyu hurefu, inonyanya kusarudza kuvharidzira kukura kwehomoni secretion pane inhibition ye insulin secretion, uye haikonzeri rebound hypersecretion yehomoni.1, Kudzora kuvhiyiwa kana kurapa kwemwaranzi hakugone kudzora zvakakwana chirwere kune varwere vane acromegaly zviratidzo uye kuderedza murwere kukura kwehomoni (GH) insulin-yakafanana nekukura chinhu -1 (1GF-1) plasma mazinga.Sandostatin inogonawo kushandiswa kurapa varwere vane acromegaly vasingakwanisi kana vasingadi kuvhiyiwa, kana kurapa varwere vane acromegaly vasati vawana radiation therapy.2. Kuderedza zviratidzo zvine chokuita nekushanda kwegastroenteropancreatic (GEP) endocrine tumors dzakadai secarcinoid tumors ine carcinoid syndrome zviratidzo.Sandostatin haisi mushonga unorwisa cancer uye hairapi varwere ava.3, Kudzivirirwa kwematambudziko mushure mekuvhiyiwa kwepancreatic.4, Chiropa cirrhosis varwere vane gastric-esophageal variceal kubuda ropa kunokonzerwa nekukurumidzira kurapwa, hemostasis nekudzivirira kubudazve, Sandostatin inofanira kusanganiswa ne endoscopic sclerotherapy uye kumwe kurapa kwakakosha.