Olaparib AZD-2281 CAS 763113-22-0 Purity ≥99.0% API Factory
High Purity, Commercial Production
Olaparib uye Hukama hwepakati:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid CAS 763114-26-7
1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Chemical Name | Olaparib |
| Mashoko anoreva zvakafanana | AZD-2281;KU0059436;Lynparza;4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-imwe;1-(Cyclopropylcarbonyl) -4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]piperazin |
| Nhamba yeCAS | 763113-22-0 |
| Nhamba yeCAT | RF-API103 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram |
| Molecular Formula | C24H23FN4O3 |
| Molecular Weight | 434.46 |
| Solubility | Soluble muDMSO |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Ichena kusvika kuOff-White Powder |
| Kuzivikanwa ne1H NMR | Teerera nechimiro |
| LC-MS | Teerera nechimiro |
| Kuchena / Analysis Method | ≥99.0% (neLC-MS) |
| Kunyorova (KF) | ≤0.50% |
| Kusachena Kumwechete | ≤0.50% |
| Zvose Zvisina Kuchena | ≤1.0% |
| Heavy Metals (as Pb) | ≤20ppm |
| Test Standard | Enterprise Standard |
| Usage | API;PARP Inhibitor |
Package: Bhodhoro, Aluminium foil bag, Cardboard Drum, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro.
Olaparib (CAS: 763113-22-0), ine simba uye inosarudza PARP-inhibitor.Muna Zvita 19, 2014, iyo FDA yakabvumidza riini rinopesana negomarara mushonga Olaparib (Lynparza) we monotherapy kune varwere vekenza yepamusoro ye ovarian avo vakaita kanenge katatu kutenderera kwechemotherapy kana varwere vanofungidzirwa kuti BRCA shanduko.Panguva imwecheteyo, FDA yakabvumidza kuwanda uye kupatsanurwa kwemakiti ekuongorora kuti aonekwe shanduko muBRCA1 uye BRCA2, BRCAanalysis CDx.Olaparib ndiyo yekutanga PARP inhibitor mishonga yakatenderwa neFDA.Muna Kukadzi 2, 2015, European Union Food and Drug Administration (EMA) yakatenderawo Olaparib kuti ipinde mumusika munyika makumi maviri nesere dzeEuropean Union dzinosanganisira Iceland, Liechtenstein neNorway.Asi zviratidzo zveEMA neFDA zvakatenderwa zvakasiyana zvishoma;yekutanga ndeye BRCA gene mutation kesi, uye zvakare yekurapa kwekurapa kwevarwere vepamusoro epithelial ovarian cancer vakambogamuchira platinum-ine chemotherapy mishonga uye kuratidza mhinduro uye zvichienderana nekudzoka.
