Ondansetron Hydrochloride Dihydrate CAS 103639-04-9 Assay 98.0~102.0%

Tsanangudzo Pfupi

Kemikari Zita: Ondansetron Hydrochloride Dihydrate

CAS: 103639-04-9

Chiyero: 98.0 ~ 102.0% (Yakaverengerwa pane anhydrous hwaro)

Chitarisiko: Muchena kana Kunze-Ichena Crystalline Powder

A Specific Serotonin (5-HT3) Receptor Antagonist.Antiemetic

Bata: Dr. Alvin Huang

Nharembozha/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Tsanangudzo:

Shanghai Ruifu Chemical ndiyo inotungamira mugadziri weOndansetron Hydrochloride Dihydrate (CAS: 103639-04-9) ine mhando yepamusoro.Ruifu inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, diki uye yakawanda yakawanda iripo.Tenga Ondansetron Hydrochloride Dihydrate,Please contact: alvin@ruifuchem.com

Related Intermediates:

Chemical Properties:

Chemical Name Ondansetron Hydrochloride Dihydrate
Mashoko anoreva zvakafanana Ondansetron HCl Dihydrate;1,2,3,9-Tetrahydro-9-Methyl-3-[(2-Methyl-1H-imidazol-1-yl) methyl]-4H-Carbazol-4-one Hydrochloride Dihydrate;Emeset;GR 38032 Hydrochloride Dihydrate;SN 307 Hydrochloride Dihydrate;GR 3832 HCl 2H2O;SN-37 HCl 2H2O;NSC665799 HCl 2H2O
Stock Status MuStock, Commerce Scale
Nhamba yeCAS 103639-04-9 (Dihydrate)
Inoenderana CAS RN 99614-02-5 (Base) & 99614-01-4 (Anhydrous)
Molecular Formula C18H19N3O·HCl·2H2O
Molecular Weight 365.86 g/mol
Melting Point 176.0 kusvika 180.0 ℃
Sensitive Heat Sensitive
Mvura Solubility Soluble mumvura (> 5 mg/ml)
Storage Temp. Nzvimbo Inotonhorera & Yakaoma (2~8℃)
COA & MSDS Available
Brand Ruifu Chemical

Zvinotsanangurwa:

Items Kuongorora Maitiro Results
Chitarisiko Ichena kusvika kuOff-White Crystalline Powder Zvinoenderana
Identification    
1. UV Max 209, 248, 267, 310nm Qualified
2. IR spectrum Inopindirana neChimiro Qualified
3. Kusarura kweChloride Forward Reaction Qualified
Mvura naKarl Fischer 9.0 ~ 10.5% 9.7%
Residue paIgnition ≤0.10% 0.03%
Masimbi anorema (Pb) ≤10ppm <10ppm
Ondansetron Inoenderana Musanganiswa C ≤0.20% 0.09%
Ondansetron Inoenderana nemubatanidzwa D ≤0.10% 0.04%
Imidazole ≤0.20% 0.02%
2-Methylimidazole ≤0.20% 0.02%
Ondansetron Related Compound A ≤0.20% 0.05%
Zvimwe Zvisingazivikanwe Kusachena Kumwechete ≤0.10% 0.07%
Zvose Zvisina Kuchena ≤0.50% 0.29%
Residual Solvent    
Ethanol ≤5000ppm 240ppm
Assay 98.0 ~ 102.0% (Yakaverengerwa pane anhydrous base) 99.81%
Mhedziso Chigadzirwa chacho chakaedzwa uye chinoenderana nezvinodiwa

Pakeji/Kuchengeta/Shipping:

Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumudziyo wakavharwa zvakasimba.Chengetedza munzvimbo inotonhorera, yakaoma (2 ~ 8 ℃) uye ine mhepo yakanaka yekuchengetera kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.

Zvakanakira:

Yakakwana Capacity: Inokwana zvivakwa uye matekiniki

Professional Service: Imwe inomira kutenga sevhisi

OEM Package: Tsika pasuru uye label iripo

Fast Delivery: Kana iri mukati me stock, mazuva matatu ekutumira anovimbiswa

Yakagadzika Supply: Chengetedza zvine musoro stock

Tsigiro yehunyanzvi: Tekinoroji mhinduro iripo

Tsika Synthesis Service: Kubva pamagiramu kusvika makirogiramu

Hunhu Hwepamusoro: Yakagadzira yakakwana yemhando yekusimbisa system

FAQ:

Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.

Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.

Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.

HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.

Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.

Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.

MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.

Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.

Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.

Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.

Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.

Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.

103639-04-9 - Njodzi uye Kuchengeteka:

Risk Codes
R25 - Muchetura kana ukamedzwa
R36/37/38 - Kushungurudza maziso, kufema system uye ganda.
Tsanangudzo Yekuchengetedza
S45 - Kana pakaitika tsaona kana ukanzwa usinganzwe zvakanaka, tsvaga zano rekurapa nekukasira (ratidza chinyorwa pese pazvinogoneka.)
S37/39 - Pfeka magirovhosi akakodzera uye dziviriro yeziso / kumeso
S26 - Kana wasangana nemaziso, simbura nekukasira nemvura yakawanda uye tsvaga mazano ekurapwa.
UN IDs UN 2811 6.1/PG 3
WGK Germany 3
RTECS FE6375500
HS Code 29339900
Kirasi yeNjodzi 6.1(a)
Packing Group II

103639-04-9 - Application:

Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9) inonzi serotonin chaiyo (5-HT3) inopikisa receptor.Antiemetic.Ondansetron Hydrochloride Dihydrate inoshandiswa kudzivirira kusvotwa uye kurutsa zvinogona kukonzerwa nekuvhiyiwa, kenza chemotherapy, kana kurapwa nemwaranzi.The 5-HT3 receptor antagonists muOndansetron ndiyo mishonga yekutanga inoshandiswa kurapa nekudzivirira chemotherapy-induced nausea uye kurutsa uye radiotherapy-induced nausea uye kurutsa, kuburikidza nekuvhara zviito zvemakemikari mumuviri.Kushanda kwacho kuri nani pane metoclopramide asi isinganyanyi kunyaradza pane cyclizine kana droperidol.Zvisinei, ine simba shoma pakurutsa kunokonzerwa nechirwere chekufamba.Inogona kupihwa nemuromo, nejekiseni mumhasuru kana mutsinga.

Ondansetron uye Granisetron, Dolasetron matatu anowanzo shandiswa nekiriniki antiemetics, ondansetron inobudirira serotonin (5-HT3) receptor blocker iyo inogadziriswa uye inosarudza, ye α1, α2, β1, β2-adrenergic receptors uye histamine H1, H2 receptors, ine mhedzisiro shoma, yeH receptors, yepakati uye yeperipheral dopaminergic receptors, haina anopikisa mhedzisiro, inogona kudzvanya chemotherapy uye radiotherapy-induced nausea uye kurutsa.Kuenzaniswa nemetoclopramide, iyo antiemetic effect yakasimba uye haina extrapyramidal reactions.Nekurutsa kunokonzerwa necisplatin, cyclophosphamide, doxorubicin, nezvimwewo inogona kuburitsa nekukurumidza uye yakasimba antiemetic effect.Haikodzeri chete kurapwa kwekusvotwa uye kurutsa kunokonzerwa necytotoxic chemotherapy uye radiation therapy, asiwo kudzivirira uye kurapwa kwekusvotwa uye kurutsa kunokonzerwa nekuvhiya.Ondansetron inoshanda senzvimbo yekufambisa pakati pe visceral afferent nerve inoshandiswa mudumbu remukati uye nzvimbo yekurutsa mukati memutsipa wepelinha, iyo inotungamirira ku diaphragm uye mafambisi emimba.Chemotherapy uye kurapa kwemwaranzi kunogona kukonzera intestinal 5-HT kusunungurwa uye kukonzera vagus nerve stimulation ne5-HT3 receptor, izvo zvinokonzera kurutsa reflex.Ichi chigadzirwa chinovhara iyi reflex kuitika, panguva imwechete inovhara kurutsa kunokonzerwa nepakati chiitiko.Iyo nzira pamusoro pepostoperative kusvotwa uye kurutsa hazvizivikanwe.Ondansetron pamwe chete nedexamethasonecan inogona kuwedzera anti-emetic effect.

103639-04-9 - Zvikonzero:

Izvi zvinokonzera vagal afferent discharge, zvichiita kurutsa.Mukusunga kune 5-HT3 receptors, ondansetron inovhara serotonin kukurudzira, nekudaro kurutsa, mushure mekuita emetogenic stimuli se cisplatin.Musoro wemusoro ndiwo unonyanya kushumwa wakashata wemishonga iyi.

103639-04-9 - Nhoroondo Yekuchengetedza:

Chepfu by intravenous route.Human systemic effects by intravenous route: jaundice.Kana yapiswa kuti iore inoburitsa mhute ine muchetura yeNOx.

103639-04-9 - Veterinary Drugs uye Kurapa:

Inoshandiswa se antiemetic kana mishonga yakajairika isingashande, senge pakupa cisplatin kana zvimwe zvinokonzeresa kurutsa kusingaite.Kushandiswa kwe ondansetron mumakati kune kukakavara uye imwe inotaura kuti haifaniri kushandiswa mumhando iyi.

Kudyidzana kwezvinodhaka Kudyidzana kune njodzi nemimwe mishonga.

103639-04-9 - USP35 Standard:

Ondansetron Hydrochloride ine isiri pasi pe98.0 muzana uye isingapfuuri 102.0 muzana yeC18H19N3O · HCl, yakaverengerwa pane anhydrous basis.
Kurongedza uye kuchengetedza-Chengetedza mumidziyo yakasimba, isingagadzike chiedza.Chengeta pa25, nzendo dzinobvumirwa pakati pe15uye 30.
USP Reference mwero <11>-
USP Ondansetron Hydrochloride RS
USP Ondansetron Related Compound A RS
3 [(Dimethylamino) methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-imwe.
USP Ondansetron Resolution Mixture RS
Ondansetron hydrochloride ine inenge 0.4% w/w yezvose zviri zviviri ondansetron zvine hukama musanganiswa A uye 6,6¢-methylene bis--[(1,2,3,9-tetrahydro-9-methyl-3--[(2-methyl-1H--) imidazol-1-yl)-methyl]-4H-carbazol-4-one)]
USP Ondansetron Inoenderana Necompound C RS
1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-imwe.
USP Ondansetron Inoenderana Necompound D RS
1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-imwe.
Identification-
A: Infrared Absorption <197M>.
B: Dissolve 20 mg mu 2 mL yemvura, wedzera 1 mL ye2 M nitric acid, uye sefa: filtrate inopindura muedzo weChloride <191>.
Mvura, Nzira Ia <921>: pakati pe9.0% ne10.5%.
Residue pakudzima <281>: kwete kupfuura 0.1%.
Muganhu weondansetron inoenderana nekamu D-
Nharembozha-Gadzirira musanganiswa wakanatswa uye wakasvibiswa we0.02 M monobasic potassium phosphate (yakambogadziriswa ne1 M sodium hydroxide kusvika pH ye5.4) uye acetonitrile (80:20).Ita zvigadziriso kana zvichidikanwa (ona System Suitability pasi peChromatography <621>).
Yakajairwa mhinduro-Dyisa huremu hwakayerwa chaizvo hweUSP Ondansetron Inoenderana Musanganiswa D RS muMobile phase, uye dzikisa huwandu, uye nhanho kana zvichidikanwa, neMobile phase kuti uwane mhinduro ine inoziikanwa concentration inosvika 0.4 µg per mL.
Kukodzera kweSystem solution-Dissolve akakodzera huwandu hweUSP Ondansetron Inoenderana Compound D RS uye USP Ondansetron Inoenderana Compound C RS muMobile phase, uye dzikisa huwandu, uye nhanho kana zvichidikanwa, neMobile phase kuti uwane mhinduro ine muunganidzwa we 0.6 µg per mL. uye 1 µg pa mL, zvichiteerana.
Test solution-Shandura inenge 50 mg yeOndansetron Hydrochloride, yakanyatsoyerwa, kune 100-mL volumetric flask, nyunguduka uye dilute neMobile phase kusvika kuvhoriyamu, uye sanganisa.
Chromatographic system (ona Chromatography <621>) -Iyo chromatograph yemvura yakashongedzerwa ne328-nm detector uye 4.6-mm × 25-cm column ine packing L10.Chiyero chekuyerera chinenge 1.5 mL paminiti.Chromatograph the System suitability solution, uye rekodha mhinduro dzepamusoro sekutaurirwa kweMaitiro: nguva dzekuchengetedza dzinenge dzinenge 0.8 kune ondansetron inoenderana nekomboni C uye 1.0 yeondansetron inoenderana nekomboni D;uye kugadziriswa, R, pakati peondansetron inoenderana nekomboni C uye ondansetron ine hukama mukomboni D haisi pasi pe1.5.Chromatograph the Standard solution, uye rekodha mhinduro dzepamusoro sekurairwa kwaProcedure: ikorumu inoshanda yakatemwa kubva kune analyte peak haisi pasi pe400 theoretical plates;uye kutsauswa kwakayerwa kwemajekiseni ekudzokorora hakupfuuri 2.0%.
Maitiro- Baira mavhoriyamu akaenzana (angangoita 20 µL) eStandard solution uye Test solution muchromatograph, rekodha makromatogram, uye mesa mhinduro dzepamusoro-soro.Verengai muzana yeondansetron ine hukama musanganiswa D muchikamu cheOndansetron Hydrochloride inotorwa neformula:
10,000(C/W)(rU / rS)
umo C ndiyo chiyero, mu mg per mL, ye USP Ondansetron Related Compound D RS muStandard solution;W ndiyo huremu, mumg, yeOndansetron Hydrochloride yakatorwa kugadzirira mhinduro yeMuedzo;uye rU uye rS inzvimbo dzepamusoro dzakawanikwa kubva kuMuedzo mhinduro uye iyo Standard mhinduro, zvichiteerana: haipfuure 0.10% inowanikwa.
Chromatographic kuchena-
nzira i-
Resolution solution-Dissolve a quantity of USP Ondansetron Resolution Mixture RS mumethanol, uye dilute quantitatively, uye nhanho kana zvichidiwa, nemethanol kuti uwane mhinduro ine 12.5 mg inozivikanwa pa mL.
Mishonga yakajairwa-Dissolve huremu hwakayerwa nemazvo hweUSP Ondansetron Hydrochloride RS mumethanol, uye sanganisa kuti uwane mhinduro ine huwandu hunozivikanwa hunosvika 0.25 mg per mL.Dilutedly solution iyi nemethanol kuti uwane Magadzirirwo emhinduro, akanyorwa pazasi netsamba, aine zvinotevera zvinoimbwa:

Standard solution Dilution Concentration (µg RS per mL) Percentage (%, yekuenzanisa neye test specimen)
A (1 mu5) 50 0.4
B (1 mu10) 25 0.2
C (1 mu20) 12.5 0.1

Muedzo wemhinduro-Dissolve yakanyatsoyerwa huwandu hweOndansetron Hydrochloride mumethanol kuti uwane mhinduro ine 12.5 mg per mL.Maitiro-Kuparura shandisa 20 µL yeMuedzo mhinduro, 20 µL yega yega Standard mhinduro, uye 20 µL yeResolution mhinduro kune yakatetepa-layer chromatographic ndiro (ona Chromatography621) yakavharwa ne0.25-mm layer yechromatographic silica gel musanganiswa.Gadzira chromatogram mune inonyungudutsa system inosanganisira musanganiswa wechloroform, ethyl acetate, methanol, uye ammonium hydroxide (90:50:40:1) kusvika iyo inonyungudutsa mberi yafamba inosvika zvikamu zvitatu kubva muzvina zvehurefu hwendiro.Bvisa ndiro kubva mukamuri, maka pamberi pezvinonyungudutsa, uye bvumira iyo inonyungudutsa kuti ibude.Ongorora ndiro iri pasi pepfupi-wavelength UV mwenje: kugadzirisa kwakazara kwezvikamu zvitatu zveResolution solution nzvimbo inowanikwa.Enzanisa kusimba kwechero nzvimbo dzechipiri dzakaonekwa muchromatogram yeMuedzo mhinduro neaya enzvimbo huru mumachromatograms eStandard solutions: chero nzvimbo yechipiri kubva kuchromatogram yemubvunzo mhinduro ine kukosha kweRF inoenderana neicho chepamusoro chesekondari. nzvimbo yeResolution solution haina kukura kana kusimba kupfuura nzvimbo huru yakawanikwa kubva kuStandard solution A (0.4%);uye hapana imwe nzvimbo yechipiri kubva kuchromatogram yeMuedzo mhinduro yakakura kana kusimba kupfuura nzvimbo huru yakawanikwa kubva kuStandard solution B (0.2%).

nzira ii-

Nharembozha chikamu uye Chromatographic system-Pfuura sekurairwa muAssay.
Yakajairwa mhinduro-Pfuurira sekunge yakarairwa kune Standard gadziriro muAssay.
Test solution-Shandisa gadziriro yeAssay.
Maitiro-Baya jekiseni mavhoriyamu akaenzana (angangoita gumi µL) eStandard solution neMuedzo mhinduro mukromatograph, rekodha machromatogram, uye kuyera mhinduro dzepamusoro.Verengai muzana yekusachena kwega kwega muchikamu cheOndansetron Hydrochloride inotorwa neformula:
50,000(C/W)(1/F)(ri / rS)
umo C ndiyo chiyero, mu mg per mL, ye USP Ondansetron Hydrochloride RS muStandard solution;W ndiyo huremu, mumg, yeOndansetron Hydrochloride yakatorwa kugadzirira mhinduro yeMuedzo;F ndiyo inopindirana yemhinduro yekusachena sezvakatsanangurwa mutafura inofambidzana;ri ndiyo nzvimbo yepamusoro yekusachena kwega kwega muMubvunzo mhinduro;uye rS ndiyo nzvimbo yepamusoro ye ondansetron inowanikwa kubva kuStandard solution: inosangana nezvinodiwa zvakapihwa mutafura inoperekedza.

Zita reCompound Relative Retention Time Hama
Mhinduro
Factor
Muganho (%)
Ondansetron inoenderana nechikamu C anenge 0.32 1.2 0.2
Ondansetron inoenderana nemubatanidzwa D* anenge 0.34 - 0.1
Imidazole inenge 0.49 0.3 0.2
2-methylimidazole anenge 0.54 0.4 0.2
Ondansetron 1.0 - -
Ondansetron inoenderana nemubatanidzwa A anenge 1.10 0.8 0.2
Unknown - 1.0 0.1
Total - - 0.5
* Yakaverengerwa muyedzo yeLimit yeondansetron inoenderana nekomboni D.
Kuongorora-

Nharembozha nhanho-Gadzirira musanganiswa wakanatswa uye wakasvibiswa we0.02 M monobasic sodium phosphate (yakambogadziriswa ne1 M sodium hydroxide kusvika pH ye5.4) uye acetonitrile (50:50).Ita zvigadziriso kana zvichidikanwa (ona System Suitability pasi peChromatography <621>).
Kugadzirira kwakajairwa-Bvisa huremu hwakayerwa nemazvo eUSP Ondansetron Hydrochloride RS muMobile phase, uye dilute zvine huwandu, uye nhanho kana zvichidikanwa, neMobile phase kuti uwane mhinduro ine inoziikanwa concentration inosvika 90 µg per mL.
Kukodzera kweSistimu mhinduro-Dyisa huwandu hwakakodzera hweUSP Ondansetron Hydrochloride RS uye USP Ondansetron Related Compound A RS muMobile phase, uye dzikisa huwandu, uye nhanho kana zvichidikanwa, neMobile phase kuti uwane mhinduro ine inosvika makumi mapfumbamwe µg pa mL uye 20 µg pa mL. , zvichiteerana.
Kugadzirira kweAssay-Kutamisa nezve 45 mg yeOndansetron Hydrochloride, yakanyatsoyerwa, kune 50-mL volumetric flask, nyunguduka mukati uye dilute neMobile phase kusvika kuvhoriyamu, uye sanganisa.Pipet 5.0 mL yemhinduro iyi mu50-mL volumetric flask, dilue neMobile phase kusvika kuvhoriyamu, uye sanganisa.
Chromatographic system (ona Chromatography <621>) -Iyo chromatograph yemvura inogadzirwa ne 216-nm detector uye 4.6-mm × 25-cm column ine packing L10.Chiyero chekuyerera chinenge 1.5 mL paminiti.Chromatograph the System suitability solution, uye rekodha mhinduro dzepamusoro sekutaurirwa kweProcedure: nguva dzekuchengetedza dzinenge 1.0 ye ondansetron uye 1.1 yeondansetron inoenderana nekomboni A;uye kugadziriswa, R, pakati peondansetron ine hukama nekomboni A neondansetron haisi pasi pe1.5.Chromatograph the Standard gadziriro, uye rekodha mhinduro dzepamusoro sekurairwa kweMaitiro: iyo tailing factor haina kupfuura 2.0;uye kutsauswa kwakajairwa kwemajekiseni ekudzokorora hakupfuuri 1.5%.
Maitiro-Kuparura jekiseni mavhoriyamu akaenzana (angangoita 10 µL) eGwaro gadziriro uye gadziriro yeAssay muchromatograph, rekodha machromatogram, uye kuyera mhinduro dzepamusoro-soro.Verenga huwandu, mu mg, hweC18H19N3O·HCl muchikamu cheOndansetron Hydrochloride chakatorwa neformula:
500C(rU / rS)
umo C ndiyo chiyero, mu mg per mL, ye USP Ondansetron Hydrochloride RS muStandard gadziriro;uye rU uye rS inzvimbo dzepamusoro dzakawanikwa kubva mukugadzirira kweAssay uye gadziriro yeStandard, zvichiteerana.

103639-04-9 - Nzira yekugadzira:

Nzira 1: Mushure mekuita kwe2-Bromoaniline uye1,3-Cyclohexanedione, tetrahydrocarbazole derivative inoumbwa, uye chidimbu (III) chinowanikwa nekuita ne dimethylamine uye diformaldehyde, uye kuunza dimethylaminomethyl panzvimbo ye2.3.80G yekomboni (III) yakabatwa nemethyl iodide kuti ipe 5.72g yemukomboni (IV) nekugadzirisa mativi emaketani emamino boka panguva yekuunza boka remethyl panzvimbo 9. 2.0g yemukomboni (IV) uye 2-methyl-1h. -imidazole yakabatwa mu dimethylformamide nekukurudzira pa95 ℃.Kuti uwane 0.60G yeOndansetron.

Method 2: Kuita kwe cyclohexanone uye phenylhydrazine yakapa tetrahydrocarbazole mu 85% goho.Dissolve mu tetrahydrofuran nemvura, wedzera 2,3 Dropwise pa 0 °c munitrogen, Mushonga we5, 6-tetrachloro-1,4-benzoquinone mutetrahydrofuran wakamutswa kuti upe chigadzirwa che oxidation (II) mu 67.4% goho.Compound (II), ethanol, concentrated hydrochloric acid, paraformaldehyde uye dimethylamine hydrochloride zvakadzokororwa pamwechete.Mushure mekurapwa, chigadzirwa (V) chakawanikwa nekuwedzera concentrated hydrochloric acid kune acetone uye ichikurudzira pa50 ℃.Mu 71.7% goho.Compound (V) uye 2-methylimidazole yakaitwa mumvura pa110 ℃.Kuti uwane komputa (VI) mu70.9% goho.Compound (VI), methyl iodide uye potassium carbonate zvakamutswa pakamuri yekupisa kusvika iyo yakasimba yanyangarika.Yakadururwa mumvura, yakavhenganiswa, yakasvibiswa, yakashambidzwa nemvura, uye yakagadziridzwa kubva kune methanol kuti iwane ondansetron mu 57.2% goho.Dissolve iyo musanganiswa weacetone nemvura, Nekuwedzera concentrated hydrochloric acid kune maitiro, ondansetron hydrochloride dihydrate yakawanikwa negoho re92.6%.

Method 3: musanganiswa (II), potassium carbonate, acetone uye dimethyl sulfate zvakamutswa pakupisa kwekamuri.Compound (VII) yakawanikwa mugoho re91%.Compound (VII) yakanyungudutswa mu ethanol uye musanganiswa weparaformaldehyde yevanhu uye dimethylamine hydrochloride yakawedzerwa muzvikamu pasi pe reflux.Refluxing.Mushure mekurapwa, komputa (VIII) yakawanikwa mu67% goho.(Viii) yakanyungudutswa muanhydrous ethanol, hydrogen chloride gasi, hydrochloride yayo.Iyo hydrochloride yakawedzerwa kumvura uye 2 yakawedzerwa pa50 ℃.Methylimidazole, refluxing ondansetron, inobereka 70%.Yakanga yakanyungudutswa mu isopropanol, mvura uye yakanyungudutswa hydrochloric acid, uye yakasimudzwa pamhepo tembiricha kuti iwane ondansetron hydrochloride dihydrate mugoho re90.5%.

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