Polymyxin B Sulfate CAS 1405-20-5 Assay Microbiological ≥6500 IU/mg Factory
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri uye mutengesi wePolymyxin B Sulfate (CAS: 1405-20-5) ine mhando yepamusoro.Isu tinogona kupa COA, kuendesa pasi rese, zvidiki uye huwandu hwakawanda huripo.Kana iwe uchifarira Polymyxin B Sulfate,Please contact: alvin@ruifuchem.com
| Chemical Name | Polymyxin B sulfate |
| Mashoko anoreva zvakafanana | Polymyxin B Sulfate Munyu;Aerosporin;Mastimyxin;PXNS;PMB;Poly-RX |
| Stock Status | MuStock, Kukwanisa Kugadzira Matani gumi pagore |
| Nhamba yeCAS | 1405-20-5 |
| Molecular Formula | C55H96N16O13·2H2SO4 |
| Molecular Weight | 1301.56 |
| Melting Point | 217.0~220.0℃(Zvita.) |
| Sensitive | Hygroscopic.Inonzwa Chiedza uye Kupisa |
| Mvura Solubility | Soluble mumvura, 50 mg/mL.Zvishoma Soluble muEthanol |
| COA & MSDS | Available |
| Muenzaniso | Available |
| Brand | Ruifu Chemical |
| Items | Zvinotsanangurwa | Results |
| Chitarisiko | Ichena kana Kupotsa Ne Crystalline Powder | Conforms |
| Identification A. Nguva dzekuchengeta dzepamusoro-soro kubva mumushonga wemuenzaniso dzinoenderana nedziya dzemushonga wenguva dzose, sezvakawanikwa mukuedzwa kwekuumbwa kwePolymyxins. | Conforms | |
| PH (2%) | 5.0~7.0 | 5.7 |
| PH (0.5%) | 5.0~7.5 | 5.5 |
| Sulfated Ash | ≤0.75% |
|
| Kutenderera kwakananga [α]20/D | -78.0°~-90.0°(C=2, H2O) (Calcd. paAnh. Substance) | -85.0° |
| Sulfate | 15.5 ~ 17.5% | 16.65% |
| Kurasika paKuomesa | ≤6.00% | 3.0% |
| Residue paIgnition | ≤0.10% | 0.02% |
| Heavy Metals | ≤20ppm | ≤20ppm |
| Phenylalanine | 9.0 ~ 12.0% | 9.8% |
| Total Viabel Aerobic Count | ≤10cfu/g | ≤10cfu/g |
| Zvinhu zvinoenderana, HPLC |
|
|
| Kusachena Kwemunhu | ≤3.0% | 2.723% |
| Zvose Zvisina Kuchena | ≤17.0% | 16.223% |
| Assay HPLC (ODB) | Huwandu hwePolymyxins B1,B2,B3 uye B1-1: ≥80.0% | 86.6% |
| Polymyxin B3: ≤ 6.0% | 3.8% | |
| Polymyxin B1-1: ≤15.0% | 8.5% | |
| Assay, Microbiological (sezvazviri) | ≥6500lU/mg | 8255IU/mg |
| Particle Size | ≥99.0% ≤30um nevol | Conforms |
| ≥90.0% ≤25um nevol | ||
| ≥75.0%≤20um nevol | ||
| ≥35.0%≤10um nevol | ||
| Mhedziso | Chigadzirwa chinoenderana neUSP42 |
|
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chiedza chinonzwa.Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.Hazvienderani neakasimba oxidizing agents.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Hazard Symbols Xn - Zvinokuvadza
Risk Codes 22 - Zvinokuvadza kana ikamedzwa
Tsanangudzo Yekuchengetedza S22 - Usafeme guruva.
S24/25 - Dzivisa kusangana neganda nemeso.
UN IDs 3249
WGK Germany 3
RTECS TR1150000
FLUKA BRAND F CODES 3-8-10
HS Code 2941909099
Chikamu cheNjodzi 6.1(b)
Kurongedza Boka III
Polymyxin iboka remapolypeptide antibiotics anogadzirwa neBacillus polymyxa (bacilluspolymyxa).Polymyxin B uye E inoshandiswa pakurapa zvinangwa, uye sulfates yavo inowanzoshandiswa.Iyo antibacterial spectrum uye kliniki yekushandiswa kwePolymyxin B Sulfate yakafanana neye polymyxin E. Iine inhibitory kana bactericidal migumisiro pa gram-negative bacilli, yakadai seEscherichia coli, Pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, pertussis uye Shigella.
Polymyxin Sulfate B yakafanana nepolymyxin e, uye ine inhibitory kana bactericidal mhedzisiro pa gram-negative bacilli, senge e.coli, pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, bacilli pertussis uye dysentery bacilli.Inonyanya kushandiswa paronda, urinary turakiti, ziso, nzeve, trachea uye zvimwe zvikamu zvehutachiona hunokonzerwa nePseudomonas aeruginosa nedzimwe Pseudomonas.Inogonawo kushandiswa sepsis uye peritonitis.Uye zvirwere zvakakomba zvinokonzerwa neaminoglycosides, yechitatu-chizvarwa cephalosporin-resistant mabhakitiriya, Pseudomonas aeruginosa kana mamwe mabhakitiriya anonzwa, akadai sebacteremia, endocarditis, pneumonia, post-burn infection, nezvimwewo.
1. Intravenous Drip: vanhu vakuru nevana vane hutano hwemazuva ose 1.5 ~ 2.5mg pa kilogram yehuremu hwemuviri (kazhinji kwete kupfuura 2.5mg pa kilogram yehuremu hwemuviri) kwezuva 1, rakakamurwa kuva 2 nguva, kudonha kamwe chete maawa gumi nemaviri.Yese 50mg yechigadzirwa ichi inonatswa ne500ml ye5% glucose solution yobva yadonha.Vacheche vane hutano hwemazuva ose vanogona kushivirira 4mg pa kilogram yehuremu hwemuviri kwezuva rimwe.2. Intramuscular injection: vanhu vakuru nevana: 2.5 ~ 3mg pa kilogram yehuremu hwemuviri pa1, inopiwa mumabheti, kamwe chete maawa 4 ~ 6.Vacheche vanogona kusvika 4mg pakirogiramu yehuremu hwemuviri pazuva uye vacheche vanogona kusvika 4.5mg pakirogiramu yehuremu hwemuviri.3. Intrathecal injection (yePseudomonas aeruginosa meningitis): 5mg pa millilita yemishonga yemvura yakagadzirwa nejekiseni re sodium chloride.Vakuru nevana vanopfuura makore maviri, 5mg zuva nezuva, mushure memazuva 3-4 ekushandiswa, shandura kune kamwe chete zuva rimwe nerimwe, kanenge mavhiki maviri, kusvikira cerebrospinal fluid tsika isina kunaka, uye zvinyorwa zveshuga zvakajairika.Kune vana vari pasi pemakore maviri, shandisa 2mg kamwe pazuva kwemazuva 3-4 akatevedzana (kana 2.5mg kamwe chete zuva rimwe nerimwe), uye ipapo shandisa 2.5mg kamwe chete zuva rimwe nerimwe kusvikira muedzo wakajairika.4. Kusanganiswa kwemadonhwe eziso ndeye 1 ~ 2.5mg per ml.
Dzivisa kusanganiswa nemishonga inokuvadza itsvo, skeletal muscle relaxants, aminoglycoside antibiotics, anesthetics nemigumisiro yekusununguka kwemhasuru (yakadai seenflurane), nezvimwewo, uye quinine, magnesium, nezvimwewo haigoni kushandiswa intravenously panguva imwe chete.Polymyxin B sulfate inosanganiswa ne sulfonamides, rifampicin, semi-synthetic penicillin, zvichingodaro, pakurapa utachiona hwakanyanya husingaurayiwi ne gram-negative bacteria, uye mhedzisiro yacho iri nani pane yekushandiswa kamwe chete.
1, Vakadzi vane pamuviri uye vanoyamwisa, vana, uye varwere vane kusakwana kwerenal kwakanyanya.2. Ichi chigadzirwa chine muchetura zvakanyanya uye chine hurombo husina kunaka hwekurapa pahurwere hwakadzika hwematishu.Haisiyo yekutanga sarudzo kune chero hutachiona.3. Jekiseni remutsinga rinogona kukonzera kuora mwoyo kwekufema, uko kusingawanzoshandiswa.Inenge hafu yedosi yezuva nezuva inoda kudonhedza mutsinga, kwete kukurumidza bolus kamwechete, kuitira kudzivirira yakakura neuromuscular block.4. Hazvifanirwe kusanganiswa nemamwe madhiragi ane nephrotoxicity kana neuromuscular blockade kudzivirira njodzi.
Biochemical research.Polymyxin B is anti-gram-negative bacilli polypeptide antibiotic, inogona kushandura chimiro chemembrane kuti iburitse mamorekuru madiki uye kutadzisa kukura kwe gram-negative bacteria.Iine bactericidal effect paEscherichia coli.Lipid A zvimedu zvakasungwa kune bhakitiriya lipopolysaccharides.Madiki ma pores anokonzerwa nekunze kweganda cell membrane.Maitiro echiito: inosunga uye inovhiringidza kupera kweiyo cytoplasmic membrane.Antibacterial spectrum: Gram-negative mabhakitiriya.
Polymyxin B, Sulfate.
Polymyxin B Sulfate [1405-20-5].
» Polymyxin B Sulfate ndiyo sulfate munyu werudzi rwepolymyxin, chinhu chinogadzirwa nekukura kweBacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae), kana musanganiswa wemunyu miviri kana kupfuura.Iine potency isingasviki 6000 Polymyxin B Units pamg, inoverengwa pane yakaomeswa.
Kurongedza uye kuchengetedza-Chengetedza mumidziyo yakasimba, isingagadzike chiedza.
Kunyora-Iko kwakaputirwa nokuda kwemishonga inosanganiswa, iyo label inotaura nhamba yePolymyxin B Units mumudziyo uye pamilligram, iyo haina kuitirwa kushandiswa kwekugadzira, kuti haina kubereka, uye kuti simba rayo harigoni kuvimbiswa kwenguva yakareba kupfuura 60. mazuva mushure mekuvhurwa.Iko kunoitirwa kushandiswa mukugadzira mafomu ekubaya jekiseni kana mamwe asina kucheneswa dosage, iyo label inotaura kuti haina mbereko kana kuti inofanirwa kuenderera mberi nekugadziriswa panguva yekugadzirwa kwejekiseni kana mamwe mafomu ekuyeresa.
USP Reference mwero <11>-
USP Polymyxin B Sulfate RS
Identification-
A: Liquid Chromatographic Identification Test-
Nharembozha-Gadzirira musanganiswa we0.1 M tribasic sodium phosphate uye acetonitrile (77:23), uye gadzirisa nephosphoric acid kusvika pH ye3.0.Ita zvigadziriso kana zvichidikanwa (ona System Suitability pasi peChromatography <621>.
Yakajairwa mhinduro-Gadzirira mhinduro yeUSP Polymyxin B Sulfate RS muMobile phase ine kuungana kunosvika 3.5 mg pa mL.Chengetedza mhinduro iyi kubva kuchiedza.
Muedzo mhinduro-Gadzirira mhinduro yePolymyxin B Sulfate muMobile phase ine concentration inosvika 3.5 mg per mL.Chengetedza mhinduro iyi kubva kuchiedza.
Chromatographic system (ona Chromatography <621>) -Iyo chromatograph yemvura inogadzirwa ne 212-nm detector uye 4.6-mm × 25-cm column ine 5-µm packing L1.Chiyero chekuyerera chinenge 1 mL paminiti.
Maitiro-Kuparura jekiseni akaenzana mavhoriyamu (angangoita gumi µL) eiyo Standard solution uye Test mhinduro muchromatograph, uye rekodha machromatogram.Chromatogram yakawanikwa kubva kuMuedzo mhinduro inoenderana nemhando neiyo yakawanikwa kubva kuStandard solution, ichiratidza nhongonya huru inoenderana nepolymyxin B1 uye inokwira pane imwe nguva yekuchengeta ingangoita 0.5 (polymyxin B2) uye 0.6 (polymyxin B3).
B: Dissolve 2 mg mu 5 mL yemvura, wedzera 5 mL ye 2.5 N sodium hydroxide, sanganisa, uye wedzera madonhwe mashanu ecupric sulfate solution (1 mu100), uchizununguka mushure mekuwedzerwa kwedonhwe rega rega: ruvara rutsvuku rweviolet runogadzirwa. .
C: Mhinduro (1 mu20) inosangana nezvinodiwa zvekuedzwa kweSulfate <191>.
pH <791>: pakati pe5.0 ne7.5, mune mhinduro ine 5 mg per mL.
Kurasikirwa pakuomeswa <731> -Dry nezve 100 mg, yakanyatsoyerwa, mubhodhoro re capillary-stoppered mu vacuum pa 60 ℃ kwemaawa matatu: inorasikirwa kwete kupfuura 7.0% yehuremu hwayo.
Zviri mukati me phenylalanine-Shandura inenge 0.375 g yePolymyxin B Sulfate, yakanyatsoyerwa, kusvika ku100-mL volumetric flask, nyunguduka uye inyura ne 0.1 N hydrochloric acid kusvika kuhuwandu, uye sanganisa.Kuyera kunyura kwemhinduro iyi pahukuru hunosvika 264 nm (A264), 258 nm (A258), uye 252 nm (A252), uye kunyura pa280 nm (A280) uye 300 nm (A300).Verengai chikamu che phenylalanine muchikamu chePolymyxin B Sulfate yakatorwa neformula:
(9.4787/W)(A258 – 0.5A252 + 0.5A264 – 1.84A280 + 0.8A300)
umo W inorema, mu g, yePolymyxin B Sulfate yakatorwa: ine pakati pe9% ne12% ye phenylalanine, inoverengwa pane yakaomeswa.
Zvimwe zvinodiwa- Kana zvemishonga inosanganiswa, inosangana nezvinodiwa zveResidue pakubatidza pasi pePolymyxin B yeJekiseni.Iko iyo label inotaura kuti Polymyxin B Sulfate haina mbereko, inosangana nezvinodiwa zveSterlity Tests <71> uye, painoitirwa mafomu ekubaya jekiseni, yePyrogen iri pasi pePolymyxin B yeJekiseni.Ipo iyo label inotaura kuti Polymyxin B Sulfate inofanirwa kuenderera mberi nekugadziriswa panguva yekugadzirwa kweanobayiwa dosage mafomu, inosangana nezvinodiwa zvePyrogen pasi pePolymyxin B yeJekiseni.
Assay-Rambai nePolymyxin B Sulfate sezvinorayirwa pasi peAntibiotics-Microbial Assays <81>.
