(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem uye Darifenacin hydrobromide Pakati
Manufacturer Supply;Kuchena Kwepamusoro uye Mutengo Wemakwikwi
Shanghai Ruifu Chemical Co., Ltd. Commercial Supply Chiral Compounds:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S)-3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Pakati pePanipenem (CAS 87726-17-8) uye Darifenacin hydrobromide (CAS 133099-07-7)
| Chemical Name | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Mashoko anoreva zvakafanana | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Nhamba yeCAS | 104706-47-0 |
| Nhamba yeCAT | RF-CC102 |
| Kuchena / Analysis Method | ≥98.0% (GC) |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C4H10ClNO |
| Molecular Weight | 123.58 |
| Melting Point | 107.0 ~ 111.0 °C |
| Solubility mumvura | Kuda Kujeka |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Off-White kusvika Pale Brown Crystalline Powder |
| Kuchena / Analysis Method | ≥99.7% (GC) |
| Chiral Purity | ≥99.7% ee |
| Residue paIgnition | ≤0.50% |
| Chaicho Kutenderera [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Chero Kusachena Kwemunhu | ≤0.20% |
| Zvose zvisina kuchena | ≤0.30% |
| Test Standard | Enterprise Standard |
| Usage | Pharmaceutical Intermediates;Chiral Compounds |
Analysis Method
Equiupment: GC chiridzwa (Shimadzu GC-2010)
Koramu: DB-17 Agilent 30mX0.53mmX1.0μm
Yekutanga tembiricha yeovheni: 80 ℃
Nguva yekutanga 2.0min
Rate 15 ℃/min
Yekupedzisira tembiricha muovheni: 250 ℃
Nguva yekupedzisira 20min
Mutakuri gasi Nitrogen
Mode Constant kuyerera
Kuyerera 5.0mL/min
Kupatsanura reshiyo 10:1
Injector tembiricha: 250 ℃
Detector tembiricha: 300 ℃
Jekiseni vhoriyamu 1.0μL
Chengetedzo dzinofanirwa kutorwa pamberi pekuongorora:
1. Condition column pa 240℃ kwemaminetsi mashoma makumi matatu.
2. Geza jekiseni uye chenesa jekiseni liner zvakanaka kuti ubvise zvakasvibiswa zvekuongorora kwekare.
3. Geza, omesa uye uzadze diluent mumabhotoro ekugezesa sirinji.
Diluent kugadzirira:
Gadzirira 2% w / v sodium hydroxide solution mumvura.
Kugadzirira kwakajairwa:
Were nezve 100mg ye (R) -3-hydroxyprrolidine hydrochloride standard mubhodhoro, wedzera 1mL ye diluent uye nyungudika.
Kugadzirira bvunzo:
Weresa angangoita 100mg yebvunzo sampuro mubhodhoro, wedzera 1mL ye diluent uye nyungudutsa.Gadzirira mune duplicate.
Maitiro:
Jekiseni isina chinhu (diluent), gadziriro yakajairwa uye kugadzirira bvunzo uchishandisa pamusoro peGC mamiriro.Rega nhongonya nekuda kwekushaikwa.Nguva yekuchengetedza yepamusoro nekuda kwe (R) -3-hydroxyprrolidine inenge 5.0min.
Cherechedza:
Taura mhinduro seavhareji
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri uye mutengesi we (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) ine mhando yepamusoro, inoshandiswa zvakanyanya muorganic synthesis, synthesis yemishonga yepakati. uye Active Pharmaceutical Ingredient (API) synthesis.
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) iri pakati kazhinji mukugadzirwa kwePanipenem (CAS 87726-17-8) uye Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-) -3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) inonzi chiral hydroxy derivative yepyrrlodine inoshandiswa mukugadzirira chiral niologically active compounds dzakadai semuscarinic receptor antagonists uye antimicrobial agents.
Nzira yeSynthesis ye (R) -3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile yakaitwa ne trimethyl chlorosilane mu dichloromethane solvent kuti iwane (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine yakazove hydrogenated paPd / C catalyst. (R) -3-trimethylsiloxyepyrrolidine yakawanikwa ne sodium hydroxide ring closing treatment.Pakupedzisira, iyo (R) -3-hydroxypyrrolidine hydrochloride chigadzirwa chakawanikwa ne concentrated hydrochloric acid treatment uye trimethylsilyl boka rekudzivirira rakabviswa.
